Jeremy Reiter, MD, PhD

Genetics & Genomics Core Director
Biochemistry and Biophysics
+1 415 476-0156

Jeremy Reiter is the chairperson of the Department of Biochemistry and Biophysics. His lab investigates how cilia form, signal and function in intercellular communication. Their achievements include:
1. The discovery that Smoothened, a critical component of the Hedgehog pathway, localizes to and works in cilia. This was the first demonstration that the Hedgehog signal transduction machinery functions at cilia.
2. They were the first to show that cancers can be ciliated and that cancers can require cilia for growth.
3. They helped show that the region at the base of the cilium called the transition zone is a gate that controls ciliary composition. For example, the transition zone regulates the ciliary localization of Smoothened and, therefore, is required for Hedgehog signaling.
4. They identified many transition zone components and discovered that some ciliopathies are caused by inherited human mutations in these transition zone components.
5. They found a phosphoinositide that marks the ciliary membrane and helps direct which proteins localize to cilia. This was the first identification of a specific cilia-enriched lipid.
6. They investigated how cilia regulate adult tissue homeostasis. Recently, they have shown how cilia of hypothalamic neurons signal to regulate satiety and how cilia restrict adipogenesis.

Publications: 

Variants in tubule epithelial regulatory elements mediate most heritable differences in human kidney function.

bioRxiv : the preprint server for biology

Loeb GB, Kathail P, Shuai R, Chung R, Grona RJ, Peddada S, Sevim V, Federman S, Mader K, Chu A, Davitte J, Du J, Gupta AR, Ye CJ, Shafer S, Przybyla L, Rapiteanu R, Ioannidis N, Reiter JF

An alternative cell cycle coordinates multiciliated cell differentiation.

Nature

Choksi SP, Byrnes LE, Konjikusic MJ, Tsai BWH, Deleon R, Lu Q, Westlake CJ, Reiter JF

Rab35 Is Required for Embryonic Development and Kidney and Ureter Homeostasis through Regulation of Epithelial Cell Junctions.

Journal of the American Society of Nephrology : JASN

Clearman KR, Timpratoom N, Patel D, Rains AB, Haycraft CJ, Croyle MJ, Reiter JF, Yoder BK

Emerging mechanistic understanding of cilia function in cellular signalling.

Nature reviews. Molecular cell biology

Hilgendorf KI, Myers BR, Reiter JF

GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway.

Nature structural & molecular biology

Hoppe N, Harrison S, Hwang SH, Chen Z, Karelina M, Deshpande I, Suomivuori CM, Palicharla VR, Berry SP, Tschaikner P, Regele D, Covey DF, Stefan E, Marks DS, Reiter JF, Dror RO, Evers AS, Mukhopadhyay S, Manglik A

ADPKD-Causing Missense Variants in Polycystin-1 Disrupt Cell Surface Localization or Polycystin Channel Function.

bioRxiv : the preprint server for biology

Ha K, Loeb GB, Park M, Pinedo A, Park CH, Brandes N, Ritu F, Ye CJ, Reiter JF, Delling M

Primary cilia control oligodendrocyte precursor cell proliferation in white matter injury via Hedgehog-independent CREB signaling.

Cell reports

Hoi KK, Xia W, Wei MM, Ulloa Navas MJ, Garcia Verdugo JM, Nachury MV, Reiter JF, Fancy SPJ

Polycystin-2 dependent transcriptome reveals early response of autosomal dominant polycystic kidney disease.

Physiological genomics

Jung HJ, Dixon EE, Coleman R, Watnick T, Reiter J, Outeda P, Cebotaru V, Woodward OM, Welling PA

Rab35 is required for embryonic development and kidney and ureter homeostasis through regulation of epithelial cell junctions.

bioRxiv : the preprint server for biology

Clearman KR, Timpratoom N, Patel D, Rains AB, Haycraft CJ, Croyle MJ, Reiter JF, Yoder BK

An RFX transcription factor regulates ciliogenesis in the closest living relatives of animals.

Current biology : CB

Coyle MC, Tajima AM, Leon F, Choksi SP, Yang A, Espinoza S, Hughes TR, Reiter JF, Booth DS, King N

Hedgehog target genes regulate lipid metabolism to drive basal cell carcinoma and medulloblastoma.

Research square

Daggubati V, Vykunta A, Choudhury A, Qadeer Z, Mirchia K, Saulnier O, Zakimi N, Hines K, Paul M, Wang L, Jura N, Xu L, Reiter J, Taylor M, Weiss W, Raleigh D

GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway.

bioRxiv : the preprint server for biology

Hoppe N, Harrison S, Hwang SH, Chen Z, Karelina M, Deshpande I, Suomivuori CM, Palicharla VR, Berry SP, Tschaikner P, Regele D, Covey DF, Stefan E, Marks DS, Reiter J, Dror RO, Evers AS, Mukhopadhyay S, Manglik A

Physiological Condition Dependent Changes in Ciliary GPCR Localization in the Brain.

eNeuro

Brewer KM, Engle SE, Bansal R, Brewer KK, Jasso KR, McIntyre JC, Vaisse C, Reiter JF, Berbari NF

Centriolar satellites expedite mother centriole remodeling to promote ciliogenesis.

eLife

Hall EA, Kumar D, Prosser SL, Yeyati PL, Herranz-P?rez V, Garc?a-Verdugo JM, Rose L, McKie L, Dodd DO, Tennant PA, Megaw R, Murphy LC, Ferreira MF, Grimes G, Williams L, Quidwai T, Pelletier L, Reiter JF, Mill P

MRAP2 regulates energy homeostasis by promoting primary cilia localization of MC4R.

JCI insight

Bernard A, Ojeda Naharros I, Yue X, Mifsud F, Blake A, Bourgain-Guglielmetti F, Ciprin J, Zhang S, McDaid E, Kim K, Nachury MV, Reiter JF, Vaisse C

Zika virus alters centrosome organization to suppress the innate immune response.

EMBO reports

Kodani A, Knopp KA, Di Lullo E, Retallack H, Kriegstein AR, DeRisi JL, Reiter JF

A kinesin mimics DNA.

Nature cell biology

Kumar D, Reiter JF

The Intimate Connection Between Lipids and Hedgehog Signaling.

Frontiers in cell and developmental biology

Nguyen TD, Truong ME, Reiter JF

The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans.

Science (New York, N.Y.)

Tabula Sapiens Consortium*, Jones RC, Karkanias J, Krasnow MA, Pisco AO, Quake SR, Salzman J, Yosef N, Bulthaup B, Brown P, Harper W, Hemenez M, Ponnusamy R, Salehi A, Sanagavarapu BA, Spallino E, Aaron KA, Concepcion W, Gardner JM, Kelly B, Neidlinger N, Wang Z, Crasta S, Kolluru S, Morri M, Pisco AO, Tan SY, Travaglini KJ, Xu C, Alcántara-Hernández M, Almanzar N, Antony J, Beyersdorf B, Burhan D, Calcuttawala K, Carter MM, Chan CKF, Chang CA, Chang S, Colville A, Crasta S, Culver RN, Cvijovic I, D'Amato G, Ezran C, Galdos FX, Gillich A, Goodyer WR, Hang Y, Hayashi A, Houshdaran S, Huang X, Irwin JC, Jang S, Juanico JV, Kershner AM, Kim S, Kiss B, Kolluru S, Kong W, Kumar ME, Kuo AH, Leylek R, Li B, Loeb GB, Lu WJ, Mantri S, Markovic M, McAlpine PL, de Morree A, Morri M, Mrouj K, Mukherjee S, Muser T, Neuhöfer P, Nguyen TD, Perez K, Phansalkar R, Pisco AO, Puluca N, Qi Z, Rao P, Raquer-McKay H, Schaum N, Scott B, Seddighzadeh B, Segal J, Sen S, Sikandar S, Spencer SP, Steffes LC, Subramaniam VR, Swarup A, Swift M, Travaglini KJ, Van Treuren W, Trimm E, Veizades S, Vijayakumar S, Vo KC, Vorperian SK, Wang W, Weinstein HNW, Winkler J, Wu TTH, Xie J, Yung AR, Zhang Y, Detweiler AM, Mekonen H, Neff NF, Sit RV, Tan M, Yan J, Bean GR, Charu V, Forgó E, Martin BA, Ozawa MG, Silva O, Tan SY, Toland A, Vemuri VNP, Afik S, Awayan K, Botvinnik OB, Byrne A, Chen M, Dehghannasiri R, Detweiler AM, Gayoso A, Granados AA, Li Q, Mahmoudabadi G, McGeever A, de Morree A, Olivieri JE, Park M, Pisco AO, Ravikumar N, Salzman J, Stanley G, Swift M, Tan M, Tan W, Tarashansky AJ, Vanheusden R, Vorperian SK, Wang P, Wang S, Xing G, Xu C, Yosef N, Alcántara-Hernández M, Antony J, Chan CKF, Chang CA, Colville A, Crasta S, Culver R, Dethlefsen L, Ezran C, Gillich A, Hang Y, Ho PY, Irwin JC, Jang S, Kershner AM, Kong W, Kumar ME, Kuo AH, Leylek R, Liu S, Loeb GB, Lu WJ, Maltzman JS, Metzger RJ, de Morree A, Neuhöfer P, Perez K, Phansalkar R, Qi Z, Rao P, Raquer-McKay H, Sasagawa K, Scott B, Sinha R, Song H, Spencer SP, Swarup A, Swift M, Travaglini KJ, Trimm E, Veizades S, Vijayakumar S, Wang B, Wang W, Winkler J, Xie J, Yung AR, Artandi SE, Beachy PA, Clarke MF, Giudice LC, Huang FW, Huang KC, Idoyaga J, Kim SK, Krasnow M, Kuo CS, Nguyen P, Quake SR, Rando TA, Red-Horse K, Reiter J, Relman DA, Sonnenburg JL, Wang B, Wu A, Wu SM, Wyss-Coray T

Endoderm development requires centrioles to restrain p53-mediated apoptosis in the absence of ERK activity.

Developmental cell

Xie C, Abrams SR, Herranz-Pérez V, García-Verdugo JM, Reiter JF

ATXN10 Is Required for Embryonic Heart Development and Maintenance of Epithelial Cell Phenotypes in the Adult Kidney and Pancreas.

Frontiers in cell and developmental biology

Bentley-Ford MR, Andersen RS, Croyle MJ, Haycraft CJ, Clearman KR, Foote JB, Reiter JF, Yoder BK

Ciliary Hedgehog signaling patterns the digestive system to generate mechanical forces driving elongation.

Nature communications

Yang Y, Paivinen P, Xie C, Krup AL, Makela TP, Mostov KE, Reiter JF

A ciliopathy complex builds distal appendages to initiate ciliogenesis.

The Journal of cell biology

Kumar D, Rains A, Herranz-Pérez V, Lu Q, Shi X, Swaney DL, Stevenson E, Krogan NJ, Huang B, Westlake C, Garcia-Verdugo JM, Yoder BK, Reiter JF

Label-retention expansion microscopy.

The Journal of cell biology

Shi X, Li Q, Dai Z, Tran AA, Feng S, Ramirez AD, Lin Z, Wang X, Chow TT, Chen J, Kumar D, McColloch AR, Reiter JF, Huang EJ, Seiple IB, Huang B

Melanocortin 4 receptor signals at the neuronal primary cilium to control food intake and body weight.

The Journal of clinical investigation

Wang Y, Bernard A, Comblain F, Yue X, Paillart C, Zhang S, Reiter JF, Vaisse C

Vertebrate cells differentially interpret ciliary and extraciliary cAMP.

Cell

Truong ME, Bilekova S, Choksi SP, Li W, Bugaj LJ, Xu K, Reiter JF

Smoothened-activating lipids drive resistance to CDK4/6 inhibition in Hedgehog-associated medulloblastoma cells and preclinical models.

The Journal of clinical investigation

Daggubati V, Hochstelter J, Bommireddy A, Choudhury A, Krup AL, Kaur P, Tong P, Li A, Xu L, Reiter JF, Raleigh DR

Sterol and oxysterol synthases near the ciliary base activate the Hedgehog pathway.

The Journal of cell biology

Findakly S, Daggubati V, Garcia G, LaStella SA, Choudhury A, Tran C, Li A, Tong P, Garcia JQ, Puri N, Reiter JF, Xu L, Raleigh DR

A transient role of the ciliary gene Inpp5e in controlling direct versus indirect neurogenesis in cortical development.

eLife

Hasenpusch-Theil K, Laclef C, Colligan M, Fitzgerald E, Howe K, Carroll E, Abrams SR, Reiter JF, Schneider-Maunoury S, Theil T

Omega-3 Fatty Acids Activate Ciliary FFAR4 to Control Adipogenesis.

Cell

Hilgendorf KI, Johnson CT, Mezger A, Rice SL, Norris AM, Demeter J, Greenleaf WJ, Reiter JF, Kopinke D, Jackson PK

Dynamic Remodeling of Membrane Composition Drives Cell Cycle through Primary Cilia Excision.

Cell

Phua SC, Chiba S, Suzuki M, Su E, Roberson EC, Pusapati GV, Schurmans S, Setou M, Rohatgi R, Reiter JF, Ikegami K, Inoue T

SFI1 promotes centriole duplication by recruiting USP9X to stabilize the microcephaly protein STIL.

The Journal of cell biology

Kodani A, Moyer T, Chen A, Holland A, Walsh CA, Reiter JF

Hedgehog Pathway Activation Alters Ciliary Signaling in Primary Hypothalamic Cultures.

Frontiers in cellular neuroscience

Bansal R, Engle SE, Antonellis PJ, Whitehouse LS, Baucum AJ, Cummins TR, Reiter JF, Berbari NF

Deformed alignment of super-resolution images for semi-flexible structures.

PloS one

Shi X, Garcia G, Wang Y, Reiter JF, Huang B

Misactivation of Hedgehog signaling causes inherited and sporadic cancers.

The Journal of clinical investigation

Raleigh DR, Reiter JF

Cilia-Associated Oxysterols Activate Smoothened.

Molecular cell

Raleigh DR, Sever N, Choksi PK, Sigg MA, Hines KM, Thompson BM, Elnatan D, Jaishankar P, Bisignano P, Garcia-Gonzalo FR, Krup AL, Eberl M, Byrne EFX, Siebold C, Wong SY, Renslo AR, Grabe M, McDonald JG, Xu L, Beachy PA, Reiter JF

Brain Somatic Mutations in MTOR Disrupt Neuronal Ciliogenesis, Leading to Focal Cortical Dyslamination.

Neuron

Park SM, Lim JS, Ramakrishina S, Kim SH, Kim WK, Lee J, Kang HC, Reiter JF, Kim DS, Kim HH, Lee JH

How the Ciliary Membrane Is Organized Inside-Out to Communicate Outside-In.

Current biology : CB

Garcia G, Raleigh DR, Reiter JF

Subcellular localization of MC4R with ADCY3 at neuronal primary cilia underlies a common pathway for genetic predisposition to obesity.

Nature genetics

Siljee JE, Wang Y, Bernard AA, Ersoy BA, Zhang S, Marley A, Von Zastrow M, Reiter JF, Vaisse C

Evolutionary Proteomics Uncovers Ancient Associations of Cilia with Signaling Pathways.

Developmental cell

Sigg MA, Menchen T, Lee C, Johnson J, Jungnickel MK, Choksi SP, Garcia G, Busengdal H, Dougherty GW, Pennekamp P, Werner C, Rentzsch F, Florman HM, Krogan N, Wallingford JB, Omran H, Reiter JF

Hedgehog signaling drives medulloblastoma growth via CDK6.

The Journal of clinical investigation

Raleigh DR, Choksi PK, Krup AL, Mayer W, Santos N, Reiter JF

Erratum: Super-resolution microscopy reveals that disruption of ciliary transition-zone architecture causes Joubert syndrome.

Nature cell biology

Shi X, Garcia G, Van De Weghe JC, McGorty R, Pazour GJ, Doherty D, Huang B, Reiter JF

Super-resolution microscopy reveals that disruption of ciliary transition-zone architecture causes Joubert syndrome.

Nature cell biology

Shi X, Garcia G, Van De Weghe JC, McGorty R, Pazour GJ, Doherty D, Huang B, Reiter JF

Genes and molecular pathways underpinning ciliopathies.

Nature reviews. Molecular cell biology

Reiter JF, Leroux MR

Cilia and Obesity.

Cold Spring Harbor perspectives in biology

Vaisse C, Reiter JF, Berbari NF

Open Sesame: How Transition Fibers and the Transition Zone Control Ciliary Composition.

Cold Spring Harbor perspectives in biology

Garcia-Gonzalo FR, Reiter JF

Dynamic Remodeling of Membrane Composition Drives Cell Cycle through Primary Cilia Excision.

Cell

Phua SC, Chiba S, Suzuki M, Su E, Roberson EC, Pusapati GV, Schurmans S, Setou M, Rohatgi R, Reiter JF, Ikegami K, Inoue T

Microcephaly Proteins Wdr62 and Aspm Define a Mother Centriole Complex Regulating Centriole Biogenesis, Apical Complex, and Cell Fate.

Neuron

Jayaraman D, Kodani A, Gonzalez DM, Mancias JD, Mochida GH, Vagnoni C, Johnson J, Krogan N, Harper JW, Reiter JF, Yu TW, Bae BI, Walsh CA

Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex.

Cell

Zhang X, Chen MH, Wu X, Kodani A, Fan J, Doan R, Ozawa M, Ma J, Yoshida N, Reiter JF, Black DL, Kharchenko PV, Sharp PA, Walsh CA

A primer on the mouse basal body.

Cilia

Garcia G, Reiter JF

MKS5 and CEP290 Dependent Assembly Pathway of the Ciliary Transition Zone.

PLoS biology

Li C, Jensen VL, Park K, Kennedy J, Garcia-Gonzalo FR, Romani M, De Mori R, Bruel AL, Gaillard D, Doray B, Lopez E, Rivière JB, Faivre L, Thauvin-Robinet C, Reiter JF, Blacque OE, Valente EM, Leroux MR

Endothelial primary cilia inhibit atherosclerosis.

EMBO reports

Dinsmore C, Reiter JF

Conserved Genetic Interactions between Ciliopathy Complexes Cooperatively Support Ciliogenesis and Ciliary Signaling.

PLoS genetics

Yee LE, Garcia-Gonzalo FR, Bowie RV, Li C, Kennedy JK, Ashrafi K, Blacque OE, Leroux MR, Reiter JF

Phosphoinositides Regulate Ciliary Protein Trafficking to Modulate Hedgehog Signaling.

Developmental cell

Garcia-Gonzalo FR, Phua SC, Roberson EC, Garcia G, Abedin M, Schurmans S, Inoue T, Reiter JF

Centriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplication.

eLife

Kodani A, Yu TW, Johnson JR, Jayaraman D, Johnson TL, Al-Gazali L, Sztriha L, Partlow JN, Kim H, Krup AL, Dammermann A, Krogan NJ, Walsh CA, Reiter JF

TMEM231, mutated in orofaciodigital and Meckel syndromes, organizes the ciliary transition zone.

The Journal of cell biology

Roberson EC, Dowdle WE, Ozanturk A, Garcia-Gonzalo FR, Li C, Halbritter J, Elkhartoufi N, Porath JD, Cope H, Ashley-Koch A, Gregory S, Thomas S, Sayer JA, Saunier S, Otto EA, Katsanis N, Davis EE, Attié-Bitach T, Hildebrandt F, Leroux MR, Reiter JF

Ciliary vesicle formation: a prelude to ciliogenesis.

Developmental cell

Yee LE, Reiter JF

Katanin p80 regulates human cortical development by limiting centriole and cilia number.

Neuron

Hu WF, Pomp O, Ben-Omran T, Kodani A, Henke K, Mochida GH, Yu TW, Woodworth MB, Bonnard C, Raj GS, Tan TT, Hamamy H, Masri A, Shboul M, Al Saffar M, Partlow JN, Al-Dosari M, Alazami A, Alowain M, Alkuraya FS, Reiter JF, Harris MP, Reversade B, Walsh CA

C2cd3 is critical for centriolar distal appendage assembly and ciliary vesicle docking in mammals.

Proceedings of the National Academy of Sciences of the United States of America

Ye X, Zeng H, Ning G, Reiter JF, Liu A

Hedgehog signaling controls T cell killing at the immunological synapse.

Science (New York, N.Y.)

de la Roche M, Ritter AT, Angus KL, Dinsmore C, Earnshaw CH, Reiter JF, Griffiths GM

Keratin 79 identifies a novel population of migratory epithelial cells that initiates hair canal morphogenesis and regeneration.

Development (Cambridge, England)

Veniaminova NA, Vagnozzi AN, Kopinke D, Do TT, Murtaugh LC, Maillard I, Dlugosz AA, Reiter JF, Wong SY

Thyroid-specific inactivation of KIF3A alters the TSH signaling pathway and leads to hypothyroidism.

Journal of molecular endocrinology

D'Amico E, Gayral S, Massart C, Van Sande J, Reiter JF, Dumont JE, Robaye B, Schurmans S

Kif3a interacts with Dynactin subunit p150 Glued to organize centriole subdistal appendages.

The EMBO journal

Kodani A, Salomé Sirerol-Piquer M, Seol A, Garcia-Verdugo JM, Reiter JF

Small molecule inhibitors of Smoothened ciliary localization and ciliogenesis.

Proceedings of the National Academy of Sciences of the United States of America

Wu VM, Chen SC, Arkin MR, Reiter JF

Scoring a backstage pass: mechanisms of ciliogenesis and ciliary access.

The Journal of cell biology

Garcia-Gonzalo FR, Reiter JF

A high-fat diet regulates gastrin and acid secretion through primary cilia.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Saqui-Salces M, Dowdle WE, Reiter JF, Merchant JL

Polycomb-like 3 promotes polycomb repressive complex 2 binding to CpG islands and embryonic stem cell self-renewal.

PLoS genetics

Hunkapiller J, Shen Y, Diaz A, Cagney G, McCleary D, Ramalho-Santos M, Krogan N, Ren B, Song JS, Reiter JF

Disruption of a ciliary B9 protein complex causes Meckel syndrome.

American journal of human genetics

Dowdle WE, Robinson JF, Kneist A, Sirerol-Piquer MS, Frints SG, Corbit KC, Zaghloul NA, Zaghloul NA, van Lijnschoten G, Mulders L, Verver DE, Zerres K, Reed RR, Attié-Bitach T, Johnson CA, García-Verdugo JM, Katsanis N, Bergmann C, Reiter JF

A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition.

Nature genetics

Garcia-Gonzalo FR, Corbit KC, Sirerol-Piquer MS, Ramaswami G, Otto EA, Noriega TR, Seol AD, Robinson JF, Bennett CL, Josifova DJ, García-Verdugo JM, Katsanis N, Hildebrandt F, Reiter JF

Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.

Cell

Sang L, Miller JJ, Corbit KC, Giles RH, Brauer MJ, Otto EA, Baye LM, Wen X, Scales SJ, Kwong M, Huntzicker EG, Sfakianos MK, Sandoval W, Bazan JF, Kulkarni P, Garcia-Gonzalo FR, Seol AD, O'Toole JF, Held S, Reutter HM, Lane WS, Rafiq MA, Noor A, Ansar M, Devi AR, Sheffield VC, Slusarski DC, Vincent JB, Doherty DA, Hildebrandt F, Reiter JF, Jackson PK

Role of epidermal primary cilia in the homeostasis of skin and hair follicles.

Development (Cambridge, England)

Croyle MJ, Lehman JM, O'Connor AK, Wong SY, Malarkey EB, Iribarne D, Dowdle WE, Schoeb TR, Verney ZM, Athar M, Michaud EJ, Reiter JF, Yoder BK

Wounding mobilizes hair follicle stem cells to form tumors.

Proceedings of the National Academy of Sciences of the United States of America

Wong SY, Reiter JF

Crippling SWI-SNF makes tumors GLI-ful.

Nature medicine

Reiter JF

Vive la science! Vive le hérisson!

EMBO reports

Reiter JF, de Sauvage FJ

Ofd1, a human disease gene, regulates the length and distal structure of centrioles.

Developmental cell

Singla V, Romaguera-Ros M, Garcia-Verdugo JM, Reiter JF

Polycomb-like 2 associates with PRC2 and regulates transcriptional networks during mouse embryonic stem cell self-renewal and differentiation.

Cell stem cell

Walker E, Chang WY, Hunkapiller J, Cagney G, Garcha K, Torchia J, Krogan NJ, Reiter JF, Stanford WL

Floxin, a resource for genetically engineering mouse ESCs.

Nature methods

Singla V, Hunkapiller J, Santos N, Seol AD, Norman AR, Wakenight P, Skarnes WC, Reiter JF

Primary cilia can both mediate and suppress Hedgehog pathway-dependent tumorigenesis.

Nature medicine

Wong SY, Seol AD, So PL, Ermilov AN, Bichakjian CK, Epstein EH, Dlugosz AA, Reiter JF

The extracellular domain of Smoothened regulates ciliary localization and is required for high-level Hh signaling.

Current biology : CB

Aanstad P, Santos N, Corbit KC, Scherz PJ, Trinh le A, Salvenmoser W, Huisken J, Reiter JF, Stainier DY

Building it up and taking it down: the regulation of vertebrate ciliogenesis.

Developmental dynamics : an official publication of the American Association of Anatomists

Santos N, Reiter JF

The primary cilium at the crossroads of mammalian hedgehog signaling.

Current topics in developmental biology

Wong SY, Reiter JF

Kif3a constrains beta-catenin-dependent Wnt signalling through dual ciliary and non-ciliary mechanisms.

Nature cell biology

Corbit KC, Shyer AE, Dowdle WE, Gaulden J, Singla V, Chen MH, Chuang PT, Reiter JF

Vesicle transport, cilium formation, and membrane specialization: the origins of a sensory organelle.

Proceedings of the National Academy of Sciences of the United States of America

Reiter JF, Mostov K

Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli.

Developmental biology

May SR, Ashique AM, Karlen M, Wang B, Shen Y, Zarbalis K, Reiter J, Ericson J, Peterson AS

Vertebrate Smoothened functions at the primary cilium.

Nature

Corbit KC, Aanstad P, Singla V, Norman AR, Stainier DY, Reiter JF

Notch signaling can regulate endoderm formation in zebrafish.

Developmental dynamics : an official publication of the American Association of Anatomists

Kikuchi Y, Verkade H, Reiter JF, Kim CH, Chitnis AB, Kuroiwa A, Stainier DY

Multiple roles for Gata5 in zebrafish endoderm formation.

Development (Cambridge, England)

Reiter JF, Kikuchi Y, Stainier DY

Gata5 is required for the development of the heart and endoderm in zebrafish.

Genes & development

Reiter JF, Alexander J, Rodaway A, Yelon D, Patient R, Holder N, Stainier DY

Research Area: 
Central Regulation
Human Genetics