Shylaja Srinivasan, MD, MAS

Asst Prof of Clin Pediatrics
Pediatrics
[email protected]
+1 415 353-9084

I am a clinican-scientist and Assistant Professor of Pediatrics in the Division of Pediatric Endocrinology at UCSF. My clinical and scientific focus is on prediabetes and type 2 diabetes in youth. Specifically, I use pharmacologic and genetic approaches to evaluate pathophysiology and therapeutic strategies for youth with prediabetes and type 2 diabetes. I lead the type 2 diabetes program at the UCSF Madison Clinic for Pediatric Diabetes. I am also an Associate Program Director for the fellowship training program.

Publications: 

Cohort prevalence of young-onset type 2 diabetes in South Asia: A systematic review.

Diabetes research and clinical practice

Reji S, Sankaraeswaran M, Ulagamathesan V, Wesley H, Ramesh G, Srinivasan S, Misra S, Mohan Anjana R, Unnikrishnan R, Mohan V, Amutha A

MODY Calculator and Clinical Features Routinely Used to Distinguish MODY From Type 2 Diabetes in Adults Perform Poorly for Youth Clinically Diagnosed With Type 2 Diabetes.

Diabetes care

Kreienkamp RJ, Shields BM, Pollin TI, Shah AS, Liese AD, Bellatorre A, Pihoker C, Tosur M, Florez JC, Srinivasan S, Hattersley AT, Udler MS, Redondo MJ

Type 2 Diabetes Mellitus in Youth.

Pediatric Endocrinology

Shylaja Srinivasan, Lynne L. Levitsky

Measuring Up: Do Pediatric Endocrinology Fellows' Career Expectations Align with Workforce Reality?

The Journal of pediatrics

Nahata L, Srinivasan S, Roche CI, Leavens KF, Kim MS, Levenson A, Topor LS, Singer K, McCormack S

Polygenic risk for obesity and body dissatisfaction: beyond BMI.

Pediatric research

Jeter KM, Srinivasan S, Tryggestad JB

Increased genetic risk for β-cell failure is associated with β-cell function decline in people with prediabetes.

Diabetes

Billings LK, Jablonski KA, Pan Q, Franks PW, Goldberg RB, Hivert MF, Kahn SE, Knowler WC, Lee CG, Merino J, Huerta-Chagoya A, Mercader JM, Raghavan S, Shi Z, Srinivasan S, Xu J, Florez JC, Udler MS

1304-P: MODY Calculator Overestimates MODY Probability in Multiethnic Cohort with Youth-Onset Type 2 Diabetes Phenotype.

Diabetes

RAYMOND J. KREIENKAMP, BEVERLEY SHIELDS, TONI I. POLLIN, MUSTAFA TOSUR, AMY S. SHAH, ANGELA D. LIESE, CATHERINE PIHOKER, SHYLAJA SRINIVASAN, ANDREW T. HATTERSLEY, MIRIAM UDLER, MARIA J. REDONDO

146-OR: Clustering Pediatric Type 2 Diabetes Patients Exposes Differential Responses to Therapeutic Interventions.

Diabetes

RAYMOND J. KREIENKAMP, KIRK SMITH, THINLEY Y. WANGDEN, ELIZABETH T. JENSEN, AMY S. SHAH, CATHERINE PIHOKER, LUKASZ SZCZERBINSKI, JOSE C. FLOREZ, MIRIAM UDLER, SHYLAJA SRINIVASAN

Pubertal Timing Across Asian American, Native Hawaiian, and Pacific Islander Subgroups.

JAMA network open

Kubo A, Acker J, Aghaee S, Kushi LH, Quesenberry CP, Greenspan LC, Srinivasan S, Kanaya AM, Deardorff J

Genetic architecture and biology of youth-onset type 2 diabetes.

Nature metabolism

Kwak SH, Srinivasan S, Chen L, Todd J, Mercader JM, Jensen ET, Divers J, Mottl AK, Pihoker C, Gandica RG, Laffel LM, Isganaitis E, Haymond MW, Levitsky LL, Pollin TI, Florez JC, Flannick J, Progress in Diabetes Genetics in Youth (ProDiGY) consortium

Re-analysis and meta-analysis of summary statistics from gene-environment interaction studies.

Bioinformatics (Oxford, England)

Pham DT, Westerman KE, Pan C, Chen L, Srinivasan S, Isganaitis E, Vajravelu ME, Bacha F, Chernausek S, Gubitosi-Klug R, Divers J, Pihoker C, Marcovina SM, Manning AK, Chen H

A Type 1 Diabetes Polygenic Score Is Not Associated With Prevalent Type 2 Diabetes in Large Population Studies.

Journal of the Endocrine Society

Srinivasan S, Wu P, Mercader JM, Udler MS, Porneala BC, Bartz TM, Floyd JS, Sitlani C, Guo X, Haessler J, Kooperberg C, Liu J, Ahmad S, van Duijn C, Liu CT, Goodarzi MO, Florez JC, Meigs JB, Rotter JI, Rich SS, Dupuis J, Leong A

Current insights and emerging trends in early-onset type 2 diabetes.

The lancet. Diabetes & endocrinology

Misra S, Ke C, Srinivasan S, Goyal A, Nyriyenda MJ, Florez JC, Khunti K, Magliano DJ, Luk A

Identification of Genetic Variation Influencing Metformin Response in a Multi-Ancestry Genome-Wide Association Study in the Diabetes Prevention Program (DPP).

Diabetes

Li JH, Perry JA, Jablonski KA, Srinivasan S, Chen L, Todd JN, Harden M, Mercader JM, Pan Q, Dawed AY, Yee SW, Pearson ER, Giacomini KM, Giri A, Hung AM, Xiao S, Williams LK, Franks PW, Hanson RL, Kahn SE, Knowler WC, Pollin TI, Florez JC, Diabetes Prevention Program Research Group

Greater Improvement in Obesity Among Children With Prediabetes in a Clinical Weight Management Program.

Childhood obesity (Print)

Tester JM, Xiao L, Chau CA, Tinajero-Deck L, Srinivasan S, Rosas LG

1091-P: Genetic Ancestry Influences Metformin Treatment Response in Youth with Type 2 Diabetes.

Diabetes

SHYLAJA SRINIVASAN, LING CHEN, MEGAN M. KELSEY, JENNIFER TODD, SILVA A. ARSLANIAN, NANCY T. CHANG, LORI M. LAFFEL, LYNNE L. LEVITSKY, JENNIFER E. SPRAGUE, TONI I. POLLIN, ALISA MANNING, JOSE C. FLOREZ

Initial Insights into the Genetic Variation Associated with Metformin Treatment Failure in Youth with Type 2 Diabetes.

Pediatric diabetes

Srinivasan S, Chen L, Udler M, Todd J, Kelsey MM, Haymond MW, Arslanian S, Zeitler P, Gubitosi-Klug R, Nadeau KJ, Kutney K, White NH, Li JH, Perry JA, Kaur V, Brenner L, Mercader JM, Dawed A, Pearson ER, Yee SW, Giacomini KM, Pollin T, Florez JC

Insights from rare variants into the genetic architecture and biology of youth-onset type 2 diabetes.

Research square

Kwak SH, Srinivasan S, Chen L, Todd J, Mercader J, Jensen E, Divers J, Mottl A, Pihoker C, Gandica R, Laffel L, Isganaitis E, Haymond M, Levitsky L, Pollin T, Florez J, Flannick J

The power of TOPMed imputation for the discovery of Latino-enriched rare variants associated with type 2 diabetes.

Diabetologia

Huerta-Chagoya A, Schroeder P, Mandla R, Deutsch AJ, Zhu W, Petty L, Yi X, Cole JB, Udler MS, Dornbos P, Porneala B, DiCorpo D, Liu CT, Li JH, Szczerbinski L, Kaur V, Kim J, Lu Y, Martin A, Eizirik DL, Marchetti P, Marselli L, Chen L, Srinivasan S, Todd J, Flannick J, Gubitosi-Klug R, Levitsky L, Shah R, Kelsey M, Burke B, Dabelea DM, Divers J, Marcovina S, Stalbow L, Loos RJF, Darst BF, Kooperberg C, Raffield LM, Haiman C, Sun Q, McCormick JB, Fisher-Hoch SP, Ordoñez ML, Meigs J, Baier LJ, González-Villalpando C, González-Villalpando ME, Orozco L, García-García L, Moreno-Estrada A, Mexican Biobank, Aguilar-Salinas CA, Tusié T, Dupuis J, Ng MCY, Manning A, Highland HM, Cnop M, Hanson R, Below J, Florez JC, Leong A, Mercader JM

Pancreatic autoantibodies in individuals with a clinical diagnosis of type 2 diabetes mellitus.

Journal of Pediatric Endocrinology and Diabetes

Jeffrey Ernest Ferrell, Michael A. Kohn, Shylaja Srinivasan

Real-Time Continuous Glucose Monitoring in Adolescents and Young Adults With Type 2 Diabetes Can Improve Quality of Life.

Journal of diabetes science and technology

Chesser H, Srinivasan S, Puckett C, Gitelman SE, Wong JC

The COVID-19 pandemic is associated with a substantial rise in frequency and severity of presentation of youth-onset type 2 diabetes.

The Journal of pediatrics

Magge SN, Wolf RM, Pyle L, Brown EA, Benavides VC, Bianco ME, Chao LC, Cymbaluk A, Gumus Balikcioglu P, Halpin K, Hsia DS, Huerta-Saenz L, Kim JJ, Kumar S, Levitt Katz LE, Marks BE, Neyman A, O'Sullivan KL, Sasidharan Pillai S, Shah AS, Shoemaker AH, Siddiqui JAW, Srinivasan S, Thomas IH, Tryggestad JB, Yousif MF, Kelsey MM, COVID-19 and Type 2 Diabetes Consortium

Rickets in a child with prolonged acquired hypothyroidism secondary to Hashimoto's thyroiditis.

Endocrinology, diabetes & metabolism case reports

Schulmeister C, Lee J, Perwad F, Long R, Srinivasan S

Genome-wide Association Study of Lipid Traits in Youth With Type 2 Diabetes.

Journal of the Endocrine Society

Santoro N, Chen L, Todd J, Divers J, Shah AS, Gidding SS, Burke B, Haymond M, Lange L, Marcovina S, Flannick J, Caprio S, Florez JC, Srinivasan S

Monogenic Diabetes in Youth With Presumed Type 2 Diabetes: Results From the Progress in Diabetes Genetics in Youth (ProDiGY) Collaboration.

Diabetes care

Todd JN, Kleinberger JW, Zhang H, Srinivasan S, Tollefsen SE, Levitsky LL, Levitt Katz LE, Tryggestad JB, Bacha F, Imperatore G, Lawrence JM, Pihoker C, Divers J, Flannick J, Dabelea D, Florez JC, Pollin TI

Adjunctive Therapies to Optimize Closed-loop Glucose Control.

Journal of diabetes science and technology

Srinivasan S, Ekhlaspour L, Cengiz E

23-OR: ADA Presidents’ Select Abstract: Genetic Architecture and Novel Genes Implicated in Youth-Onset Type 2 Diabetes.

Diabetes

SOO HEON KWAK, SHYLAJA SRINIVASAN, LING CHEN, JENNIFER TODD, ELIZABETH T. JENSEN, JASMIN DIVERS, AMY K. MOTTL, CATHERINE PIHOKER, RACHELLE GANDICA, LORI M. LAFFEL, ELVIRA M. ISGANAITIS, MOREY W. HAYMOND, LYNNE L. LEVITSKY, TONI I. POLLIN, JOSE C. FLOREZ, JASON FLANNICK

249-OR: Type 2 Diabetes (T2D) Genetic Clusters for Association with Glycemic Responses to Intervention for Diabetes Prevention.

Diabetes

LIANA K. BILLINGS, KATHLEEN A. JABLONSKI, PAUL W. FRANKS, RONALD B. GOLDBERG, MARIE-FRANCE HIVERT, STEVEN E. KAHN, WILLIAM C. KNOWLER, CHRISTINE LEE, JORDI MERINO, SRIDHARAN RAGHAVAN, SHYLAJA SRINIVASAN, JIANFENG XU, JOSE C. FLOREZ, MIRIAM UDLER

28-OR: Identification of Ancestry-Specific Alleles in a Genome-Wide Association Study (GWAS) for Metformin (MET) Response in the Diabetes Prevention Program (DPP).

Diabetes

JOSEPHINE H. LI, JAMES A. PERRY, KATHLEEN A. JABLONSKI, LING CHEN, SHYLAJA SRINIVASAN, JENNIFER N. TODD, MAEGAN HARDEN, JOSEP M. MERCADER, PAUL W. FRANKS, ROBERT L. HANSON, STEVEN E. KAHN, WILLIAM C. KNOWLER, TONI I. POLLIN, JOSE C. FLOREZ, DPP RESEARCH GROUP

The First Genome-Wide Association Study for Type 2 Diabetes in Youth: The Progress in Diabetes Genetics in Youth (ProDiGY) Consortium.

Diabetes

Srinivasan S, Chen L, Todd J, Divers J, Gidding S, Chernausek S, Gubitosi-Klug RA, Kelsey MM, Shah R, Black MH, Wagenknecht LE, Manning A, Flannick J, Imperatore G, Mercader JM, Dabelea D, Florez JC, ProDiGY Consortium

A Polygenic Lipodystrophy Genetic Risk Score Characterizes Risk Independent of BMI in the Diabetes Prevention Program.

Journal of the Endocrine Society

Srinivasan S, Jablonski KA, Knowler WC, Dagogo-Jack S, E Kahn S, Boyko EJ, Bray GA, Horton ES, Hivert MF, Goldberg R, Chen L, Mercader J, Harden M, Florez JC, Diabetes Prevention Program Research Group

177-OR: Genome-Wide Association Study of Lipid Traits in Youth with Type 2 Diabetes: The ProDiGY (Progress in Diabetes Genetics in Youth) Consortium.

Diabetes

LING CHEN, SHYLAJA SRINIVASAN, NICOLA SANTORO, JENNIFER TODD, JASMIN DIVERS, AMY SANGHAVI SHAH, SAMUEL GIDDING, BRIAN K. BURKE, MOREY W. HAYMOND, LESLIE LANGE, SANTICA M. MARCOVINA, ALAN CHAIT, JASON FLANNICK, SONIA CAPRIO, JOSE C. FLOREZ

MON-268 A Rare Case of Primary Hypoaldosteronism in a Newborn.

Journal of the Endocrine Society

Armaiti Mody, Janet Lee, Jessica Tenney, Shylaja Srinivasan

A Comprehensive Type 1 Diabetes Genetic Risk Score Is Associated with Type 2 Diabetes in the Framingham Heart Study.

Diabetes

SHYLAJA SRINIVASAN, AARON LEONG, MIRIAM UDLER, BIANCA C. PORNEALA, JAMES B. MEIGS, STEPHEN S. RICH, JOSEE DUPUIS

Advances in the Genetics of Youth-Onset Type 2 Diabetes.

Current diabetes reports

Todd JN, Srinivasan S, Pollin TI

Pharmacogenetics of Antidiabetic Drugs.

Advances in pharmacology (San Diego, Calif.)

Srinivasan S, Yee SW, Giacomini KM

Monogenic Diabetes in the Progress for Diabetes Genetics in Youth (ProDiGY) Collaboration.

Diabetes

JENNIFER TODD, JEFFREY W. KLEINBERGER, SHYLAJA SRINIVASAN, SHERIDA E. TOLLEFSEN, LYNNE L. LEVITSKY, LORRAINE E.L. KATZ, JEANIE B. TRYGGESTAD, FIDA BACHA, GIUSEPPINA IMPERATORE, JEAN M. LAWRENCE, CATHERINE PIHOKER, JASMIN DIVERS, JASON FLANNICK, DANA DABELEA, JOSE C. FLOREZ, TONI I. POLLIN

The First Genome-Wide Association Study (GWAS) for Type 2 Diabetes in Youth from the Progress in Diabetes Genetics in Youth (ProDiGY) Collaboration.

Diabetes

SHYLAJA SRINIVASAN, JENNIFER TODD, LING CHEN, JASMIN DIVERS, SAM GIDDING, STEVEN CHERNAUSEK, ROSE GUBITOSI-KLUG, MEGAN M. KELSEY, RACHANA SHAH, MARY HELEN BLACK, LYNNE E. WAGENKNECHT, JOSE M. MERCADER, ALISA MANNING, JASON FLANNICK, DANA DABELEA, JOSE C. FLOREZ

In Advances in Pharmacology, Elsevier

The Pharmacogenetics of Anti-Diabetic Drugs

Srinivasan S., Yee SW., Giacomini K

Type 2 Diabetes Mellitus in Youth.

Pediatric Endocrinology

Shylaja Srinivasan, Lynne L. Levitsky

Therapeutic Challenges in Diabetes Prevention: We Have Not Found the "Exercise Pill".

Clinical pharmacology and therapeutics

Srinivasan S, Florez JC

Hyperthyroidism in Children.

Pediatrics in review

Shylaja Srinivasan, Madhusmita Misra

Hyperthyroidism in children.

Pediatrics in review

Srinivasan S, Misra M

Comparison of bone age readings by pediatric endocrinologists and pediatric radiologists using two bone age atlases.

Pediatric radiology

Kaplowitz P, Srinivasan S, He J, McCarter R, Hayeri MR, Sze R

Research Area: 
Sexuality research & social policy : journal of NSRC : SR & SP