Susan Noworolski, PhD

ADJUNCT PROF-GENCOMP-B
Radiology
+1 415 353-9409

Dr. Noworolski is a Professor of Radiology and Biomedical Imaging and of the Graduate Group in Bioengineering. She is Director of Graduate Studies for the Masters of Science in Biomedical Imaging (MSBI) program at UCSF. Dr. Noworolski’s research focuses on developing magnetic resonance imaging techniques and quantitative analyses to enable robust interpretation of MR measures to characterize the anatomy, physiology, and pathology studied. She has been focused primarily on studying prostate cancer and metabolic health.

In the prostate cancer area, she has characterized MR signatures of the heterogeneous benign and cancerous tissues of the prostate through correlation of multiparametric MR imaging measures with histopathology of the prostate and has developed quantitative, multiparametric models to generate risk maps of cancer and of aggressive cancer in the prostate. She is currently leveraging these findings to facilitate characterizing the risk for men considering active surveillance of their prostate cancer. Her lab has been automating our tools and transitioning some of our analyses from traditional machine learning approaches to deep learning approaches when appropriate. Through this research, we are initiating translating these resources so they can be used clinically.

In the metabolic health area, she has extended earlier research covering diagnostic evaluation of fat, inflammation and fibrosis in the liver to characterize disease in individuals with HIV and hepatitis C infection and to assess interventions. With collaborators, she has demonstrated effects of short-term dietary changes on de novo lipogenesis and lipid storage in the livers of normal subjects and subjects, including children, with obesity and/or metabolic syndrome. Through traditional image processing and via convolutional neural network algorithms, her lab has automated the analyses of some of our more established metrics of fatty liver disease. Her lab is pursuing novel imaging techniques to aid in characterizing the effects of sleep apnea on mitochondrial function, in addition to other metabolic syndrome effects, and is studying the role of MR to characterize ectopic fat and fibrosis and their roles in metabolic health and as predictors of Type II diabetes.

Publications: 

HIV, HIV-specific Factors and Myocardial Disease in Women.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Kato Y, Ambale-Venkatesh B, Naveed M, Shitole SG, Peng Q, Levsky JM, Haramati LB, Ordovas K, Noworolski SM, Lee YJ, Kim RS, Lazar JM, Anastos K, Tien PC, Kaplan RC, Lima JAC, Kizer JR

Controlled attenuation parameter accurately detects liver steatosis in people with HIV.

AIDS (London, England)

Duarte M, Tien P, Ma Y, Noworolski SM, Korn N, Price JC

Effects of Isocaloric Fructose Restriction on Ceramide Levels in Children with Obesity and Cardiometabolic Risk: Relation to Hepatic De Novo Lipogenesis and Insulin Sensitivity.

Nutrients

Olson E, Suh JH, Schwarz JM, Noworolski SM, Jones GM, Barber JR, Erkin-Cakmak A, Mulligan K, Lustig RH, Mietus-Snyder M

Identification of prostate cancer using multiparametric MR imaging characteristics of prostate tissues referenced to whole mount histopathology.

Magnetic resonance imaging

Gibbons M, Starobinets O, Simko JP, Kurhanewicz J, Carroll PR, Noworolski SM

Abstract 16511: Isocaloric Fructose Restriction Improves Postprandial Chylomicron and VLDL Excursions in Adolescents With Obesity by Reducing Angiopoietin-Like Protein 3 and Apolipoprotein CIII.

Circulation

Yasmin Bains, Ayca Erkin-Cakmak, Russell Caccavello, Kathleen Mulligan, Susan Noworolski, Jean-Marc Schwarz, Robert Lustig, Alejandro Gugliucci

Short-Term Isocaloric Fructose Restriction Improves Postprandial Lipoprotein Subclass Profiles.

Atherosclerosis

A. Gugliucci, Y. Bains, R. Caccavello, M. Wen, A. Erkin-Cakmak, K. Mulligan, R. Lustig, S. Noworolski, J.M. Schwarz

Isocaloric Fructose Restriction Reduces Serum d-Lactate Concentration in Children With Obesity and Metabolic Syndrome.

The Journal of clinical endocrinology and metabolism

Erkin-Cakmak A, Bains Y, Caccavello R, Noworolski SM, Schwarz JM, Mulligan K, Lustig RH, Gugliucci A

Quantitative imaging biomarkers alliance (QIBA) recommendations for improved precision of DWI and DCE-MRI derived biomarkers in multicenter oncology trials.

Journal of Magnetic Resonance Imaging

Amita Shukla-Dave, Nancy A. Obuchowski, Thomas L. Chenevert, Sachin Jambawalikar, Lawrence H. Schwartz, Dariya Malyarenko, Wei Huang, Susan M. Noworolski, Robert J. Young, Mark S. Shiroishi, Harrison Kim, Catherine Coolens, Hendrik Laue, Caroline Chung, Mark Rosen, Michael Boss, Edward F. Jackson

Phase I Study of CTT1057, an 18F-Labeled Imaging Agent with Phosphoramidate Core Targeting Prostate-Specific Membrane Antigen in Prostate Cancer.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Behr SC, Aggarwal R, VanBrocklin HF, Flavell RR, Gao K, Small EJ, Blecha J, Jivan S, Hope TA, Simko JP, Kurhanewicz J, Noworolski SM, Korn NJ, De Los Santos R, Cooperberg MR, Carroll PR, Nguyen HG, Greene KL, Langton-Webster B, Berkman CE, Seo Y

Quantitative imaging biomarkers alliance (QIBA) recommendations for improved precision of DWI and DCE-MRI derived biomarkers in multicenter oncology trials.

Journal of magnetic resonance imaging : JMRI

Shukla-Dave A, Obuchowski NA, Chenevert TL, Jambawalikar S, Schwartz LH, Malyarenko D, Huang W, Noworolski SM, Young RJ, Shiroishi MS, Kim H, Coolens C, Laue H, Chung C, Rosen M, Boss M, Jackson EF

Assessing high-intensity focused ultrasound treatment of prostate cancer with hyperpolarized 13 C dual-agent imaging of metabolism and perfusion.

NMR in biomedicine

Lee JE, Diederich CJ, Bok R, Sriram R, Santos RD, Noworolski SM, Salgaonkar VA, Adams MS, Vigneron DB, Kurhanewicz J

Phase I study of dose escalation to dominant intraprostatic lesions using high-dose-rate brachytherapy.

Journal of contemporary brachytherapy

Chapman CH, Braunstein SE, Pouliot J, Noworolski SM, Weinberg V, Cunha A, Kurhanewicz J, Gottschalk AR, Roach MI, Hsu IC

Characterization and stratification of prostate lesions based on comprehensive multiparametric MRI using detailed whole-mount histopathology as a reference standard.

NMR in biomedicine

Starobinets O, Simko JP, Kuchinsky K, Kornak J, Carroll PR, Greene KL, Kurhanewicz J, Noworolski SM

Controlled attenuation parameter and magnetic resonance spectroscopy-measured liver steatosis are discordant in obese HIV-infected adults.

AIDS (London, England)

Price JC, Dodge JL, Ma Y, Scherzer R, Korn N, Tillinghast K, Peters MG, Noworolski S, Tien PC

Effects of Dietary Fructose Restriction on Liver Fat, De Novo Lipogenesis, and Insulin Kinetics in Children With Obesity.

Gastroenterology

Schwarz JM, Noworolski SM, Erkin-Cakmak A, Korn NJ, Wen MJ, Tai VW, Jones GM, Palii SP, Velasco-Alin M, Pan K, Patterson BW, Gugliucci A, Lustig RH, Mulligan K

Human immunodeficiency virus-infected and uninfected adults with non-genotype 3 hepatitis C virus have less hepatic steatosis than adults with neither infection.

Hepatology (Baltimore, Md.)

Price JC, Ma Y, Scherzer R, Korn N, Tillinghast K, Peters MG, Noworolski SM, Tien PC

Sex differences in the association of HIV infection with hepatic steatosis.

AIDS (London, England)

Kardashian A, Ma Y, Scherzer R, Price JC, Sarkar M, Korn N, Tillinghast K, Peters MG, Noworolski SM, Tien PC

Short-term isocaloric fructose restriction lowers apoC-III levels and yields less atherogenic lipoprotein profiles in children with obesity and metabolic syndrome.

Atherosclerosis

Gugliucci A, Lustig RH, Caccavello R, Erkin-Cakmak A, Noworolski SM, Tai VW, Wen MJ, Mulligan K, Schwarz JM

Practical aspects of prostate MRI: hardware and software considerations, protocols, and patient preparation.

Abdominal radiology (New York)

Starobinets O, Korn N, Iqbal S, Noworolski SM, Zagoria R, Kurhanewicz J, Westphalen AC

Isocaloric fructose restriction and metabolic improvement in children with obesity and metabolic syndrome.

Obesity (Silver Spring, Md.)

Lustig RH, Mulligan K, Noworolski SM, Tai VW, Wen MJ, Erkin-Cakmak A, Gugliucci A, Schwarz JM

High-Resolution 3-T Endorectal Prostate MRI: A Multireader Study of Radiologist Preference and Perceived Interpretive Quality of 2D and 3D T2-Weighted Fast Spin-Echo MR Images.

AJR. American journal of roentgenology

Westphalen AC, Noworolski SM, Harisinghani M, Jhaveri KS, Raman SS, Rosenkrantz AB, Wang ZJ, Zagoria RJ, Kurhanewicz J

Effect of a High-Fructose Weight-Maintaining Diet on Lipogenesis and Liver Fat.

The Journal of clinical endocrinology and metabolism

Schwarz JM, Noworolski SM, Wen MJ, Dyachenko A, Prior JL, Weinberg ME, Herraiz LA, Tai VW, Bergeron N, Bersot TP, Rao MN, Schambelan M, Mulligan K

Reduced-FOV excitation decreases susceptibility artifact in diffusion-weighted MRI with endorectal coil for prostate cancer detection.

Magnetic resonance imaging

Korn N, Kurhanewicz J, Banerjee S, Starobinets O, Saritas E, Noworolski S

Bone structure and perfusion quantification of bone marrow edema pattern in the wrist of patients with rheumatoid arthritis: a multimodality study.

The Journal of rheumatology

Teruel JR, Burghardt AJ, Rivoire J, Srikhum W, Noworolski SM, Link TM, Imboden JB, Li X

A Randomized Controlled Trial of a Mindfulness-Based Intervention for Metabolic Health in Obese Adults.

Journal of Alternative and Complementary Medicine

Jennifer Daubenmier, Elissa Epel, Patricia Moran, Jean Kristeller, Michael Acree, Peter Bacchetti, Margaret Kemeny, Mary Dallman, Robert Lustig, Carl Grunfeld, Douglas Nixon, Jeffery Milush, Veronica Goldman, Michaela Kiernan, Susan Noworolski, Barbara Laraia, Frederick Hecht

Role of endorectal MR imaging and MR spectroscopic imaging in defining treatable intraprostatic tumor foci in prostate cancer: quantitative analysis of imaging contour compared to whole-mount histopathology.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

Anwar M, Westphalen AC, Jung AJ, Noworolski SM, Simko JP, Kurhanewicz J, Roach M, Carroll PR, Coakley FV

Semiautomatic registration of digital histopathology images to in vivo MR images in molded and unmolded prostates.

Journal of magnetic resonance imaging : JMRI

Starobinets O, Guo R, Simko JP, Kuchinsky K, Kurhanewicz J, Carroll PR, Greene KL, Noworolski SM

Role of Endorectal MRI and MRSI in Defining the Dominant Intraprostatic Lesion in Prostate Cancer: Quantitative Analysis of Imaging Contour Compared to Whole-Mount Histopathology.

International Journal of Radiation Oncology • Biology • Physics

M.M. Anwar, A.C. Westphalen, A. Jung, S. Noworolski, J. Kurhanewicz, J.P. Simko, P.R. Carroll, F.V. Coakley

Liver steatosis: concordance of MR imaging and MR spectroscopic data with histologic grade.

Radiology

Noworolski SM, Lam MM, Merriman RB, Ferrell L, Qayyum A

MRI steatosis grading: development and initial validation of a color mapping system.

AJR. American journal of roentgenology

Qayyum A, Nystrom M, Noworolski SM, Chu P, Mohanty A, Merriman R

Liver diffusivity in healthy volunteers and patients with chronic liver disease: comparison of breathhold and free-breathing techniques.

Journal of magnetic resonance imaging : JMRI

Eatesam M, Noworolski SM, Tien PC, Nystrom M, Dodge JL, Merriman RB, Qayyum A

Quantitative characterization of bone marrow edema pattern in rheumatoid arthritis using 3 Tesla MRI.

Journal of magnetic resonance imaging : JMRI

Li X, Yu A, Virayavanich W, Noworolski SM, Link TM, Imboden J

Interactive, multi-modality image registrations for combined MRI/MRSI-planned HDR prostate brachytherapy.

Journal of contemporary brachytherapy

Reed G, Cunha JA, Noworolski S, Kurhanewicz J, Vigneron D, Hsu IC, Pouliot J

Adipose tissue and metabolic factors associated with steatosis in HIV/HCV coinfection: histology versus magnetic resonance spectroscopy.

Journal of acquired immune deficiency syndromes (1999)

Ghotb A, Noworolski SM, Madden E, Scherzer R, Qayyum A, Pannell J, Ferrell L, Peters M, Tien PC

Post-processing correction of the endorectal coil reception effects in MR spectroscopic imaging of the prostate.

Journal of magnetic resonance imaging : JMRI

Noworolski SM, Reed GD, Kurhanewicz J, Vigneron DB

Magnetic resonance imaging for secondary assessment of breast density in a high-risk cohort.

Magnetic resonance imaging

Klifa C, Carballido-Gamio J, Wilmes L, Laprie A, Shepherd J, Gibbs J, Fan B, Noworolski S, Hylton N

Respiratory motion-corrected proton magnetic resonance spectroscopy of the liver.

Magnetic resonance imaging

Noworolski SM, Tien PC, Merriman R, Vigneron DB, Qayyum A

Liver steatosis: investigation of opposed-phase T1-weighted liver MR signal intensity loss and visceral fat measurement as biomarkers.

Radiology

Bahl M, Qayyum A, Westphalen AC, Noworolski SM, Chu PW, Ferrell L, Tien PC, Bass NM, Merriman RB

Dynamic contrast-enhanced MRI and MR diffusion imaging to distinguish between glandular and stromal prostatic tissues.

Magnetic resonance imaging

Noworolski SM, Vigneron DB, Chen AP, Kurhanewicz J

A clinical comparison of rigid and inflatable endorectal-coil probes for MRI and 3D MR spectroscopic imaging (MRSI) of the prostate.

Journal of magnetic resonance imaging : JMRI

Noworolski SM, Crane JC, Vigneron DB, Kurhanewicz J

Class solution in inverse planned HDR prostate brachytherapy for dose escalation of DIL defined by combined MRI/MRSI.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

Kim Y, Hsu IC, Lessard E, Kurhanewicz J, Noworolski SM, Pouliot J

Magnetic Resonance Spectroscopy and Spectroscopic Imaging of the Prostate, Breast, and Liver.

Modern Magnetic Resonance

Mark G. Swanson, Susan M. Noworolski, John Kurhanewicz

Dynamic Contrast-Enhanced MRI in Normal and Abnormal Prostate Tissues as Defined by Biopsy, MRI, and 3D MRSI.

The Journal of urology

S.M. Noworolski, R.G. Henry, D.B. Vigneron, J. Kurhanewicz

Registration of MR prostate images with biomechanical modeling and nonlinear parameter estimation.

Medical physics

Alterovitz R, Goldberg K, Pouliot J, Hsu IC, Kim Y, Noworolski SM, Kurhanewicz J

Expandable and rigid endorectal coils for prostate MRI: impact on prostate distortion and rigid image registration.

Medical physics

Kim Y, Hsu IC, Pouliot J, Noworolski SM, Vigneron DB, Kurhanewicz J

Dynamic contrast-enhanced MRI in normal and abnormal prostate tissues as defined by biopsy, MRI, and 3D MRSI.

Magnetic resonance in medicine

Noworolski SM, Henry RG, Vigneron DB, Kurhanewicz J

Challenges in dynamic contrast-enhanced MRI imaging of cervical lymph nodes to detect metastatic disease.

Journal of magnetic resonance imaging : JMRI

Noworolski SM, Fischbein NJ, Kaplan MJ, Lu Y, Nelson SJ, Carvajal L, Henry RG

Assessment of metastatic cervical adenopathy using dynamic contrast-enhanced MR imaging.

AJNR. American journal of neuroradiology

Fischbein NJ, Noworolski SM, Henry RG, Kaplan MJ, Dillon WP, Nelson SJ

Three-dimensional proton MR spectroscopic imaging of premature and term neonates.

AJNR. American journal of neuroradiology

Vigneron DB, Barkovich AJ, Noworolski SM, von dem Bussche M, Henry RG, Lu Y, Partridge JC, Gregory G, Ferriero DM

Time-dependent effects of hormone-deprivation therapy on prostate metabolism as detected by combined magnetic resonance imaging and 3D magnetic resonance spectroscopic imaging.

Magnetic resonance in medicine

Mueller-Lisse UG, Swanson MG, Vigneron DB, Hricak H, Bessette A, Males RG, Wood PJ, Noworolski S, Nelson SJ, Barken I, Carroll PR, Kurhanewicz J

Preoperative proton MR spectroscopic imaging of brain tumors: correlation with histopathologic analysis of resection specimens.

AJNR. American journal of neuroradiology

Dowling C, Bollen AW, Noworolski SM, McDermott MW, Barbaro NM, Day MR, Henry RG, Chang SM, Dillon WP, Nelson SJ, Vigneron DB

An automated technique for the quantitative assessment of 3D-MRSI data from patients with glioma.

Journal of magnetic resonance imaging : JMRI

McKnight TR, Noworolski SM, Vigneron DB, Nelson SJ

Three-dimensional magnetic resonance spectroscopic imaging of histologically confirmed brain tumors.

Magnetic resonance imaging

Vigneron D, Bollen A, McDermott M, Wald L, Day M, Moyher-Noworolski S, Henry R, Chang S, Berger M, Dillon W, Nelson S

Comparison of relative cerebral blood volume and proton spectroscopy in patients with treated gliomas.

AJNR. American journal of neuroradiology

Henry RG, Vigneron DB, Fischbein NJ, Grant PE, Day MR, Noworolski SM, Star-Lack JM, Wald LL, Dillon WP, Chang SM, Nelson SJ

High spatial resolution 1H-MRSI and segmented MRI of cortical gray matter and subcortical white matter in three regions of the human brain.

Magnetic resonance in medicine

Noworolski SM, Nelson SJ, Henry RG, Day MR, Wald LL, Star-Lack J, Vigneron DB

Serial proton magnetic resonance spectroscopy imaging of glioblastoma multiforme after brachytherapy.

Journal of neurosurgery

Wald LL, Nelson SJ, Day MR, Noworolski SE, Henry RG, Huhn SL, Chang S, Prados MD, Sneed PK, Larson DA, Wara WM, McDermott M, Dillon WP, Gutin PH, Vigneron DB

High resolution T2-weighted imaging of the human brain using surface coils and an analytical reception profile correction.

Journal of magnetic resonance imaging : JMRI

Moyher SE, Wald LL, Nelson SJ, Hallam D, Dillon WP, Norman D, Vigneron DB

Phased array detectors and an automated intensity-correction algorithm for high-resolution MR imaging of the human brain.

Magnetic resonance in medicine

Wald LL, Carvajal L, Moyher SE, Nelson SJ, Grant PE, Barkovich AJ, Vigneron DB

Proton spectroscopic imaging of the human brain using phased array detectors.

Magnetic resonance in medicine

Wald LL, Moyher SE, Day MR, Nelson SJ, Vigneron DB

Surface coil MR imaging of the human brain with an analytic reception profile correction.

Journal of magnetic resonance imaging : JMRI

Moyher SE, Vigneron DB, Nelson SJ

Research Area: 
Bio-imaging
Clinical Research