Galateia Kazakia, PhD

Human Metabolism Core Co-Director
Radiology
+1 415 353-4534

Galateia J. Kazakia, PhD, is Professor in Residence and Director of the Bone Quality Research Laboratory in the Department of Radiology and Biomedical Imaging at the University of California, San Francisco. Dr. Kazakia serves as the Faculty Director of the Quantitative Musculoskeletal-Imaging Core, Director of the UCSF Core Center for Musculoskeletal Biology and Medicine (CCMBM) Imaging Core, and Co-Director of the Nutrition and Obesity Research Center (NORC) Human Metabolism Core. Dr. Kazakia received her BS in Mechanical Engineering from Cornell University in Ithaca, New York in 1995. She completed her PhD in Mechanical Engineering (with an emphasis on Bone Biomechanics) from the University of California, Berkeley in 2004. Dr. Kazakia was awarded an NIH F32 postdoctoral fellowship to develop bone imaging techniques, performing this work in the Musculoskeletal Quantitative Imaging Research group at UCSF. Dr. Kazakia joined the UCSF Department of Radiology and Biomedical Imaging as an Assistant Professor in Residence in 2009.

Dr. Kazakia’s research is focused on the assessment of bone quality using both in vivo and ex vivo imaging tools, spanning the hierarchical levels of bone structure and composition. Through her research she aims to characterize changes occurring in the skeleton in response to aging and disease, to discover biological mechanisms of these changes, and to understand the impact skeletal changes have on bone strength and fracture risk.

Dr. Kazakia is an active member of the American Society for Bone and Mineral Research, the American Association for the Advancement of Science, and the Orthopaedic Research Society. Dr. Kazakia serves as a reviewer for >10 scientific journals, and she has published numerous peer-reviewed articles and conference abstracts.

Expertise:
Musculoskeletal Radiology

Specialty:
Musculoskeletal imaging, musculoskeletal diseases, CT, MRI, HR-pQCT, microCT, FTIR

Professional Interests:
Mineralization, bone quality, bone architecture, bone micro-damage, biomechanics, mechanical properties, Fourier transform infrared (FTIR) spectroscopy, high-resolution computed tomography (CT), magnetic resonance imaging (MRI), MR spectroscopy, muscle and fat quality assessment

Education and Training:
• Bachelor of Science: Cornell University, Ithaca, New York - Mechanical Engineering
• Masters of Science: University of California, Berkeley - Mechanical Engineering
• Doctor of Philosophy: University of California, Berkeley - Mechanical Engineering

Publications: 

HR-pQCT cross-calibration using standard vs. Laplace-hamming Binarization approach.

JBMR plus

Saghi Sadoughi, Aditya Subramanian, Gabby Ramil, Minhao Zhou, Andrew J Burghardt, Galateia J Kazakia

Calcium phosphate nanoclusters modify periodontium remodeling and minimize orthodontic relapse.

bioRxiv : the preprint server for biology

Cuylear DL, Fu ML, Chau JC, Kharbikar B, Kazakia GJ, Jheon A, Habelitz S, Kapila SD, Desai TA

Superresolution of Real-World Multiscale Bone CT Verified with Clinical Bone Measures.

Lecture Notes in Computer Science

Sophia W. Bardenfleth, Vedrana A. Dahl, Chiara Villa, Galateia Kazakia, Anders B. Dahl

Skeletal effects of sleeve gastrectomy, by sex and menopausal status and in comparison to Roux-en-Y gastric bypass surgery.

medRxiv : the preprint server for health sciences

Wu KC, Wu PH, Kazakia G, Patel S, Black DM, Lang TF, Kim TY, King NJ, Hoffman TJ, Chang H, Linfield G, Palilla S, Rogers SJ, Carter JT, Posselt AM, Schafer AL

Microvascular disease not type 2 diabetes is associated with increased cortical porosity: A study of cortical bone microstructure and intracortical vessel characteristics.

Bone Reports

Löffler MT, Wu PH, Pirmoazen AM, Joseph GB, Stewart JM, Saeed I, Liu J, Schafer AL, Schwartz AV, Link TM, Kazakia GJ

Diabetes Risk Factors and Bone Microarchitecture as Assessed by High-Resolution Peripheral Quantitative Computed Tomography in Adults With Long-Standing Type 1 Diabetes.

Diabetes care

Sinha Gregory N, Burghardt AJ, Backlund JC, Rubin MR, Bebu I, Braffett BH, Kenny DJ, Link TM, Kazakia GJ, Barnie A, Lachin JM, Gubitosi-Klug R, de Boer IH, Schwartz AV, DCCT/EDIC Research Group

Bone marrow adiposity alterations in type 2 diabetes are sex-specific and associated with serum lipid levels.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Wu PH, Joseph G, Saeed I, Pirmoazen AM, Kenny K, Kim TY, Schafer AL, Schwartz AV, Li X, Link TM, Kazakia GJ

A Laplace-Hamming Binarization Approach for Second-Generation HR-pQCT Rescues Fine Feature Segmentation.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Sadoughi S, Subramanian A, Ramil G, Burghardt AJ, Kazakia GJ

Differential bone adaptation to mechanical unloading and reloading in young, old, and osteocyte deficient mice.

Bone

Cunningham HC, Orr S, Murugesh DK, Hsia AW, Osipov B, Go L, Wu PH, Wong A, Loots GG, Kazakia GJ, Christiansen BA

Bone marrow adipose tissue composition and glycemic improvements after gastric bypass surgery.

Bone Reports

Kim TY, Schwartz AV, Li X, Xu K, Kazakia GJ, Grunfeld C, Nissenson RA, Shoback DM, Schafer AL

People living with HIV have low trabecular bone mineral density, high bone marrow adiposity, and poor trabecular bone microarchitecture at the proximal femur.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

Carballido-Gamio J, Posadzy M, Wu PH, Kenny K, Saeed I, Link TM, Tien PC, Krug R, Kazakia GJ

Cortical bone loss following gastric bypass surgery is not primarily endocortical.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Sadoughi S, Pasco C, Joseph GB, Wu PH, Schafer AL, Kazakia GJ

A timeseries analysis of the fracture callus extracellular matrix proteome during bone fracture healing.

Journal of life sciences (Westlake Village, Calif.)

Erickson CB, Hill R, Pascablo D, Kazakia G, Hansen K, Bahney C

Augmenting Osteoporosis Imaging with Machine Learning.

Current osteoporosis reports

Pedoia V, Caliva F, Kazakia G, Burghardt AJ, Majumdar S

HR-pQCT-based regional analysis reveals tibial spatial variability in cortical bone tissue quality in type 2 diabetic postmenopausal women with and without history of fragility fractures.

Bone Reports

Ursula Heilmeier, Courtney Pasco, Meliss Yilmaz, Andrew J. Burghardt, Gabby B. Joseph, Thomas M. Link, Galateia J. Kazakia

Microstructural abnormalities are evident by histology but not HR-pQCT at the periosteal cortex of the human tibia under CVD and T2D conditions.

Medicine in Novel Technology and Devices

Garita B, Maligro J, Sadoughi S, Wu PH, Liebenberg E, Horvai A, Link TM, Kazakia GJ

Soft tissue variations influence HR-pQCT density measurements in a spatially dependent manner.

Bone

Wu PH, Gupta T, Chang H, Petrenko D, Schafer A, Kazakia G

Update on Imaging-Based Measurement of Bone Mineral Density and Quality.

Current rheumatology reports

Link TM, Kazakia G

Factors associated with bone microstructural alterations assessed by HR-pQCT in long-term HIV-infected individuals.

Bone

Foreman SC, Wu PH, Kuang R, John MD, Tien PC, Link TM, Krug R, Kazakia GJ

Cortical bone vessel identification and quantification on contrast-enhanced MR images.

Quantitative imaging in medicine and surgery

Wu PH, Gibbons M, Foreman SC, Carballido-Gamio J, Han M, Krug R, Liu J, Link TM, Kazakia GJ

Detection of Lumbar Spine Osseous Metastases Using Dual-Energy CT: Phantom Results and Preliminary Clinical Validation.

AJR. American journal of roentgenology

Huang HC, Srinivasan R, Sun Y, Kazakia GJ, Lin PC, Yeh BM

Cartilage Endplate Thickness Variation Measured by Ultrashort Echo-Time MRI Is Associated With Adjacent Disc Degeneration.

Spine

Berg-Johansen B, Han M, Fields AJ, Liebenberg EC, Lim BJ, Larson PE, Gunduz-Demir C, Kazakia GJ, Krug R, Lotz JC

High-Impact Mechanical Loading Increases Bone Material Strength in Postmenopausal Women-A 3-Month Intervention Study.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Sundh D, Nilsson M, Zoulakis M, Pasco C, Yilmaz M, Kazakia GJ, Hellgren M, Lorentzon M

Effects of Gastric Bypass Surgery on Bone Mass and Microarchitecture Occur Early and Particularly Impact Postmenopausal Women.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Schafer AL, Kazakia GJ, Vittinghoff E, Stewart L, Rogers SJ, Kim TY, Carter JT, Posselt AM, Pasco C, Shoback DM, Black DM

Trabecular bone microstructure is impaired in the proximal femur of human immunodeficiency virus-infected men with normal bone mineral density.

Quantitative imaging in medicine and surgery

Kazakia GJ, Carballido-Gamio J, Lai A, Nardo L, Facchetti L, Pasco C, Zhang CA, Han M, Parrott AH, Tien P, Krug R

A modular approach to creating large engineered cartilage surfaces.

Journal of biomechanics

Ford AC, Chui WF, Zeng AY, Nandy A, Liebenberg E, Carraro C, Kazakia G, Alliston T, O'Connell GD

Role of Osteoblast Gi Signaling in Age-Related Bone Loss in Female Mice.

Endocrinology

Millard SM, Wang L, Wattanachanya L, O'Carroll D, Fields AJ, Pang J, Kazakia G, Lotz JC, Nissenson RA

Statistical Parametric Mapping of HR-pQCT Images: A Tool for Population-Based Local Comparisons of Micro-Scale Bone Features.

Annals of biomedical engineering

Carballido-Gamio J, Bonaretti S, Kazakia GJ, Khosla S, Majumdar S, Lang TF, Burghardt AJ

Cortical bone laminar analysis reveals increased midcortical and periosteal porosity in type 2 diabetic postmenopausal women with history of fragility fractures compared to fracture-free diabetics.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

Heilmeier U, Cheng K, Pasco C, Parrish R, Nirody J, Patsch JM, Zhang CA, Joseph GB, Burghardt AJ, Schwartz AV, Link TM, Kazakia G

FES-rowing attenuates bone loss following spinal cord injury as assessed by HR-pQCT.

Spinal cord series and cases

Gibbons RS, Beaupre GS, Kazakia GJ

Kartogenin treatment prevented joint degeneration in a rodent model of osteoarthritis: A pilot study.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Mohan G, Magnitsky S, Melkus G, Subburaj K, Kazakia G, Burghardt AJ, Dang A, Lane NE, Majumdar S

Distinct Tissue Mineral Density in Plate- and Rod-like Trabeculae of Human Trabecular Bone.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Wang J, Kazakia GJ, Zhou B, Shi XT, Guo XE

Spatial distribution of intracortical porosity varies across age and sex.

Bone

Nirody JA, Cheng KP, Parrish RM, Burghardt AJ, Majumdar S, Link TM, Kazakia GJ

Effect of intraspecimen spatial variation in tissue mineral density on the apparent stiffness of trabecular bone.

Journal of biomechanical engineering

Kaynia N, Soohoo E, Keaveny TM, Kazakia GJ

Validation of bone marrow fat quantification in the presence of trabecular bone using MRI.

Journal of magnetic resonance imaging : JMRI

Gee CS, Nguyen JT, Marquez CJ, Heunis J, Lai A, Wyatt C, Han M, Kazakia G, Burghardt AJ, Karampinos DC, Carballido-Gamio J, Krug R

Population-based local multi-parametric comparisons of HR-pQCT studies.

Journal of Orthopaedic Translation

Julio Carballido-Gamio, Serena Bonaretti, Galateia J. Kazakia, Sundeep Khosla, Thomas F. Lang, Andrew J. Burghardt

How tough is brittle bone? Investigating osteogenesis imperfecta in mouse bone.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Carriero A, Zimmermann EA, Paluszny A, Tang SY, Bale H, Busse B, Alliston T, Kazakia G, Ritchie RO, Shefelbine SJ

The influence of disuse on bone microstructure and mechanics assessed by HR-pQCT.

Bone

Kazakia GJ, Tjong W, Nirody JA, Burghardt AJ, Carballido-Gamio J, Patsch JM, Link T, Feeley BT, Ma CB

Alterations of mass density and 3D osteocyte lacunar properties in bisphosphonate-related osteonecrotic human jaw bone, a synchrotron µCT study.

PloS one

Hesse B, Langer M, Varga P, Pacureanu A, Dong P, Schrof S, Männicke N, Suhonen H, Olivier C, Maurer P, Kazakia GJ, Raum K, Peyrin F

Structural analysis of cortical porosity applied to HR-pQCT data.

Medical physics

Tjong W, Nirody J, Burghardt AJ, Carballido-Gamio J, Kazakia GJ

Multicenter precision of cortical and trabecular bone quality measures assessed by high-resolution peripheral quantitative computed tomography.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Burghardt AJ, Pialat JB, Kazakia GJ, Boutroy S, Engelke K, Patsch JM, Valentinitsch A, Liu D, Szabo E, Bogado CE, Zanchetta MB, McKay HA, Shane E, Boyd SK, Bouxsein ML, Chapurlat R, Khosla S, Majumdar S

The role of oxygen during fracture healing.

Bone

Lu C, Saless N, Wang X, Sinha A, Decker S, Kazakia G, Hou H, Williams B, Swartz HM, Hunt TK, Miclau T, Marcucio RS

Bone and cartilage demonstrate changes localized to bone marrow edema-like lesions within osteoarthritic knees.

Osteoarthritis and cartilage

Kazakia GJ, Kuo D, Schooler J, Siddiqui S, Shanbhag S, Bernstein G, Horvai A, Majumdar S, Ries M, Li X

Noninvasive imaging of bone microarchitecture.

Annals of the New York Academy of Sciences

Patsch JM, Burghardt AJ, Kazakia G, Majumdar S

Longitudinal in vivo HR-pQCT assessment of the influence of non-weight bearing on bone quality.

Bone

W. Tjong, M. Sode, A. Burghardt, S. Majumdar, B. Feeley, B. Ma, G. Kazakia

Mineral composition is altered by osteoblast expression of an engineered G(s)-coupled receptor.

Calcified tissue international

Kazakia GJ, Speer D, Shanbhag S, Majumdar S, Conklin BR, Nissenson RA, Hsiao EC

Variations in morphological and biomechanical indices at the distal radius in subjects with identical BMD.

Journal of biomechanics

Kazakia GJ, Burghardt AJ, Link TM, Majumdar S

Longitudinal evaluation of the effects of alendronate on MRI bone microarchitecture in postmenopausal osteopenic women.

Bone

Folkesson J, Goldenstein J, Carballido-Gamio J, Kazakia G, Burghardt AJ, Rodriguez A, Krug R, de Papp AE, Link TM, Majumdar S

A longitudinal HR-pQCT study of alendronate treatment in postmenopausal women with low bone density: Relations among density, cortical and trabecular microarchitecture, biomechanics, and bone turnover.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Burghardt AJ, Kazakia GJ, Sode M, de Papp AE, Link TM, Majumdar S

Age- and gender-related differences in the geometric properties and biomechanical significance of intracortical porosity in the distal radius and tibia.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Burghardt AJ, Kazakia GJ, Ramachandran S, Link TM, Majumdar S

In vivo evaluation of the presence of bone marrow in cortical porosity in postmenopausal osteopenic women.

Annals of biomedical engineering

Goldenstein J, Kazakia G, Majumdar S

Three-dimensional surface texture visualization of bone tissue through epifluorescence-based serial block face imaging.

Journal of microscopy

Slyfield CR, Niemeyer KE, Tkachenko EV, Tomlinson RE, Steyer GG, Patthanacharoenphon CG, Kazakia GJ, Wilson DL, Hernandez CJ

392 BONE MARROW EDEMA-LIKE LESIONS IN OSTEOARTHRITIC SUBJECTS EXHIBIT ALTERED TRABECULAR STRUCTURE AND COMPOSITION.

Osteoarthritis and cartilage

G.J. Kazakia, D. Kuo, J. Schooler, S. Shanbhag, S. Majumdar, M. Ries, X. Li

Assessment of trabecular bone structure using MDCT: comparison of 64- and 320-slice CT using HR-pQCT as the reference standard.

European radiology

Issever AS, Link TM, Kentenich M, Rogalla P, Burghardt AJ, Kazakia GJ, Majumdar S, Diederichs G

Automated simulation of areal bone mineral density assessment in the distal radius from high-resolution peripheral quantitative computed tomography.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

Burghardt AJ, Kazakia GJ, Link TM, Majumdar S

Quantitative assessment of bone tissue mineralization with polychromatic micro-computed tomography.

Calcified tissue international

Burghardt AJ, Kazakia GJ, Laib A, Majumdar S

In vivo determination of bone structure in postmenopausal women: a comparison of HR-pQCT and high-field MR imaging.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Kazakia GJ, Hyun B, Burghardt AJ, Krug R, Newitt DC, de Papp AE, Link TM, Majumdar S

Assessment of trabecular bone structure comparing magnetic resonance imaging at 3 Tesla with high-resolution peripheral quantitative computed tomography ex vivo and in vivo.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

Krug R, Carballido-Gamio J, Burghardt AJ, Kazakia G, Hyun BH, Jobke B, Banerjee S, Huber M, Link TM, Majumdar S

Validity of serial milling-based imaging system for microdamage quantification.

Bone

Bigley RF, Singh M, Hernandez CJ, Kazakia GJ, Martin RB, Keaveny TM

Automated high-resolution three-dimensional fluorescence imaging of large biological specimens.

Journal of microscopy

Kazakia GJ, Lee JJ, Singh M, Bigley RF, Martin RB, Keaveny TM

Effects of in vitro bone formation on the mechanical properties of a trabeculated hydroxyapatite bone substitute.

Journal of biomedical materials research. Part A

Kazakia GJ, Nauman EA, Ebenstein DM, Halloran BP, Keaveny TM

New imaging technologies in the diagnosis of osteoporosis.

Reviews in endocrine & metabolic disorders

Kazakia GJ, Majumdar S

Research Area: 
Bio-imaging
Clinical Research