Brian Feldman, MD, PhD

Pilot & Feasibility Core Director

Pediatrics

+1 415 514-0610

Brian Feldman, MD, PhD
Walter L. Miller Distinguished Professor
University of California, San Francisco
Department of Pediatrics
Division of Pediatric Endocrinology

A major focus of the Feldman Laboratory is to elucidate previously unrecognized paracrine and endocrine signaling pathways that regulate stem cell fate and differentiation decisions. We are particularly interested in identifying novel pathways that modulate body composition and metabolism. We apply molecular, cellular and in vivo approaches to define these physiological signals as well as examine how perturbations in these pathways can lead to diseases such as diabetes.

Publications:

White adipocytes in subcutaneous fat depots require KLF15 for maintenance in preclinical models.

The Journal of clinical investigation

Li L, Feldman BJ

Repurposing mebendazole against triple-negative breast cancer CNS metastasis.

Journal of neuro-oncology

Rodrigues AJ, Chernikova SB, Wang Y, Trinh TTH, Solow-Cordero DE, Alexandrova L, Casey KM, Alli E, Aggarwal A, Quill T, Koegel AK, Feldman BJ, Ford JM, Hayden-Gephart M

Repurposing mebendazole against triple-negative breast cancer leptomeningeal disease.

Research square

Rodrigues A, Chernikova SB, Wang Y, Trinh TTH, Solow-Cordero DE, Alexandrova L, Casey KM, Alli E, Aggarwal A, Quill T, Koegel A, Feldman BJ, Ford JM, Hayden-Gephart M

Glucocorticoid Signaling and the Impact of High-Fat Diet on Adipogenesis in Vivo.

Steroids

Babel NK, Feldman BJ

Quantification of cell energetics in human subcutaneous adipose progenitor cells after target gene knockdown.

STAR protocols

Li L, Gunewardena AM, Nyima T, Feldman BJ

Identification of an adipose tissue-resident pro-preadipocyte population.

Cell reports

Chen M, Kim S, Li L, Chattopadhyay S, Rando TA, Feldman BJ

MYH9 facilitates autoregulation of adipose tissue depot development.

JCI insight

Cheung SY, Sayeed M, Nakuluri K, Li L, Feldman BJ

A Novel Radioligand Reveals Tissue Specific Pharmacological Modulation of Glucocorticoid Receptor Expression with Positron Emission Tomography.

ACS chemical biology

Huang Y, Zhao N, Wang YH, Truillet C, Wei J, Blecha JE, VanBrocklin HF, Seo Y, Sayeed M, Feldman BJ, Aggarwal R, Behr SC, Shao H, Wilson DM, Villanueva-Meyer JE, Gestwicki JE, Evans MJ

A novel platform for isotype-specific testing of autoantibodies.

PloS one

Carter KL, Treurnicht A, Davis KL, Kumar RB, Feldman BJ

A context-specific circadian clock in adipocyte precursor cells modulates adipogenesis.

Adipocyte

Jung Y, Feldman BJ

The Circadian Clock Regulates Adipogenesis by a Per3 Crosstalk Pathway to Klf15.

Cell reports

Aggarwal A, Costa MJ, Rivero-Gutiérrez B, Ji L, Morgan SL, Feldman BJ

Macrophage-released ADAMTS1 promotes muscle stem cell activation.

Nature communications

Du H, Shih CH, Wosczyna MN, Mueller AA, Cho J, Aggarwal A, Rando TA, Feldman BJ

Adamts1 responds to systemic cues and gates adipogenesis.

Adipocyte

Wong JC, Feldman BJ

Identification of tumor-autonomous and indirect effects of vitamin D action that inhibit breast cancer growth and tumor progression.

The Journal of steroid biochemistry and molecular biology

Aggarwal A, Feldman D, Feldman BJ

Amphetamines promote mitochondrial dysfunction and DNA damage in pulmonary hypertension.

JCI insight

Chen PI, Cao A, Miyagawa K, Tojais NF, Hennigs JK, Li CG, Sweeney NM, Inglis AS, Wang L, Li D, Ye M, Feldman BJ, Rabinovitch M

A glucocorticoid- and diet-responsive pathway toggles adipocyte precursor cell activity in vivo.

Science signaling

Wong JC, Krueger KC, Costa MJ, Aggarwal A, Du H, McLaughlin TL, Feldman BJ

Tumor Autonomous Effects of Vitamin D Deficiency Promote Breast Cancer Metastasis.

Endocrinology

Williams JD, Aggarwal A, Swami S, Krishnan AV, Ji L, Albertelli MA, Feldman BJ

Vitamin D mitigates the adverse effects of obesity on breast cancer in mice.

Endocrine-related cancer

Swami S, Krishnan AV, Williams J, Aggarwal A, Albertelli MA, Horst RL, Feldman BJ, Feldman D

Vitamin D Regulates Fatty Acid Composition in Subcutaneous Adipose Tissue Through Elovl3.

Endocrinology

Ji L, Gupta M, Feldman BJ

Mifepristone Treatment of Cushing's Syndrome in a Pediatric Patient.

Pediatrics

Banerjee RR, Marina N, Katznelson L, Feldman BJ

Inhibition of Mouse Breast Tumor-Initiating Cells by Calcitriol and Dietary Vitamin D.

Molecular cancer therapeutics

Jeong Y, Swami S, Krishnan AV, Williams JD, Martin S, Horst RL, Albertelli MA, Feldman BJ, Feldman D, Diehn M

BMPR2 preserves mitochondrial function and DNA during reoxygenation to promote endothelial cell survival and reverse pulmonary hypertension.

Cell metabolism

Diebold I, Hennigs JK, Miyagawa K, Li CG, Nickel NP, Kaschwich M, Cao A, Wang L, Reddy S, Chen PI, Nakahira K, Alcazar MA, Hopper RK, Ji L, Feldman BJ, Rabinovitch M