Richard Locksley, MD

Sandler Distinguished Prof
Medicine
+1 415 476-1559

Dr. Locksley is the Director of the Sandler Asthma Basic Research Center (SABRE) and a Howard Hughes Medical Institute Investigator. He is a Professor in the Departments of Medicine and Microbiology & Immunology. He received his undergraduate degree in biochemistry from Harvard and his M.D. from the University of Rochester. After completing his residency at UCSF, he trained in infectious diseases at the University of Washington. Prior to his position as director of the SABRE Center, Dr. Locksley served 18 years as the Chief of the Division of Infectious Diseases at UCSF Medical Center. Dr. Locksley is a fellow of the American Academy of Arts and Sciences and member of the National Academy of Sciences.

Dr. Locksley's laboratory addresses the immune cells and tissue responses that occur during allergic, or type 2, immunity. This includes the processes by which naïve helper T cells differentiate to become allergy-supporting Th2 cells, but also the interactions of these cells with eosinophils, basophils, mast cells and alternatively activated macrophages that mediate activities in peripheral tissues. The laboratory increasingly focuses on innate immunity, particularly since the discovery of Group 2 innate lymphoid cells, or ILC2s, which are prominently involved in allergy. Importantly, the discovery of ILC2s initiated efforts to uncover the ‘ground state’ of allergy by investigating homeostatic pathways involving these cells that might provide insights regarding their primary function in the immune system and in homeostasis.

Dr. Locksley’s laboratory pioneered the use of mice genetically engineered to report cytokines expressed during allergic immune responses. Using these methods, the laboratory participated in the discovery of innate lymphoid type 2 cells, or ILC2s, which represent a previously unknown cell now implicated in allergic immunity. The ability to study the activation and organization of innate ILC2s uncovered a role for cells associated with allergy and asthma, such as eosinophils, in processes involved with basal metabolism and tissue homeostasis. Activation of ILC2s in the small intestine was implicated in alteration of the mucosa to a secretory phenotype characterized by high numbers of goblet cells and tuft cells. The latter, a previously mysterious epithelial cell of unknown function, was shown to be the source of IL-25, a cytokine capable of activating ILC2s and other immune cells associated with allergy and asthma, thus opening up entirely new avenues for discovery.

Publications: 

Colostrum is required for the postnatal ontogeny of small intestine innate lymphoid type 2 cells and successful anti-helminth defences.

Allergy

Rekima A, van den Elsen L, Isnard C, Smyth DJ, Lynn MA, Yee T, Stevens NE, Machado S, Divakara N, Bhasin M, Tjiam MC, Rowel C, Servant F, Burcelin R, Locksley R, Maizels R, Lynn DJ, Egwang T, Verhasselt V

Epithelial zonation along the mouse and human small intestine defines five discrete metabolic domains.

Nature cell biology

Zwick RK, Kasparek P, Palikuqi B, Viragova S, Weichselbaum L, McGinnis CS, McKinley KL, Rathnayake A, Vaka D, Nguyen V, Trentesaux C, Reyes E, Gupta AR, Gartner ZJ, Locksley RM, Gardner JM, Itzkovitz S, Boffelli D, Klein OD

A tuft cell - ILC2 signaling circuit provides therapeutic targets to inhibit gastric metaplasia and tumor development.

Nature communications

O'Keefe RN, Carli ALE, Baloyan D, Chisanga D, Shi W, Afshar-Sterle S, Eissmann MF, Poh AR, Pal B, Seillet C, Locksley RM, Ernst M, Buchert M

Retinoic acid drives intestine-specific adaptation of effector ILC2s originating from distant sites.

The Journal of experimental medicine

Shaikh N, Waterhölter A, Gnirck AC, Becker M, Adamiak V, Henneken L, Wunderlich M, Hartmann W, Linnemann L, Huber TB, Krebs CF, Panzer U, Locksley RM, Wilhelm C, Breloer M, Turner JE

Epithelial zonation along the mouse and human small intestine defines five discrete metabolic domains.

bioRxiv : the preprint server for biology

Zwick RK, Kasparek P, Palikuqi B, Viragova S, Weichselbaum L, McGinnis CS, McKinley KL, Rathnayake A, Vaka D, Nguyen V, Trentesaux C, Reyes E, Gupta AR, Gartner ZJ, Locksley RM, Gardner JM, Itzkovitz S, Boffelli D, Klein OD

Structural characterization of ligand binding and pH-specific enzymatic activity of mouse Acidic Mammalian Chitinase.

bioRxiv : the preprint server for biology

Díaz RE, Ecker AK, Correy GJ, Asthana P, Young ID, Faust B, Thompson MC, Seiple IB, Van Dyken SJ, Locksley RM, Fraser JS

Group 2 innate lymphoid cells constrain type 3/17 lymphocytes in shared stromal niches to restrict liver fibrosis.

bioRxiv : the preprint server for biology

Sbierski-Kind J, Cautivo KM, Wagner JC, Dahlgren MW, Nilsson J, Krasilnikov M, Mroz NM, Lizama CO, Gan AL, Matatia PR, Taruselli MT, Chang AA, Caryotakis S, O'Leary CE, Kotas M, Mattis AN, Peng T, Locksley RM, Molofsky AB

Tuft Cells: Context- and Tissue-Specific Programming for a Conserved Cell Lineage.

Annual review of pathology

Kotas ME, O'Leary CE, Locksley RM

Innate type 2 immunity controls hair follicle commensalism by Demodex mites.

Immunity

Ricardo-Gonzalez RR, Kotas ME, O'Leary CE, Singh K, Damsky W, Liao C, Arouge E, Tenvooren I, Marquez DM, Schroeder AW, Cohen JN, Fassett MS, Lee J, Daniel SG, Bittinger K, D?az RE, Fraser JS, Ali N, Ansel KM, Spitzer MH, Liang HE, Locksley RM

IL-13-programmed airway tuft cells produce PGE2, which promotes CFTR-dependent mucociliary function.

JCI insight

Kotas ME, Moore CM, Gurrola Ii JG, Pletcher SD, Goldberg AN, Alvarez R, Yamato S, Bratcher PE, Shaughnessy CA, Zeitlin PL, Zhang IH, Li Y, Montgomery MT, Lee K, Cope EK, Locksley RM, Seibold MA, Gordon ED

Bile acid-sensitive tuft cells regulate biliary neutrophil influx.

Science immunology

O'Leary CE, Sbierski-Kind J, Kotas ME, Wagner JC, Liang HE, Schroeder AW, de Tenorio JC, von Moltke J, Ricardo-Gonzalez RR, Eckalbar WL, Molofsky AB, Schneider C, Locksley RM

ILC2s - development, divergence, dispersal.

Current opinion in immunology

Ricardo-Gonzalez RR, Molofsky AB, Locksley RM

Interferon gamma constrains type 2 lymphocyte niche boundaries during mixed inflammation.

Immunity

Cautivo KM, Matatia PR, Lizama CO, Mroz NM, Dahlgren MW, Yu X, Sbierski-Kind J, Taruselli MT, Brooks JF, Wade-Vallance A, Caryotakis SE, Chang AA, Liang HE, Zikherman J, Locksley RM, Molofsky AB

Lymph node-resident dendritic cells drive TH2 cell development involving MARCH1.

Science immunology

Castellanos CA, Ren X, Gonzalez SL, Li HK, Schroeder AW, Liang HE, Laidlaw BJ, Hu D, Mak ACY, Eng C, Rodríguez-Santana JR, LeNoir M, Yan Q, Celedón JC, Burchard EG, Zamvil SS, Ishido S, Locksley RM, Cyster JG, Huang X, Shin JS

Alveolar macrophages rely on GM-CSF from alveolar epithelial type 2 cells before and after birth.

The Journal of experimental medicine

Gschwend J, Sherman SPM, Ridder F, Feng X, Liang HE, Locksley RM, Becher B, Schneider C

CISH constrains the tuft-ILC2 circuit to set epithelial and immune tone.

Mucosal immunology

Kotas ME, Mroz NM, Koga S, Liang HE, Schroeder AW, Ricardo-Gonzalez RR, Schneider C, Locksley RM

Corrections.

Current protocols

O'Leary CE, Feng X, Cortez VS, Locksley RM, Schneider C

A role for IL-33-activated ILC2s in eosinophilic vasculitis.

JCI insight

Kotas ME, Dion J, Van Dyken S, Ricardo-Gonzalez RR, Danel CJ, Taillé C, Mouthon L, Locksley RM, Terrier B

A stromal progenitor and ILC2 niche promotes muscle eosinophilia and fibrosis-associated gene expression.

Cell reports

Kastenschmidt JM, Coulis G, Farahat PK, Pham P, Rios R, Cristal TT, Mannaa AH, Ayer RE, Yahia R, Deshpande AA, Hughes BS, Savage AK, Giesige CR, Harper SQ, Locksley RM, Mozaffar T, Villalta SA

Interrogating the Small Intestine Tuft Cell-ILC2 Circuit Using In Vivo Manipulations.

Current protocols

O'Leary CE, Feng X, Cortez VS, Locksley RM, Schneider C

Skin-resident innate lymphoid cells converge on a pathogenic effector state.

Nature

Bielecki P, Riesenfeld SJ, Hütter JC, Torlai Triglia E, Kowalczyk MS, Ricardo-Gonzalez RR, Lian M, Amezcua Vesely MC, Kroehling L, Xu H, Slyper M, Muus C, Ludwig LS, Christian E, Tao L, Kedaigle AJ, Steach HR, York AG, Skadow MH, Yaghoubi P, Dionne D, Jarret A, McGee HM, Porter CBM, Licona-Limón P, Bailis W, Jackson R, Gagliani N, Gasteiger G, Locksley RM, Regev A, Flavell RA

In Situ Maturation and Tissue Adaptation of Type 2 Innate Lymphoid Cell Progenitors.

Immunity

Zeis P, Lian M, Fan X, Herman JS, Hernandez DC, Gentek R, Elias S, Symowski C, Knöpper K, Peltokangas N, Friedrich C, Doucet-Ladeveze R, Kabat AM, Locksley RM, Voehringer D, Bajenoff M, Rudensky AY, Romagnani C, Grün D, Gasteiger G

Tissue-specific pathways extrude activated ILC2s to disseminate type 2 immunity.

The Journal of experimental medicine

Ricardo-Gonzalez RR, Schneider C, Liao C, Lee J, Liang HE, Locksley RM

Tissue immunity broadcasts near and far.

Nature reviews. Immunology

Molofsky AB, Locksley RM

Differences in the chitinolytic activity of mammalian chitinases on soluble and insoluble substrates.

Protein science : a publication of the Protein Society

Barad BA, Liu L, Diaz RE, Basilio R, Van Dyken SJ, Locksley RM, Fraser JS

Regulation of immune responses by tuft cells.

Nature reviews. Immunology

Schneider C, O'Leary CE, Locksley RM

Making Asthma Crystal Clear.

The New England journal of medicine

Fahy JV, Locksley RM

ILC2s chew the fat.

The Journal of experimental medicine

Ricardo-Gonzalez RR, Locksley RM

Tissue-Resident Group 2 Innate Lymphoid Cells Differentiate by Layered Ontogeny and In Situ Perinatal Priming.

Immunity

Schneider C, Lee J, Koga S, Ricardo-Gonzalez RR, Nussbaum JC, Smith LK, Villeda SA, Liang HE, Locksley RM

Tuft Cells-Systemically Dispersed Sensory Epithelia Integrating Immune and Neural Circuitry.

Annual review of immunology

O'Leary CE, Schneider C, Locksley RM

Publisher Correction: Parasitic helminths induce fetal-like reversion in the intestinal stem cell niche.

Nature

Nusse YM, Savage AK, Marangoni P, Rosendahl-Huber AKM, Landman TA, de Sauvage FJ, Locksley RM, Klein OD

Tissue signals imprint ILC2 identity with anticipatory function.

Nature immunology

Ricardo-Gonzalez RR, Van Dyken SJ, Schneider C, Lee J, Nussbaum JC, Liang HE, Vaka D, Eckalbar WL, Molofsky AB, Erle DJ, Locksley RM

Innate Lymphoid Cells: 10 Years On.

Cell

Vivier E, Artis D, Colonna M, Diefenbach A, Di Santo JP, Eberl G, Koyasu S, Locksley RM, McKenzie ANJ, Mebius RE, Powrie F, Spits H

Thymic tuft cells promote an IL-4-enriched medulla and shape thymocyte development.

Nature

Miller CN, Proekt I, von Moltke J, Wells KL, Rajpurkar AR, Wang H, Rattay K, Khan IS, Metzger TC, Pollack JL, Fries AC, Lwin WW, Wigton EJ, Parent AV, Kyewski B, Erle DJ, Hogquist KA, Steinmetz LM, Locksley RM, Anderson MS

Detection of Succinate by Intestinal Tuft Cells Triggers a Type 2 Innate Immune Circuit.

Immunity

Nadjsombati MS, McGinty JW, Lyons-Cohen MR, Jaffe JB, DiPeso L, Schneider C, Miller CN, Pollack JL, Nagana Gowda GA, Fontana MF, Erle DJ, Anderson MS, Locksley RM, Raftery D, von Moltke J

Chitins and chitinase activity in airway diseases.

The Journal of allergy and clinical immunology

Van Dyken SJ, Locksley RM

Parasitic helminths induce fetal-like reversion in the intestinal stem cell niche.

Nature

Nusse YM, Savage AK, Marangoni P, Rosendahl-Huber AKM, Landman TA, de Sauvage FJ, Locksley RM, Klein OD

Why Innate Lymphoid Cells?

Immunity

Kotas ME, Locksley RM

A Metabolite-Triggered Tuft Cell-ILC2 Circuit Drives Small Intestinal Remodeling.

Cell

Schneider C, O'Leary CE, von Moltke J, Liang HE, Ang QY, Turnbaugh PJ, Radhakrishnan S, Pellizzon M, Ma A, Locksley RM

Pulmonary neuroendocrine cells amplify allergic asthma responses.

Science (New York, N.Y.)

Sui P, Wiesner DL, Xu J, Zhang Y, Lee J, Van Dyken S, Lashua A, Yu C, Klein BS, Locksley RM, Deutsch G, Sun X

Perinatal Licensing of Thermogenesis by IL-33 and ST2.

Cell

Odegaard JI, Lee MW, Sogawa Y, Bertholet AM, Locksley RM, Weinberg DE, Kirichok Y, Deo RC, Chawla A

MicroRNA regulation of type 2 innate lymphoid cell homeostasis and function in allergic inflammation.

The Journal of experimental medicine

Singh PB, Pua HH, Happ HC, Schneider C, von Moltke J, Locksley RM, Baumjohann D, Ansel KM

Turning the light on.

Nature reviews. Immunology

Locksley R

The Development of Steady-State Activation Hubs between Adult LTi ILC3s and Primed Macrophages in Small Intestine.

Journal of immunology (Baltimore, Md. : 1950)

Savage AK, Liang HE, Locksley RM

Recruited Monocytes and Type 2 Immunity Promote Lung Regeneration following Pneumonectomy.

Cell stem cell

Lechner AJ, Driver IH, Lee J, Conroy CM, Nagle A, Locksley RM, Rock JR

Spontaneous Chitin Accumulation in Airways and Age-Related Fibrotic Lung Disease.

Cell

Van Dyken SJ, Liang HE, Naikawadi RP, Woodruff PG, Wolters PJ, Erle DJ, Locksley RM

Leukotrienes provide an NFAT-dependent signal that synergizes with IL-33 to activate ILC2s.

The Journal of experimental medicine

von Moltke J, O'Leary CE, Barrett NA, Kanaoka Y, Austen KF, Locksley RM

Determinants of Divergent Adaptive Immune Responses after Airway Sensitization with Ligands of Toll-Like Receptor 5 or Toll-Like Receptor 9.

PloS one

Lee LM, Ji M, Sinha M, Dong MB, Ren X, Wang Y, Lowell CA, Ghosh S, Locksley RM, DeFranco AL

A tissue checkpoint regulates type 2 immunity.

Nature immunology

Van Dyken SJ, Nussbaum JC, Lee J, Molofsky AB, Liang HE, Pollack JL, Gate RE, Haliburton GE, Ye CJ, Marson A, Erle DJ, Locksley RM

Perinatal Licensing of Thermogenesis by IL-33 and ST2.

Cell

Odegaard JI, Lee MW, Sogawa Y, Bertholet AM, Locksley RM, Weinberg DE, Kirichok Y, Deo RC, Chawla A

Dual epithelial and immune cell function of Dvl1 regulates gut microbiota composition and intestinal homeostasis.

JCI insight

Belinson H, Savage AK, Fadrosh D, Kuo YM, Lin D, Valladares R, Nusse Y, Wynshaw-Boris A, Lynch SV, Locksley RM, Klein OD

Cross-Talk between Epithelial Cells and Type 2 Immune Signaling. The Role of IL-25.

American journal of respiratory and critical care medicine

Gordon ED, Locksley RM, Fahy JV

Group 2 innate lymphoid cells utilize the IRF4-IL-9 module to coordinate epithelial cell maintenance of lung homeostasis.

Mucosal immunology

Mohapatra A, Van Dyken SJ, Schneider C, Nussbaum JC, Liang HE, Locksley RM

Interleukin-33 and Interferon-γ Counter-Regulate Group 2 Innate Lymphoid Cell Activation during Immune Perturbation.

Immunity

Molofsky AB, Van Gool F, Liang HE, Van Dyken SJ, Nussbaum JC, Lee J, Bluestone JA, Locksley RM

Interleukin-33 in Tissue Homeostasis, Injury, and Inflammation.

Immunity

Molofsky AB, Savage AK, Locksley RM

New blood: Creative funding of disease-specific research.

Science translational medicine

Seaman WE, Locksley RM, Welsh MJ

Eosinophil-specific deletion of IκBα in mice reveals a critical role of NF-κB-induced Bcl-xL for inhibition of apoptosis.

Blood

Schwartz C, Willebrand R, Huber S, Rupec RA, Wu D, Locksley R, Voehringer D

IgE-activated basophils regulate eosinophil tissue entry by modulating endothelial function.

The Journal of experimental medicine

Cheng LE, Sullivan BM, Retana LE, Allen CD, Liang HE, Locksley RM

A novel model for IFN-γ-mediated autoinflammatory syndromes.

Journal of immunology (Baltimore, Md. : 1950)

Reinhardt RL, Liang HE, Bao K, Price AE, Mohrs M, Kelly BL, Locksley RM

Activated type 2 innate lymphoid cells regulate beige fat biogenesis.

Cell

Lee MW, Odegaard JI, Mukundan L, Qiu Y, Molofsky AB, Nussbaum JC, Yun K, Locksley RM, Chawla A

Allergic inflammation--innately homeostatic.

Cold Spring Harbor perspectives in biology

Cheng LE, Locksley RM

Interleukin-5-producing group 2 innate lymphoid cells control eosinophilia induced by interleukin-2 therapy.

Blood

Van Gool F, Molofsky AB, Morar MM, Rosenzwajg M, Liang HE, Klatzmann D, Locksley RM, Bluestone JA

I-L-C-2 it: type 2 immunity and group 2 innate lymphoid cells in homeostasis.

Current opinion in immunology

von Moltke J, Locksley RM

Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat.

Cell

Qiu Y, Nguyen KD, Odegaard JI, Cui X, Tian X, Locksley RM, Palmiter RD, Chawla A

Leukotriene B4 amplifies eosinophil accumulation in response to nematodes.

The Journal of experimental medicine

Patnode ML, Bando JK, Krummel MF, Locksley RM, Rosen SD

Eosinophils are recruited in response to chitin exposure and enhance Th2-mediated immune pathology in Aspergillus fumigatus infection.

Infection and immunity

O'Dea EM, Amarsaikhan N, Li H, Downey J, Steele E, Van Dyken SJ, Locksley RM, Templeton SP

Asthma and the flu: a tricky two-step.

Immunology and cell biology

Locksley RM, Fahy JV

Chitin activates parallel immune modules that direct distinct inflammatory responses via innate lymphoid type 2 and γδ T cells.

Immunity

Van Dyken SJ, Mohapatra A, Nussbaum JC, Molofsky AB, Thornton EE, Ziegler SF, McKenzie AN, Krummel MF, Liang HE, Locksley RM

Cutting edge: IL-25 elicits innate lymphoid type 2 and type II NKT cells that regulate obesity in mice.

Journal of immunology (Baltimore, Md. : 1950)

Hams E, Locksley RM, McKenzie AN, Fallon PG

Type 2 innate lymphoid cells control eosinophil homeostasis.

Nature

Nussbaum JC, Van Dyken SJ, von Moltke J, Cheng LE, Mohapatra A, Molofsky AB, Thornton EE, Krummel MF, Chawla A, Liang HE, Locksley RM

Type 2 innate lymphoid cells constitutively express arginase-I in the naive and inflamed lung.

Journal of leukocyte biology

Bando JK, Nussbaum JC, Liang HE, Locksley RM

Traumatic brain injury induces macrophage subsets in the brain.

European journal of immunology

Hsieh CL, Kim CC, Ryba BE, Niemi EC, Bando JK, Locksley RM, Liu J, Nakamura MC, Seaman WE

Eosinophils secrete IL-4 to facilitate liver regeneration.

Proceedings of the National Academy of Sciences of the United States of America

Goh YP, Henderson NC, Heredia JE, Red Eagle A, Odegaard JI, Lehwald N, Nguyen KD, Sheppard D, Mukundan L, Locksley RM, Chawla A

Type 2 innate signals stimulate fibro/adipogenic progenitors to facilitate muscle regeneration.

Cell

Heredia JE, Mukundan L, Chen FM, Mueller AA, Deo RC, Locksley RM, Rando TA, Chawla A

Raggin' on T-bet.

Cell metabolism

Locksley RM

Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages.

The Journal of experimental medicine

Molofsky AB, Nussbaum JC, Liang HE, Van Dyken SJ, Cheng LE, Mohapatra A, Chawla A, Locksley RM

Innate lymphoid cells--a proposal for uniform nomenclature.

Nature reviews. Immunology

Spits H, Artis D, Colonna M, Diefenbach A, Di Santo JP, Eberl G, Koyasu S, Locksley RM, McKenzie AN, Mebius RE, Powrie F, Vivier E

Distinct populations of innate CD8+ T cells revealed in a CXCR3 reporter mouse.

Journal of immunology (Baltimore, Md. : 1950)

Oghumu S, Dong R, Varikuti S, Shawler T, Kampfrath T, Terrazas CA, Lezama-Davila C, Ahmer BM, Whitacre CC, Rajagopalan S, Locksley R, Sharpe AH, Satoskar AR

Perivascular mast cells dynamically probe cutaneous blood vessels to capture immunoglobulin E.

Immunity

Cheng LE, Hartmann K, Roers A, Krummel MF, Locksley RM

Immature murine NKT cells pass through a stage of developmentally programmed innate IL-4 secretion.

Journal of leukocyte biology

Dickgreber N, Farrand KJ, van Panhuys N, Knight DA, McKee SJ, Chong ML, Miranda-Hernandez S, Baxter AG, Locksley RM, Le Gros G, Hermans IF

Marking and quantifying IL-17A-producing cells in vivo.

PloS one

Price AE, Reinhardt RL, Liang HE, Locksley RM

Spatiotemporally separated antigen uptake by alveolar dendritic cells and airway presentation to T cells in the lung.

The Journal of experimental medicine

Thornton EE, Looney MR, Bose O, Sen D, Sheppard D, Locksley R, Huang X, Krummel MF

Infectious (Non)tolerance--frustrated commensalism gone awry?

Cold Spring Harbor perspectives in biology

Nussbaum JC, Locksley RM

Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity.

Nature immunology

Liang HE, Reinhardt RL, Bando JK, Sullivan BM, Ho IC, Locksley RM

Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis.

Nature

Nguyen KD, Qiu Y, Cui X, Goh YP, Mwangi J, David T, Mukundan L, Brombacher F, Locksley RM, Chawla A

Deletion of Syk in neutrophils prevents immune complex arthritis.

Journal of immunology (Baltimore, Md. : 1950)

Elliott ER, Van Ziffle JA, Scapini P, Sullivan BM, Locksley RM, Lowell CA

A protective role for periostin and TGF-β in IgE-mediated allergy and airway hyperresponsiveness.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology

Gordon ED, Sidhu SS, Wang ZE, Woodruff PG, Yuan S, Solon MC, Conway SJ, Huang X, Locksley RM, Fahy JV

The airway epithelium as a regulator of Th2 responses in asthma.

American journal of respiratory and critical care medicine

Fahy JV, Locksley RM

Fungal chitin from asthma-associated home environments induces eosinophilic lung infiltration.

Journal of immunology (Baltimore, Md. : 1950)

Van Dyken SJ, Garcia D, Porter P, Huang X, Quinlan PJ, Blanc PD, Corry DB, Locksley RM

Genetic analysis of basophil function in vivo.

Nature immunology

Sullivan BM, Liang HE, Bando JK, Wu D, Cheng LE, McKerrow JK, Allen CD, Locksley RM

Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis.

Science (New York, N.Y.)

Wu D, Molofsky AB, Liang HE, Ricardo-Gonzalez RR, Jouihan HA, Bando JK, Chawla A, Locksley RM

Accumulation of eosinophils in intestine-draining mesenteric lymph nodes occurs after Trichuris muris infection.

Parasite immunology

Svensson M, Bell L, Little MC, DeSchoolmeester M, Locksley RM, Else KJ

IL-4/STAT6 immune axis regulates peripheral nutrient metabolism and insulin sensitivity.

Proceedings of the National Academy of Sciences of the United States of America

Ricardo-Gonzalez RR, Red Eagle A, Odegaard JI, Jouihan H, Morel CR, Heredia JE, Mukundan L, Wu D, Locksley RM, Chawla A

Control of intestinal Nod2-mediated peptidoglycan recognition by epithelium-associated lymphocytes.

Mucosal immunology

Duerr CU, Salzman NH, Dupont A, Szabo A, Normark BH, Normark S, Locksley RM, Mellroth P, Hornef MW

Lymphocyte development requires S-nitrosoglutathione reductase.

Journal of immunology (Baltimore, Md. : 1950)

Yang Z, Wang ZE, Doulias PT, Wei W, Ischiropoulos H, Locksley RM, Liu L

Murine B cells regulate serum IgE levels in a CD23-dependent manner.

Journal of immunology (Baltimore, Md. : 1950)

Cheng LE, Wang ZE, Locksley RM

Systemically dispersed innate IL-13-expressing cells in type 2 immunity.

Proceedings of the National Academy of Sciences of the United States of America

Price AE, Liang HE, Sullivan BM, Reinhardt RL, Eisley CJ, Erle DJ, Locksley RM

Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor.

Immunity

Mingueneau M, Roncagalli R, Grégoire C, Kissenpfennig A, Miazek A, Archambaud C, Wang Y, Perrin P, Bertosio E, Sansoni A, Richelme S, Locksley RM, Aguado E, Malissen M, Malissen B

Nine lives: plasticity among T helper cell subsets.

The Journal of experimental medicine

Locksley RM

In situ IL-12/23p40 production during mycobacterial infection is sustained by CD11bhigh dendritic cells localized in tissue sites distinct from those harboring bacilli.

Journal of immunology (Baltimore, Md. : 1950)

Rothfuchs AG, Egen JG, Feng CG, Antonelli LR, Bafica A, Winter N, Locksley RM, Sher A

IL-18 and IL-33 elicit Th2 cytokines from basophils via a MyD88- and p38alpha-dependent pathway.

Journal of leukocyte biology

Kroeger KM, Sullivan BM, Locksley RM

Differential enzymatic activity of common haplotypic versions of the human acidic Mammalian chitinase protein.

The Journal of biological chemistry

Seibold MA, Reese TA, Choudhry S, Salam MT, Beckman K, Eng C, Atakilit A, Meade K, Lenoir M, Watson HG, Thyne S, Kumar R, Weiss KB, Grammer LC, Avila P, Schleimer RP, Fahy JV, Rodriguez-Santana J, Rodriguez-Cintron W, Boot RG, Sheppard D, Gilliland FD, Locksley RM, Burchard EG

Cytokine-secreting follicular T cells shape the antibody repertoire.

Nature immunology

Reinhardt RL, Liang HE, Locksley RM

The inflammasome and alum-mediated adjuvanticity.

F1000 biology reports

Kang SJ, Locksley RM

Visualization of IFNbeta production by plasmacytoid versus conventional dendritic cells under specific stimulation conditions in vivo.

Proceedings of the National Academy of Sciences of the United States of America

Scheu S, Dresing P, Locksley RM

Normal development and activation but altered cytokine production of Fyn-deficient CD4+ T cells.

Journal of immunology (Baltimore, Md. : 1950)

Mamchak AA, Sullivan BM, Hou B, Lee LM, Gilden JK, Krummel MF, Locksley RM, DeFranco AL

Yersinia pestis evades TLR4-dependent induction of IL-12(p40)2 by dendritic cells and subsequent cell migration.

Journal of immunology (Baltimore, Md. : 1950)

Robinson RT, Khader SA, Locksley RM, Lien E, Smiley ST, Cooper AM

Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development.

Cell

Cisse B, Caton ML, Lehner M, Maeda T, Scheu S, Locksley R, Holmberg D, Zweier C, den Hollander NS, Kant SG, Holter W, Rauch A, Zhuang Y, Reizis B

Thymic selection determines gammadelta T cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon gamma.

Immunity

Jensen KD, Su X, Shin S, Li L, Youssef S, Yamasaki S, Steinman L, Saito T, Locksley RM, Davis MM, Baumgarth N, Chien YH

Homeostasis and effector function of lymphopenia-induced "memory-like" T cells in constitutively T cell-depleted mice.

Journal of immunology (Baltimore, Md. : 1950)

Voehringer D, Liang HE, Locksley RM

The Roaring Twenties.

Immunity

Locksley RM

Autoimmunity: altered self-N-glycans trigger innate-mediated autoimmunity.

Immunology and cell biology

Van Dyken SJ, Locksley RM

Regulation of homeostatic chemokine expression and cell trafficking during immune responses.

Science (New York, N.Y.)

Mueller SN, Hosiawa-Meagher KA, Konieczny BT, Sullivan BM, Bachmann MF, Locksley RM, Ahmed R, Matloubian M

A costimulation-initiated signaling pathway regulates NFATc1 transcription in T lymphocytes.

Journal of immunology (Baltimore, Md. : 1950)

Nurieva RI, Chuvpilo S, Wieder ED, Elkon KB, Locksley R, Serfling E, Dong C

Chitin induces accumulation in tissue of innate immune cells associated with allergy.

Nature

Reese TA, Liang HE, Tager AM, Luster AD, Van Rooijen N, Voehringer D, Locksley RM

IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge.

Nature immunology

Khader SA, Bell GK, Pearl JE, Fountain JJ, Rangel-Moreno J, Cilley GE, Shen F, Eaton SM, Gaffen SL, Swain SL, Locksley RM, Haynes L, Randall TD, Cooper AM

Nippostrongylus brasiliensis: identification of intelectin-1 and -2 as Stat6-dependent genes expressed in lung and intestine during infection.

Experimental parasitology

Voehringer D, Stanley SA, Cox JS, Completo GC, Lowary TL, Locksley RM

Neutrophil histamine contributes to inflammation in mycoplasma pneumonia.

The Journal of experimental medicine

Xu X, Zhang D, Zhang H, Wolters PJ, Killeen NP, Sullivan BM, Locksley RM, Lowell CA, Caughey GH

Inhibition of T cell activation and autoimmune diabetes using a B cell surface-linked CTLA-4 agonist.

The Journal of clinical investigation

Fife BT, Griffin MD, Abbas AK, Locksley RM, Bluestone JA

Visualization of IL-12/23p40 in vivo reveals immunostimulatory dendritic cell migrants that promote Th1 differentiation.

Journal of immunology (Baltimore, Md. : 1950)

Reinhardt RL, Hong S, Kang SJ, Wang ZE, Locksley RM

LACK-reactive CD4+ T cells require autocrine IL-2 to mediate susceptibility to Leishmania major.

European journal of immunology

Gumy A, Aseffa A, Rachinel N, Breton M, Otten L, Tacchini-Cottier F, Röcken M, Doyen N, Acha-Orbea H, Locksley RM, MacDonald HR, Launois P, Louis J

Type 2 immunity is controlled by IL-4/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system.

The Journal of experimental medicine

Voehringer D, Reese TA, Huang X, Shinkai K, Locksley RM

Activation of the integrated stress response during T helper cell differentiation.

Nature immunology

Scheu S, Stetson DB, Reinhardt RL, Leber JH, Mohrs M, Locksley RM

Replication initiation from a novel origin identified in the Th2 cytokine cluster locus requires a distant conserved noncoding sequence.

Journal of immunology (Baltimore, Md. : 1950)

Hayashida T, Oda M, Ohsawa K, Yamaguchi A, Hosozawa T, Locksley RM, Giacca M, Masai H, Miyatake S

T helper cell effector fates--who, how and where?

Current opinion in immunology

Reinhardt RL, Kang SJ, Liang HE, Locksley RM

Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice.

Nature immunology

Tang Q, Adams JY, Tooley AJ, Bi M, Fife BT, Serra P, Santamaria P, Locksley RM, Krummel MF, Bluestone JA

Cytokine reporter mouse system for screening novel IL12/23 p40-inducing compounds.

Molecules and cells

Im W, Kim H, Yun D, Seo SY, Park SH, Locksley RM, Hong S

A two-step process for cytokine production revealed by IL-4 dual-reporter mice.

Immunity

Mohrs K, Wakil AE, Killeen N, Locksley RM, Mohrs M

Inducible costimulator is required for type 2 antibody isotype switching but not T helper cell type 2 responses in chronic nematode infection.

Proceedings of the National Academy of Sciences of the United States of America

Loke P, Zang X, Hsuan L, Waitz R, Locksley RM, Allen JE, Allison JP

Interleukin-4 can be a key positive regulator of inflammatory arthritis.

Arthritis and rheumatism

Ohmura K, Nguyen LT, Locksley RM, Mathis D, Benoist C

CD200 receptor family members represent novel DAP12-associated activating receptors on basophils and mast cells.

The Journal of biological chemistry

Voehringer D, Rosen DB, Lanier LL, Locksley RM

Innate immune responses in peptidoglycan recognition protein L-deficient mice.

Molecular and cellular biology

Xu M, Wang Z, Locksley RM

Th2 cells: orchestrating barrier immunity.

Advances in immunology

Stetson DB, Voehringer D, Grogan JL, Xu M, Reinhardt RL, Scheu S, Kelly BL, Locksley RM

Basal chromatin modification at the IL-4 gene in helper T cells.

Journal of immunology (Baltimore, Md. : 1950)

Grogan JL, Wang ZE, Stanley S, Harmon B, Loots GG, Rubin EM, Locksley RM

Leishmania major LACK antigen is required for efficient vertebrate parasitization.

The Journal of experimental medicine

Kelly BL, Stetson DB, Locksley RM

Constitutive cytokine mRNAs mark natural killer (NK) and NK T cells poised for rapid effector function.

The Journal of experimental medicine

Stetson DB, Mohrs M, Reinhardt RL, Baron JL, Wang ZE, Gapin L, Kronenberg M, Locksley RM

Mouse V alpha 14i natural killer T cells are resistant to cytokine polarization in vivo.

Proceedings of the National Academy of Sciences of the United States of America

Matsuda JL, Gapin L, Baron JL, Sidobre S, Stetson DB, Mohrs M, Locksley RM, Kronenberg M

Lung CD25 CD4 regulatory T cells suppress type 2 immune responses but not bronchial hyperreactivity.

Journal of immunology (Baltimore, Md. : 1950)

Hadeiba H, Locksley RM

Stat signals release activated naive Th cells from an anergic checkpoint.

Journal of immunology (Baltimore, Md. : 1950)

Mohrs M, Lacy DA, Locksley RM

CTLA-4 regulates the requirement for cytokine-induced signals in T(H)2 lineage commitment.

Nature immunology

Bour-Jordan H, Grogan JL, Tang Q, Auger JA, Locksley RM, Bluestone JA

Helper T cells regulate type-2 innate immunity in vivo.

Nature

Shinkai K, Mohrs M, Locksley RM

Blood lines.

Nature immunology

Locksley RM

Regulation of CD1 function and NK1.1(+) T cell selection and maturation by cathepsin S.

Immunity

Riese RJ, Shi GP, Villadangos J, Stetson D, Driessen C, Lennon-Dumenil AM, Chu CL, Naumov Y, Behar SM, Ploegh H, Locksley R, Chapman HA

Modulation of blood fluke development in the liver by hepatic CD4+ lymphocytes.

Science (New York, N.Y.)

Davies SJ, Grogan JL, Blank RB, Lim KC, Locksley RM, McKerrow JH

Flow cytometric determination of cellular sources and frequencies of key cytokine-producing lymphocytes directed against recombinant LACK and soluble Leishmania antigen in human cutaneous leishmaniasis.

Infection and immunity

Bottrel RL, Dutra WO, Martins FA, Gontijo B, Carvalho E, Barral-Netto M, Barral A, Almeida RP, Mayrink W, Locksley R, Gollob KJ

Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets.

Immunity

Grogan JL, Mohrs M, Harmon B, Lacy DA, Sedat JW, Locksley RM

Flying doctors.

Nature immunology

Locksley RM

Requirements for the maintenance of Th1 immunity in vivo following DNA vaccination: a potential immunoregulatory role for CD8+ T cells.

Journal of immunology (Baltimore, Md. : 1950)

Gurunathan S, Stobie L, Prussin C, Sacks DL, Glaichenhaus N, Iwasaki A, Fowell DJ, Locksley RM, Chang JT, Wu CY, Seder RA

Baseline airway hyperreactivity in A/J mice is not mediated by cells of the adaptive immune system.

Journal of immunology (Baltimore, Md. : 1950)

Hadeiba H, Corry DB, Locksley RM

Faithful expression of the human 5q31 cytokine cluster in transgenic mice.

Journal of immunology (Baltimore, Md. : 1950)

Lacy DA, Wang ZE, Symula DJ, McArthur CJ, Rubin EM, Frazer KA, Locksley RM

In BALB/c mice, IL-4 production during the initial phase of infection with Leishmania major is necessary and sufficient to instruct Th2 cell development resulting in progressive disease.

Journal of immunology (Baltimore, Md. : 1950)

Himmelrich H, Launois P, Maillard I, Biedermann T, Tacchini-Cottier F, Locksley RM, Röcken M, Louis JA

Identification of a coordinate regulator of interleukins 4, 13, and 5 by cross-species sequence comparisons.

Science (New York, N.Y.)

Loots GG, Locksley RM, Blankespoor CM, Wang ZE, Miller W, Rubin EM, Frazer KA

CD1, tuberculosis, and the evolution of major histocompatibility complex molecules.

The Journal of experimental medicine

Shinkai K, Locksley RM

Robust B cell immunity but impaired T cell proliferation in the absence of CD134 (OX40).

Journal of immunology (Baltimore, Md. : 1950)

Pippig SD, Peña-Rossi C, Long J, Godfrey WR, Fowell DJ, Reiner SL, Birkeland ML, Locksley RM, Barclay AN, Killeen N

Functional screening of an asthma QTL in YAC transgenic mice.

Nature genetics

Symula DJ, Frazer KA, Ueda Y, Denefle P, Stevens ME, Wang ZE, Locksley R, Rubin EM

Impaired NFATc translocation and failure of Th2 development in Itk-deficient CD4+ T cells.

Immunity

Fowell DJ, Shinkai K, Liao XC, Beebe AM, Coffman RL, Littman DR, Locksley RM

Leishmania major infection of inbred mice: unmasking genetic determinants of infectious diseases.

BioEssays : news and reviews in molecular, cellular and developmental biology

Fowell DJ, Locksley RM

Altered ligands reveal limited plasticity in the T cell response to a pathogenic epitope.

The Journal of experimental medicine

Pingel S, Launois P, Fowell DJ, Turck CW, Southwood S, Sette A, Glaichenhaus N, Louis JA, Locksley RM

Susceptibility to infectious diseases: Leishmania as a paradigm.

The Journal of infectious diseases

Locksley RM, Pingel S, Lacy D, Wakil AE, Bix M, Fowell DJ

Construction of polycompetitors for competitive PCR.

Methods in molecular medicine

Corry DB, Locksley RM

Genetic regulation of commitment to interleukin 4 production by a CD4(+) T cell-intrinsic mechanism.

The Journal of experimental medicine

Bix M, Wang ZE, Thiel B, Schork NJ, Locksley RM

Requirement for IL-13 independently of IL-4 in experimental asthma.

Science (New York, N.Y.)

Grünig G, Warnock M, Wakil AE, Venkayya R, Brombacher F, Rennick DM, Sheppard D, Mohrs M, Donaldson DD, Locksley RM, Corry DB

Interferon gamma derived from CD4(+) T cells is sufficient to mediate T helper cell type 1 development.

The Journal of experimental medicine

Wakil AE, Wang ZE, Ryan JC, Fowell DJ, Locksley RM

Disease susceptibility and development of the cytokine repertoire in the murine Leishmania major model.

European cytokine network

Fowell DJ, Bix M, Shinkai K, Lacy D, Locksley RM

Fellowship training in infectious diseases: a report from the regional and national meetings of infectious diseases division chiefs and program directors.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Joiner KA, Powderly WG, Blaser MJ, Klempner MS, Locksley RM, Mandell GL, Preheim LC, Remington JS, Slama TG, Steigbigel NH, Bartlett JG

Requirements for allergen-induced airway hyperreactivity in T and B cell-deficient mice.

Molecular medicine (Cambridge, Mass.)

Corry DB, Grünig G, Hadeiba H, Kurup VP, Warnock ML, Sheppard D, Rennick DM, Locksley RM

Mouse CD1-autoreactive T cells have diverse patterns of reactivity to CD1+ targets.

Journal of immunology (Baltimore, Md. : 1950)

Brossay L, Tangri S, Bix M, Cardell S, Locksley R, Kronenberg M

Macromolecular contrast media-enhanced MRI estimates of microvascular permeability correlate with histopathologic tumor grade.

Academic radiology

Brasch RC, Daldrup H, Shames D, Wendland M, Okuhata Y, Rosenau W

Control of Leishmania major by a monoclonal alpha beta T cell repertoire.

Journal of immunology (Baltimore, Md. : 1950)

Reiner SL, Fowell DJ, Moskowitz NH, Swier K, Brown DR, Brown CR, Turck CW, Scott PA, Killeen N, Locksley RM

Development of CD4+ effector T cells and susceptibility to infectious diseases.

Advances in experimental medicine and biology

Locksley RM, Fowell DJ, Shinkai K, Wakil AE, Lacy D, Bix M

Immunological tolerance to a pancreatic antigen as a result of local expression of TNFalpha by islet beta cells.

Immunity

McSorley SJ, Soldera S, Malherbe L, Carnaud C, Locksley RM, Flavell RA, Glaichenhaus N

Altered immune responses in interleukin 10 transgenic mice.

The Journal of experimental medicine

Hagenbaugh A, Sharma S, Dubinett SM, Wei SH, Aranda R, Cheroutre H, Fowell DJ, Binder S, Tsao B, Locksley RM, Moore KW, Kronenberg M

IL-4 rapidly produced by V beta 4 V alpha 8 CD4+ T cells instructs Th2 development and susceptibility to Leishmania major in BALB/c mice.

Immunity

Launois P, Maillard I, Pingel S, Swihart KG, Xénarios I, Acha-Orbea H, Diggelmann H, Locksley RM, MacDonald HR, Louis JA

Impaired Th2 subset development in the absence of CD4.

Immunity

Fowell DJ, Magram J, Turck CW, Killeen N, Locksley RM

The N-terminal propiece of interleukin 1 alpha is a transforming nuclear oncoprotein.

Proceedings of the National Academy of Sciences of the United States of America

Stevenson FT, Turck J, Locksley RM, Lovett DH

T helper subset differentiation in the absence of invariant chain.

The Journal of experimental medicine

Brown DR, Swier K, Moskowitz NH, Naujokas MF, Locksley RM, Reiner SL

Leishmania major: targeting IL-4 in successful immunomodulation of murine infection.

Experimental parasitology

Wakil AE, Wang ZE, Locksley RM

Beta 2-microglobulin-dependent NK1.1+ T cells are not essential for T helper cell 2 immune responses.

The Journal of experimental medicine

Brown DR, Fowell DJ, Corry DB, Wynn TA, Moskowitz NH, Cheever AW, Locksley RM, Reiner SL

Cytokine production by peripheral blood mononuclear cells in human coccidioidomycosis.

The Journal of infectious diseases

Corry DB, Ampel NM, Christian L, Locksley RM, Galgiani JN

Human placental cytotrophoblasts produce the immunosuppressive cytokine interleukin 10.

The Journal of experimental medicine

Roth I, Corry DB, Locksley RM, Abrams JS, Litton MJ, Fisher SJ

The instructive role of innate immunity in the acquired immune response.

Science (New York, N.Y.)

Fearon DT, Locksley RM

Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity.

The Journal of experimental medicine

Corry DB, Folkesson HG, Warnock ML, Erle DJ, Matthay MA, Wiener-Kronish JP, Locksley RM

Interleukin-12 in murine leishmaniasis--match, flame or fuel?

Research in immunology

Fowell DJ, Wakil AE, Locksley RM

Natural T cells. Cells that co-express NKRP-1 and TCR.

Journal of immunology (Baltimore, Md. : 1950)

Bix M, Locksley RM

Expression cloning of a protective Leishmania antigen.

Science (New York, N.Y.)

Mougneau E, Altare F, Wakil AE, Zheng S, Coppola T, Wang ZE, Waldmann R, Locksley RM, Glaichenhaus N

The development of effector T cell subsets in murine Leishmania major infection.

Ciba Foundation symposium

Locksley RM, Wakil AE, Corry DB, Pingel S, Bix M, Fowell DJ

The regulation of immunity to Leishmania major.

Annual review of immunology

Reiner SL, Locksley RM

Interferon gamma-independent effects of interleukin 12 administered during acute or established infection due to Leishmania major.

Proceedings of the National Academy of Sciences of the United States of America

Wang ZE, Zheng S, Corry DB, Dalton DK, Seder RA, Reiner SL, Locksley RM

Differential effects of blockade of CD28-B7 on the development of Th1 or Th2 effector cells in experimental leishmaniasis.

Journal of immunology (Baltimore, Md. : 1950)

Corry DB, Reiner SL, Linsley PS, Locksley RM

Constructing polycompetitor cDNAs for quantitative PCR (J. Immunol. Methods 165 (1993) 37-46; 173(1994) 133).

Journal of immunological methods

Reiner SL, Zheng S, Corry DB, Locksley RM

Constructing polycompetitor cDNAs for quantitative PCR (J. Immunol. Methods 165 (1993) 37-46).

Journal of immunological methods

Reiner SL, Zheng S, Corry DB, Locksley RM

Th2 cells: help for helminths.

The Journal of experimental medicine

Locksley RM

CD4+ effector cells default to the Th2 pathway in interferon gamma-deficient mice infected with Leishmania major.

The Journal of experimental medicine

Wang ZE, Reiner SL, Zheng S, Dalton DK, Locksley RM

Cytokines in the differentiation of Th1/Th2 CD4+ subsets in leishmaniasis.

Journal of cellular biochemistry

Reiner SL, Locksley RM

Potential role for interleukin-10 in the immunosuppression associated with kala azar.

The Journal of clinical investigation

Holaday BJ, Pompeu MM, Jeronimo S, Texeira MJ, Sousa Ade A, Vasconcelos AW, Pearson RD, Abrams JS, Locksley RM

Constructing polycompetitor cDNAs for quantitative PCR.

Journal of immunological methods

Reiner SL, Zheng S, Corry DB, Locksley RM

Helper T cells without CD4: control of leishmaniasis in CD4-deficient mice.

Science (New York, N.Y.)

Locksley RM, Reiner SL, Hatam F, Littman DR, Killeen N

Reconstitution of Mycobacterium leprae immunity in severe combined immunodeficient mice using a T-cell line.

International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association

Azouaou N, Gelber RH, Abel K, Sasaki DT, Murray LP, Locksley RM, Mohagheghpour N

Targeted activation of CD8 cells and infection of beta 2-microglobulin-deficient mice fail to confirm a primary protective role for CD8 cells in experimental leishmaniasis.

Journal of immunology (Baltimore, Md. : 1950)

Wang ZE, Reiner SL, Hatam F, Heinzel FP, Bouvier J, Turck CW, Locksley RM

The 31-kDa precursor of interleukin 1 alpha is myristoylated on specific lysines within the 16-kDa N-terminal propiece.

Proceedings of the National Academy of Sciences of the United States of America

Stevenson FT, Bursten SL, Fanton C, Locksley RM, Lovett DH

Interleukin 12 in host defense against microbial pathogens.

Proceedings of the National Academy of Sciences of the United States of America

Locksley RM

The worm and the protozoa: stereotyped responses or distinct antigens?

Parasitology today (Personal ed.)

Reiner SL, Locksley RM

Transfected Leishmania expressing biologically active IFN-gamma.

Journal of immunology (Baltimore, Md. : 1950)

Tobin JF, Reiner SL, Hatam F, Zheng S, Leptak CL, Wirth DF, Locksley RM

IL-2 is necessary for the progression of leishmaniasis in susceptible murine hosts.

Journal of immunology (Baltimore, Md. : 1950)

Heinzel FP, Rerko RM, Hatam F, Locksley RM

TH1 and TH2 cell antigen receptors in experimental leishmaniasis.

Science (New York, N.Y.)

Reiner SL, Wang ZE, Hatam F, Scott P, Locksley RM

Myristyl acylation of the tumor necrosis factor alpha precursor on specific lysine residues.

The Journal of experimental medicine

Stevenson FT, Bursten SL, Locksley RM, Lovett DH

Immunology of leishmaniasis.

Current opinion in immunology

Locksley RM, Louis JA

Interleukin 1: the patterns of translation and intracellular distribution support alternative secretory mechanisms.

Journal of cellular physiology

Stevenson FT, Torrano F, Locksley RM, Lovett DH

Tumour necrosis factor alpha restores granulomas and induces parasite egg-laying in schistosome-infected SCID mice.

Nature

Amiri P, Locksley RM, Parslow TG, Sadick M, Rector E, Ritter D, McKerrow JH

Reconstitution of Leishmania immunity in severe combined immunodeficient mice using Th1- and Th2-like cell lines.

Journal of immunology (Baltimore, Md. : 1950)

Holaday BJ, Sadick MD, Wang ZE, Reiner SL, Heinzel FP, Parslow TG, Locksley RM

Production of interferon gamma, interleukin 2, interleukin 4, and interleukin 10 by CD4+ lymphocytes in vivo during healing and progressive murine leishmaniasis.

Proceedings of the National Academy of Sciences of the United States of America

Heinzel FP, Sadick MD, Mutha SS, Locksley RM

Cytokines in fluids from polycystic kidneys.

Kidney international

Gardner KD, Burnside JS, Elzinga LW, Locksley RM

Induction of Th1 and Th2 CD4+ subsets during murine Leishmania major infection.

Research in immunology

Locksley RM, Heinzel FP, Holaday BJ, Mutha SS, Reiner SL, Sadick MD

Cure of murine leishmaniasis with anti-interleukin 4 monoclonal antibody. Evidence for a T cell-dependent, interferon gamma-independent mechanism.

The Journal of experimental medicine

Sadick MD, Heinzel FP, Holaday BJ, Pu RT, Dawkins RS, Locksley RM

The exposure of health care workers to ribavirin aerosol.

JAMA

Guglielmo BJ, Jacobs RA, Locksley RM

Release of interleukin 1 inhibitory activity (contra-IL-1) by human monocyte-derived macrophages infected with human immunodeficiency virus in vitro and in vivo.

The Journal of clinical investigation

Locksley RM, Crowe S, Sadick MD, Heinzel FP, Gardner KD, McGrath MS, Mills J

Acylation of monocyte and glomerular mesangial cell proteins. Myristyl acylation of the interleukin 1 precursors.

The Journal of clinical investigation

Bursten SL, Locksley RM, Ryan JL, Lovett DH

Tumor necrosis factors alpha and beta differ in their capacities to generate interleukin 1 release from human endothelial cells.

Journal of immunology (Baltimore, Md. : 1950)

Locksley RM, Heinzel FP, Shepard HM, Agosti J, Eessalu TE, Aggarwal BB, Harlan JM

Murine cutaneous leishmaniasis: susceptibility correlates with differential expansion of helper T-cell subsets.

Annales de l'Institut Pasteur. Immunology

Locksley RM, Heinzel FP, Sadick MD, Holaday BJ, Gardner KD

Cellular and humoral immunity to Leishmania major in genetically susceptible mice after in vivo depletion of L3T4+ T cells.

Journal of immunology (Baltimore, Md. : 1950)

Sadick MD, Heinzel FP, Shigekane VM, Fisher WL, Locksley RM

Loss of granule myeloperoxidase during in vitro culture of human monocytes correlates with decay in antiprotozoa activity.

The American journal of tropical medicine and hygiene

Locksley RM, Nelson CS, Fankhauser JE, Klebanoff SJ

Isolation and characterization of the receptor on human neutrophils that mediates cellular adherence.

The Journal of biological chemistry

Hickstein DD, Ozols J, Williams SA, Baenziger JU, Locksley RM, Roth GJ

Expression of leukocyte adherence-related glycoproteins during differentiation of HL-60 promyelocytic leukemia cells.

Journal of immunology (Baltimore, Md. : 1950)

Hickstein DD, Smith A, Fisher W, Beatty PG, Schwartz BR, Harlan JM, Root RK, Locksley RM

Monoclonal antibodies binding to the human neutrophil C3bi receptor have disparate functional effects.

Blood

Hickstein DD, Locksley RM, Beatty PG, Smith A, Stone DM, Root RK

Infection with varicella-zoster virus after marrow transplantation.

The Journal of infectious diseases

Locksley RM, Flournoy N, Sullivan KM, Meyers JD

Alteration of leukotriene release by macrophages ingesting Toxoplasma gondii.

Proceedings of the National Academy of Sciences of the United States of America

Locksley RM, Fankhauser J, Henderson WR

Development of cellular immunity in cutaneous leishmaniasis due to Leishmania tropica.

The Journal of infectious diseases

Sadick MD, Locksley RM, Raff HV

Interaction of primate alveolar macrophages and Legionella pneumophila.

The Journal of clinical investigation

Jacobs RF, Locksley RM, Wilson CB, Haas JE, Klebanoff SJ

Oxidative response of phagocytes to parasite invasion.

Ciba Foundation symposium

Klebanoff SJ, Locksley RM, Jong EC, Rosen H

Susceptibility of Legionella pneumophila to oxygen-dependent microbicidal systems.

Journal of immunology (Baltimore, Md. : 1950)

Locksley RM, Jacobs RF, Wilson CB, Weaver WM, Klebanoff SJ

Multiply antibiotic-resistant Staphylococcus aureus: introduction, transmission, and evolution of nosocomial infection.

Annals of internal medicine

Locksley RM, Cohen ML, Quinn TC, Tompkins LS, Coyle MB, Kirihara JM, Counts GW

Thiazide-induced hyponatremia associated with death or neurologic damage in outpatients.

The American journal of medicine

Ashraf N, Locksley R, Arieff AI

Prognostic grading and significance of ventricular premature beats after recovery from myocardial infarction.

Circulation

Moss AJ, DeCamilla J, Mietlowski W, Greene WA, Goldstein S, Locksley R

Two improvements in the preparation of cardiac microsomes.

Recent advances in studies on cardiac structure and metabolism

Stam AC, Sole M, Locksley R, Weglicki WB, Sonnenblick EH

Research Area: 
Adipocyte and Metabolism