Suneil Koliwad, MD, PhD

Associate Director & Enrichment Program Director
+1 415 476-9623

Dr. Suneil Koliwad is an Expert in Diabetes, Obesity, and Metabolism, serving as Chief of the Division of Endocrinology and Metabolism at UCSF Health. His lab, based in the UCSF Diabetes Center, focuses on the intersection of nutrition, inflammation, and metabolic tissue function in the context of normal physiology, and diseases such as obesity, diabetes, fatty liver disease, and in the course of aging. His group strives to link basic mechanisms of metabolic regulation to causality in important clinical contexts, and has developed a highly innovative and deeply curated multiethnic obesity cohort at UCSF to assist in achieving this goal.


Novel Automated Self-adjusting Subcutaneous Insulin Algorithm Improves Glycemic Control and Physician Efficiency in Hospitalized Patients.

Journal of diabetes science and technology

Mehta PB, Kohn MA, Rov-Ikpah E, San Luis C, Johnson C, Lee G, Koliwad S, Rushakoff RJ

PTP1B mediates the inhibitory effect of MFGE8 on insulin signaling through the β5 integrin.

The Journal of biological chemistry

Datta R, Mukherjee D, Podolsky MJ, Yang CD, Alba DL, Singh S, Arnold TD, Koliwad S, Lizama CO, Atabai K

Second-Line Pharmaceutical Treatments for Patients with Type 2 Diabetes.

JAMA network open

Vashisht R, Patel A, Dahm L, Han C, Medders KE, Mowers R, Byington CL, Koliwad SK, Butte AJ

Obesity-associated microglial inflammatory activation paradoxically improves glucose tolerance.

Cell metabolism

Douglass JD, Ness KM, Valdearcos M, Wyse-Jackson A, Dorfman MD, Frey JM, Fasnacht RD, Santiago OD, Niraula A, Banerjee J, Robblee M, Koliwad SK, Thaler JP

Twenty-first century management of diabetes with shared telemedicine appointments.

Journal of telemedicine and telecare

Klonoff DC, Yeung AM, Huang J, Espinoza JC, Raymond JK, Lee WA, Koliwad SK, Kerr D

MFGE8 inhibits insulin signaling through PTP1B.

bioRxiv : the preprint server for biology

Datta R, Podolsky MJ, Yang CD, Alba DL, Singh S, Koliwad S, Lizama CO, Atabai K

Obesogens and Obesity: State-of-the-Science and Future Directions Summary from a Healthy Environment and Endocrine Disruptors Strategies Workshop.

The American journal of clinical nutrition

Heindel JJ, Alvarez JA, Atlas E, Cave MC, Chatzi VL, Collier D, Corkey B, Fischer D, Goran MI, Howard S, Kahan S, Kayhoe M, Koliwad S, Kotz CM, La Merrill M, Lobstein T, Lumeng C, Ludwig DS, Lustig RH, Myers P, Nadal A, Trasande L, Redman LM, Rodeheffer MS, Sargis RM, Stephens JM, Ziegler TR, Blumberg B

407 Moving from observational studies to a clinical trial: the impact of obesity and surgical weight loss on breast imaging, tissue, and cancer screening experience: the B-BRITE study.

Journal of clinical and translational science

Elle N Clelland, Judy Gonzalez-Vargas, Sarah G Palilla, Suneil K Koliwad, Heather I Greenwood, Christopher J Schwartz, Chris C. Benz, Diana L Alba, Rita A Mukhtar

The Impact of Insulin Resistance on Loss of Lung Function and Response to Treatment in Asthma.

American journal of respiratory and critical care medicine

Peters MC, Schiebler M, Cardet JC, Johansson MW, Sorkness R, DeBoer MD, Bleecker ER, Meyers DA, Castro M, Sumino K, Erzurum SC, Tattersall MC, Zein JG, Hastie AT, Moore W, Levy BD, Israel E, Duvall M, Phillips BR, Mauger DT, Wenzel SE, Fajt ML, Koliwad SK, Denlinger LC, Woodruff PG, Jarjour NN, Fahy JV, National Heart Lung and Blood Institute Severe Asthma Research Program-3

Excess natural-cause deaths in California by cause and setting: March 2020 through February 2021.

PNAS nexus

Chen YH, Stokes AC, Aschmann HE, Chen R, DeVost S, Kiang MV, Koliwad S, Riley AR, Glymour MM, Bibbins-Domingo K

ASB4 modulates central melanocortinergic neurons and calcitonin signaling to control satiety and glucose homeostasis.

Science signaling

Vagena E, Crneta J, Engström P, He L, Yulyaningsih E, Korpel NL, Cheang RT, Bachor TP, Huang A, Michel G, Attal K, Berrios DI, Valdearcos M, Koliwad SK, Olson DP, Yi CX, Xu AW

Metabolic factors in the regulation of hypothalamic innate immune responses in obesity.

Experimental & molecular medicine

Folick A, Cheang RT, Valdearcos M, Koliwad SK

A Glycemia Risk Index (GRI) of Hypoglycemia and Hyperglycemia for Continuous Glucose Monitoring Validated by Clinician Ratings.

Journal of diabetes science and technology

Klonoff DC, Wang J, Rodbard D, Kohn MA, Li C, Liepmann D, Kerr D, Ahn D, Peters AL, Umpierrez GE, Seley JJ, Xu NY, Nguyen KT, Simonson G, Agus MSD, Al-Sofiani ME, Armaiz-Pena G, Bailey TS, Basu A, Battelino T, Bekele SY, Benhamou PY, Bequette BW, Blevins T, Breton MD, Castle JR, Chase JG, Chen KY, Choudhary P, Clements MA, Close KL, Cook CB, Danne T, Doyle FJ, Drincic A, Dungan KM, Edelman SV, Ejskjaer N, Espinoza JC, Fleming GA, Forlenza GP, Freckmann G, Galindo RJ, Gomez AM, Gutow HA, Heinemann L, Hirsch IB, Hoang TD, Hovorka R, Jendle JH, Ji L, Joshi SR, Joubert M, Koliwad SK, Lal RA, Lansang MC, Lee WA, Leelarathna L, Leiter LA, Lind M, Litchman ML, Mader JK, Mahoney KM, Mankovsky B, Masharani U, Mathioudakis NN, Mayorov A, Messler J, Miller JD, Mohan V, Nichols JH, Nørgaard K, O'Neal DN, Pasquel FJ, Philis-Tsimikas A, Pieber T, Phillip M, Polonsky WH, Pop-Busui R, Rayman G, Rhee EJ, Russell SJ, Shah VN, Sherr JL, Sode K, Spanakis EK, Wake DJ, Waki K, Wallia A, Weinberg ME, Wolpert H, Wright EE, Zilbermint M, Kovatchev B

A gene-diet interaction controlling relative intake of dietary carbohydrates and fats.

Molecular metabolism

Nelson NG, Wu L, Maier MT, Lam D, Cheang R, Alba D, Huang A, Neumann DA, Hill T, Vagena E, Barsh GS, Medina MW, Krauss RM, Koliwad SK, Xu AW

Reducing Methylglyoxal Rescues Obesity Related Phenotypes and Lifespan in a Leptin Receptor Deficient Mouse Model.

Innovation in Aging

Lauren Wimer, Martin Valdearcos Contreras, Muniesh Muthaiyan Shanmugam, Jessica Ramirez, Jennifer Beck, Suneil Koliwad, Pankaj Kapahi

The relationship between physical activity intensity and volume on prospective falls in older adults.

Innovation in Aging

Lauren Wimer, Martin Valdearcos Contreras, Muniesh Muthaiyan Shanmugam, Jessica Ramirez, Jennifer Beck, Suneil Koliwad, Pankaj Kapahi

Probing Insulin Sensitivity with Metabolically Competent Human Stem Cell-Derived White Adipose Tissue Microphysiological Systems.

Small (Weinheim an der Bergstrasse, Germany)

Qi L, Zushin PH, Chang CF, Lee YT, Alba DL, Koliwad SK, Stahl A

The East Asian gut microbiome is distinct from colocalized White subjects and connected to metabolic health.


Ang QY, Alba DL, Upadhyay V, Bisanz JE, Cai J, Lee HL, Barajas E, Wei G, Noecker C, Patterson AD, Koliwad SK, Turnbaugh PJ

Continuous Ketone Monitoring Consensus Report 2021.

Journal of diabetes science and technology

Nguyen KT, Xu NY, Zhang JY, Shang T, Basu A, Bergenstal RM, Castorino K, Chen KY, Kerr D, Koliwad SK, Laffel LM, Mathioudakis N, Midyett LK, Miller JD, Nichols JH, Pasquel FJ, Prahalad P, Prausnitz MR, Seley JJ, Sherr JL, Spanakis EK, Umpierrez GE, Wallia A, Klonoff DC

Microglial Lipid Biology in the Hypothalamic Regulation of Metabolic Homeostasis.

Frontiers in endocrinology

Folick A, Koliwad SK, Valdearcos M

Invariant Natural Killer T cells coordinate removal of senescent cells.

Med (New York, N.Y.)

Arora S, Thompson PJ, Wang Y, Bhattacharyya A, Apostolopoulou H, Hatano R, Naikawadi RP, Shah A, Wolters PJ, Koliwad S, Bhattacharya M, Bhushan A

Autoregulation of insulin receptor signaling through MFGE8 and the αvβ5 integrin.

Proceedings of the National Academy of Sciences of the United States of America

Datta R, Lizama CO, Soltani AK, Mckleroy W, Podolsky MJ, Yang CD, Huynh TL, Cautivo KM, Wang B, Koliwad SK, Abumrad NA, Atabai K

Continuous Ketone Monitoring: A New Paradigm for Physiologic Monitoring.

Journal of diabetes science and technology

Zhang JY, Shang T, Koliwad SK, Klonoff DC

Blocking Kv1.3 potassium channels prevents postoperative neuroinflammation and cognitive decline without impairing wound healing in mice.

British journal of anaesthesia

Lai IK, Valdearcos M, Morioka K, Saxena S, Feng X, Li R, Uchida Y, Lijun A, Li W, Pan J, Koliwad S, Marcucio R, Wulff H, Maze M

CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling.


Oguri Y, Shinoda K, Kim H, Alba DL, Bolus WR, Wang Q, Brown Z, Pradhan RN, Tajima K, Yoneshiro T, Ikeda K, Chen Y, Cheang RT, Tsujino K, Kim CR, Greiner VJ, Datta R, Yang CD, Atabai K, McManus MT, Koliwad SK, Spiegelman BM, Kajimura S

1769-P: Microglial Activation and Inactivation via Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) Alters Peripheral Glucose Homeostasis.



Neuronal modulation of hepatic lipid accumulation induced by bingelike drinking.

American journal of physiology. Endocrinology and metabolism

Ibars M, Maier MT, Yulyaningsih E, Perez L, Cheang R, Vilhelmsson A, Louie SM, Wegner SA, Yuan X, Eltzschig HK, Hopf FW, Nomura DK, Koliwad SK, Xu AW

Genetic basis for the cooperative bioactivation of plant lignans by Eggerthella lenta and other human gut bacteria.

Nature microbiology

Bess EN, Bisanz JE, Yarza F, Bustion A, Rich BE, Li X, Kitamura S, Waligurski E, Ang QY, Alba DL, Spanogiannopoulos P, Nayfach S, Koliwad SK, Wolan DW, Franke AA, Turnbaugh PJ

Obesity and Fat Metabolism in Human Immunodeficiency Virus-Infected Individuals: Immunopathogenic Mechanisms and Clinical Implications.

The Journal of infectious diseases

Godfrey C, Bremer A, Alba D, Apovian C, Koethe JR, Koliwad S, Lewis D, Lo J, McComsey GA, Eckard A, Srinivasa S, Trevillyan J, Palmer C, Grinspoon S

mTORC1 to AMPK switching underlies β-cell metabolic plasticity during maturation and diabetes.

The Journal of clinical investigation

Jaafar R, Tran S, Shah AN, Sun G, Valdearcos M, Marchetti P, Masini M, Swisa A, Giacometti S, Bernal-Mizrachi E, Matveyenko A, Hebrok M, Dor Y, Rutter GA, Koliwad SK, Bhushan A

Sweet cognition: The differential effects of glucose consumption on attentional food bias in individuals of lean and obese status.

Physiology & behavior

Mason AE, Jhaveri K, Schleicher S, Almeida C, Hartman A, Wackerly A, Alba D, Koliwad SK, Epel ES, Aschbacher K

Hypothalamic microglia as potential regulators of metabolic physiology.

Nature metabolism

Valdearcos M, Myers MG, Koliwad SK

Fighting obesity by targeting factors regulating beige adipocytes.

Current opinion in clinical nutrition and metabolic care

McQueen AE, Koliwad SK, Wang JC

Subcutaneous Fat Fibrosis Links Obesity to Insulin Resistance in Chinese Americans.

The Journal of clinical endocrinology and metabolism

Alba DL, Farooq JA, Lin MYC, Schafer AL, Shepherd J, Koliwad SK

Progranulin in the hematopoietic compartment protects mice from atherosclerosis.


Nguyen AD, Nguyen TA, Singh RK, Eberlé D, Zhang J, Abate JP, Robles A, Koliwad S, Huang EJ, Maxfield FR, Walther TC, Farese RV

Microglial Inflammatory Signaling Orchestrates the Hypothalamic Immune Response to Dietary Excess and Mediates Obesity Susceptibility.

Cell metabolism

Valdearcos M, Douglass JD, Robblee MM, Dorfman MD, Stifler DR, Bennett ML, Gerritse I, Fasnacht R, Barres BA, Thaler JP, Koliwad SK

Regulation of Hepatic Lipid Accumulation and Distribution by Agouti-Related Protein in Male Mice.


Maier MT, Vilhelmsson A, Louie SM, Vagena E, Nomura DK, Koliwad SK, Xu AW

Microglia Activation Regulates Systemic Glucose Tolerance.



Interleukin-6 is both necessary and sufficient to produce perioperative neurocognitive disorder in mice.

British journal of anaesthesia

Hu J, Feng X, Valdearcos M, Lutrin D, Uchida Y, Koliwad SK, Maze M

Repression of Adipose Tissue Fibrosis through a PRDM16-GTF2IRD1 Complex Improves Systemic Glucose Homeostasis.

Cell metabolism

Hasegawa Y, Ikeda K, Chen Y, Alba DL, Stifler D, Shinoda K, Hosono T, Maretich P, Yang Y, Ishigaki Y, Chi J, Cohen P, Koliwad SK, Kajimura S

Angiopoietin-like 4 (Angptl4) protein is a physiological mediator of intracellular lipolysis in murine adipocytes.

The Journal of biological chemistry

Gray NE, Lam LN, Yang K, Zhou AY, Koliwad S, Wang JC

The C-terminal fibrinogen-like domain of angiopoietin-like 4 stimulates adipose tissue lipolysis and promotes energy expenditure.

The Journal of biological chemistry

McQueen AE, Kanamaluru D, Yan K, Gray NE, Wu L, Li ML, Chang A, Hasan A, Stifler D, Koliwad SK, Wang JC

Digital Diabetes Congress 2017.

Journal of diabetes science and technology

Klonoff DC, Kerr D, Wong JC, Pavlovic Y, Koliwad S, Hu J, Salber P, Aguilera A, Long W, Hamilton G, Chen KY, Adi S

Triglyceride Synthesis by DGAT1 Protects Adipocytes from Lipid-Induced ER Stress during Lipolysis.

Cell metabolism

Chitraju C, Mejhert N, Haas JT, Diaz-Ramirez LG, Grueter CA, Imbriglio JE, Pinto S, Koliwad SK, Walther TC, Farese RV

Microglial Inflammatory Signaling Orchestrates the Hypothalamic Immune Response to Dietary Excess and Mediates Obesity Susceptibility.

Cell metabolism

Valdearcos M, Douglass JD, Robblee MM, Dorfman MD, Stifler DR, Bennett ML, Gerritse I, Fasnacht R, Barres BA, Thaler JP, Koliwad SK

Acute Lesioning and Rapid Repair of Hypothalamic Neurons outside the Blood-Brain Barrier.

Cell reports

Yulyaningsih E, Rudenko IA, Valdearcos M, Dahlén E, Vagena E, Chan A, Alvarez-Buylla A, Vaisse C, Koliwad SK, Xu AW

Microglia mediate postoperative hippocampal inflammation and cognitive decline in mice.

JCI insight

Feng X, Valdearcos M, Uchida Y, Lutrin D, Maze M, Koliwad SK

GLUT3 upregulation promotes metabolic reprogramming associated with antiangiogenic therapy resistance.

JCI insight

Kuang R, Jahangiri A, Mascharak S, Nguyen A, Chandra A, Flanigan PM, Yagnik G, Wagner JR, De Lay M, Carrera D, Castro BA, Hayes J, Sidorov M, Garcia JLI, Eriksson P, Ronen S, Phillips J, Molinaro A, Koliwad S, Aghi MK

The Electronic CardioMetabolic Program (eCMP) for Patients With Cardiometabolic Risk: A Randomized Controlled Trial.

Journal of medical Internet research

Azar KM, Koliwad S, Poon T, Xiao L, Lv N, Griggs R, Ma J

Saturated Fatty Acids Engage an IRE1α-Dependent Pathway to Activate the NLRP3 Inflammasome in Myeloid Cells.

Cell reports

Robblee MM, Kim CC, Porter Abate J, Valdearcos M, Sandlund KL, Shenoy MK, Volmer R, Iwawaki T, Koliwad SK

Leptin potentiates astrogenesis in the developing hypothalamus.

Molecular metabolism

Rottkamp DM, Rudenko IA, Maier MT, Roshanbin S, Yulyaningsih E, Perez L, Valdearcos M, Chua S, Koliwad SK, Xu AW

Hypothalamic inflammation in the control of metabolic function.

Annual review of physiology

Valdearcos M, Xu AW, Koliwad SK

Microglia dictate the impact of saturated fat consumption on hypothalamic inflammation and neuronal function.

Cell reports

Valdearcos M, Robblee MM, Benjamin DI, Nomura DK, Xu AW, Koliwad SK

A screen in mice uncovers repression of lipoprotein lipase by microRNA-29a as a mechanism for lipid distribution away from the liver.

Hepatology (Baltimore, Md.)

Mattis AN, Song G, Hitchner K, Kim RY, Lee AY, Sharma AD, Malato Y, McManus MT, Esau CC, Koller E, Koliwad S, Lim LP, Maher JJ, Raffai RL, Willenbring H

Coordinated regulation of hepatic energy stores by leptin and hypothalamic agouti-related protein.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Warne JP, Varonin JM, Nielsen SS, Olofsson LE, Kaelin CB, Chua S, Barsh GS, Koliwad SK, Xu AW

Angiopoietin-like 4 (ANGPTL4, fasting-induced adipose factor) is a direct glucocorticoid receptor target and participates in glucocorticoid-regulated triglyceride metabolism.

Journal of Biological Chemistry

Suneil K. Koliwad, Taiyi Kuo, Lauren E. Shipp, Nora E. Gray, Fredrik Backhed, Alex Yick-Lun So, Robert V. Farese, Jen-Chywan Wang

Angiopoietin-like 4 (Angptl4) protein is a physiological mediator of intracellular lipolysis in murine adipocytes.

The Journal of biological chemistry

Gray NE, Lam LN, Yang K, Zhou AY, Koliwad S, Wang JC

Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice.


Streeper RS, Grueter CA, Salomonis N, Cases S, Levin MC, Koliwad SK, Zhou P, Hirschey MD, Verdin E, Farese RV

DGAT1-dependent triacylglycerol storage by macrophages protects mice from diet-induced insulin resistance and inflammation.

Journal of Clinical Investigation

Suneil K. Koliwad, Ryan S. Streeper, Mara Monetti, Ivo Cornelissen, Liana Chan, Koji Terayama, Stephen Naylor, Meghana Rao, Brian Hubbard, Robert V. Farese

DGAT1-dependent triacylglycerol storage by macrophages protects mice from diet-induced insulin resistance and inflammation.

The Journal of clinical investigation

Koliwad SK, Streeper RS, Monetti M, Cornelissen I, Chan L, Terayama K, Naylor S, Rao M, Hubbard B, Farese RV

Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis.

Journal of lipid research

Yen CL, Stone SJ, Koliwad S, Harris C, Farese RV

Effects of DGAT1 deficiency on energy and glucose metabolism are independent of adiponectin.

American journal of physiology. Endocrinology and metabolism

Streeper RS, Koliwad SK, Villanueva CJ, Farese RV

Increased longevity in mice lacking DGAT1.

The FASEB Journal

Ryan S Streeper, Sylvaine Cases, Suneil K Koliwad, Robert V Farese

4 Redox Regulation of Ion Channels.

Antioxidant and Redox Regulation of Genes

Suneil K. Koliwad, Anna K. Brezinska, Stephen J. Elliott

Redox control of ion channel activity in vascular endothelial cells by glutathione.

Microcirculation (New York, N.Y. : 1994)

Elliott SJ, Koliwad SK

Oxidant stress and endothelial membrane transport.

Free radical biology & medicine

Elliott SJ, Koliwad SK

Research Area: 
Adipocyte and Metabolism
Clinical Research