James Bayrer, MD, PhD

Assoc Professor in Residence
Pediatrics
+1 415 502-2352

As a pediatric gastroenterologist and physician scientist, I am keenly aware of the challenges faced by our pediatric population. The intestinal epithelium comprises the human body’s greatest environmentally exposed surface and is the largest sensory and endocrine organ. My research utilizes human intestinal organoids and animal models to understand how the intestine senses and responds to both regular and inflammatory stimuli. By investigating the molecular pathways involved, we aim to discover new ways to promote intestinal wound healing and modulate the signals contributing to visceral pain syndromes.

Publications: 

Gut enterochromaffin cells drive visceral pain and anxiety.

Nature

Bayrer JR, Castro J, Venkataraman A, Touhara KK, Rossen ND, Morrie RD, Maddern J, Hendry A, Braverman KN, Garcia-Caraballo S, Schober G, Brizuela M, Castro Navarro FM, Bueno-Silva C, Ingraham HA, Brierley SM, Julius D

A thermogenic fat-epithelium cell axis regulates intestinal disease tolerance.

Proceedings of the National Academy of Sciences of the United States of America

Man K, Bowman C, Braverman KN, Escalante V, Tian Y, Bisanz JE, Ganeshan K, Wang B, Patterson A, Bayrer JR, Turnbaugh PJ, Chawla A

SPARC - Mapping Gut-Spinal Cord Connections in Visceral Pain.

The FASEB Journal

Ryan David Morrie, James Bayrer, Stuart Brierley, Holly Ingraham, David Julius

Estrogen signaling in arcuate Kiss1 neurons suppresses a sex-dependent female circuit promoting dense strong bones.

Herber CB, Krause WC, Wang L, Bayrer JR, Li A, Schmitz M, Fields A, Ford B, Zhang Z, Reid MS, Nomura DK, Nissenson RA, Correa SM, Ingraham HA

Estrogen signaling in arcuate Kiss1 neurons suppresses a sex-dependent female circuit promoting dense strong bones.

Nature communications

Herber CB, Krause WC, Wang L, Bayrer JR, Li A, Schmitz M, Fields A, Ford B, Zhang Z, Reid MS, Nomura DK, Nissenson RA, Correa SM, Ingraham HA

Advances in Enteric Neurobiology: The "Brain" in the Gut in Health and Disease.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Kulkarni S, Ganz J, Bayrer J, Becker L, Bogunovic M, Rao M

LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival.

Nature communications

Bayrer JR, Wang H, Nattiv R, Suzawa M, Escusa HS, Fletterick RJ, Klein OD, Moore DD, Ingraham HA

Enterochromaffin Cells Are Gut Chemosensors that Couple to Sensory Neural Pathways.

Cell

Bellono NW, Bayrer JR, Leitch DB, Castro J, Zhang C, O'Donnell TA, Brierley SM, Ingraham HA, Julius D

Intestinal Organoids: New Frontiers in the Study of Intestinal Disease and Physiology.

Journal of pediatric gastroenterology and nutrition

Wallach TE, Bayrer JR

Tu1824 Targeting Intestinal Stem Cells to Promote Healing in Inflammatory Bowel Disease.

Gastroenterology

James R. Bayrer, Robert Fletterick, Holly Ingraham

Silencing LRH-1 in colon cancer cell lines impairs proliferation and alters gene expression programs.

Proceedings of the National Academy of Sciences of the United States of America

Bayrer JR, Mukkamala S, Sablin EP, Webb P, Fletterick RJ

Sa1803 Dissecting the Oncogenic Activity of the Nuclear Receptor LRH-1 in the Colon.

Gastroenterology

James R. Bayrer, Sridevi Mukkamala, Elena Sablin, Robert Fletterick

Expression, crystallization and preliminary X-ray characterization of the Drosophila transcription factor Doublesex.

Acta crystallographica. Section D, Biological crystallography

Bayrer J, Wan Z, Li B, Weiss MA

Research Area: 
Adipocyte and Metabolism
Central Regulation