Phillip Dumesic, MD, PhD

Assistant Prof in Residence

Diabetes Center

+1 415 514-0594

Energy metabolism comprises decisions by which cells shepherd the energy contained in chemical bonds. Cells transform, store, allocate, and deploy this energy in coordinated ways to influence nearly all mammalian physiology—from body heat produced by thermogenic fat to physical force generated by working muscle. We study how genetic programs instruct cellular decisions in energy metabolism, how organisms coordinate such decisions to balance systemic energy intake with expenditure, and how new therapies might modulate these processes to treat diseases such as obesity, diabetes, sarcopenia, and cachexia. Our syncretic approach unites genetics, biochemistry, and mouse physiology while leveraging individual curiosity and diverse ways of thought.

Publications:

RBM43 controls PGC1a translation and a PGC1a-STING signaling axis

In review

Dumesic PA, Wilensky SE, Bose S, Van Vranken JG, Gygi SP, Spiegelman BM

p38α kinase governs muscle strength through PGC1α in mice.

Acta physiologica (Oxford, England)

Herrera-Melle L, Cicuéndez B, López JA, Dumesic PA, Wilensky SE, Rodríguez E, Leiva-Vega L, Caballero A, León M, Vázquez J, Spiegelman BM, Folgueira C, Mora A, Sabio G

Remodeling p38 signaling in muscle controls locomotor activity via IL-15.

Science advances

Folgueira C, Herrera-Melle L, López JA, Galvan-Alvarez V, Martin-Rincon M, Cuartero MI, García-Culebras A, Dumesic PA, Rodríguez E, Leiva-Vega L, León M, Porteiro B, Iglesias C, Torres JL, Hernández-Cosido L, Bonacasa C, Marcos M, Moro MÁ, Vázquez J, Calbet JAL, Spiegelman BM, Mora A, Sabio G

Development of a functional beige fat cell line uncovers independent subclasses of cells expressing UCP1 and the futile creatine cycle.

Cell metabolism

Vargas-Castillo A, Sun Y, Smythers AL, Grauvogel L, Dumesic PA, Emont MP, Tsai LT, Rosen ED, Zammit NW, Shaffer SM, Ordonez M, Chouchani ET, Gygi SP, Wang T, Sharma AK, Balaz M, Wolfrum C, Spiegelman BM

REPTOR and CREBRF encode key regulators of muscle energy metabolism.

Nature communications

Saavedra P, Dumesic PA, Hu Y, Filine E, Jouandin P, Binari R, Wilensky SE, Rodiger J, Wang H, Chen W, Liu Y, Spiegelman BM, Perrimon N

Isolation of extracellular fluids reveals novel secreted bioactive proteins from muscle and fat tissues.

Cell metabolism

Mittenbühler MJ, Jedrychowski MP, Van Vranken JG, Sprenger HG, Wilensky S, Dumesic PA, Sun Y, Tartaglia A, Bogoslavski D, A M, Xiao H, Blackmore KA, Reddy A, Gygi SP, Chouchani ET, Spiegelman BM

RBM43 links adipose inflammation and energy expenditure through translational regulation of PGC1a.

bioRxiv : the preprint server for biology

Dumesic PA, Wilensky SE, Bose S, Van Vranken JG, Gygi SP, Spiegelman BM

SnapShot: Regulation and biology of PGC-1a.

Cell

Jannig PR, Dumesic PA, Spiegelman BM, Ruas JL

Mitochondrial TNAP controls thermogenesis by hydrolysis of phosphocreatine.

Nature

Sun Y, Rahbani JF, Jedrychowski MP, Riley CL, Vidoni S, Bogoslavski D, Hu B, Dumesic PA, Zeng X, Wang AB, Knudsen NH, Kim CR, Marasciullo A, Millán JL, Chouchani ET, Kazak L, Spiegelman BM

Dynamic changes in chromatin accessibility, altered adipogenic gene expression, and total versus de novo fatty acid synthesis in subcutaneous adipose stem cells of normal-weight polycystic ovary syndrome (PCOS) women during adipogenesis: evidence of cellu

Clinical epigenetics

Leung KL, Sanchita S, Pham CT, Davis BA, Okhovat M, Ding X, Dumesic P, Grogan TR, Williams KJ, Morselli M, Ma F, Carbone L, Li X, Pellegrini M, Dumesic DA, Chazenbalk GD

ATP Hydrolysis by the SNF2 Domain of Dnmt5 Is Coupled to Both Specific Recognition and Modification of Hemimethylated DNA.

Molecular cell

Dumesic PA, Stoddard CI, Catania S, Narlikar GJ, Madhani HD

Evolutionary Persistence of DNA Methylation for Millions of Years after Ancient Loss of a De Novo Methyltransferase.

Cell

Catania S, Dumesic PA, Pimentel H, Nasif A, Stoddard CI, Burke JE, Diedrich JK, Cooke S, Shea T, Gienger E, Lintner R, Yates JR, Hajkova P, Narlikar GJ, Cuomo CA, Pritchard JK, Madhani HD

Evolutionary Persistence of DNA Methylation for Millions of Years after Ancient Loss of a De Novo Methyltransferase.

Cell

Catania S, Dumesic PA, Pimentel H, Nasif A, Stoddard CI, Burke JE, Diedrich JK, Cook S, Shea T, Geinger E, Lintner R, Yates JR, Hajkova P, Narlikar GJ, Cuomo CA, Pritchard JK, Madhani HD

An Evolutionarily Conserved uORF Regulates PGC1α and Oxidative Metabolism in Mice, Flies, and Bluefin Tuna.

Cell metabolism

Dumesic PA, Egan DF, Gut P, Tran MT, Parisi A, Chatterjee N, Jedrychowski M, Paschini M, Kazak L, Wilensky SE, Dou F, Bogoslavski D, Cartier JA, Perrimon N, Kajimura S, Parikh SM, Spiegelman BM

Integrated Activity and Genetic Profiling of Secreted Peptidases in Cryptococcus neoformans Reveals an Aspartyl Peptidase Required for Low pH Survival and Virulence.

PLoS pathogens

Clarke SC, Dumesic PA, Homer CM, O'Donoghue AJ, La Greca F, Pallova L, Majer P, Madhani HD, Craik CS

Noncanoncial signal recognition particle RNAs in a major eukaryotic phylum revealed by purification of SRP from the human pathogen Cryptococcus neoformans.

Nucleic acids research

Dumesic PA, Rosenblad MA, Samuelsson T, Nguyen T, Moresco JJ, Yates JR, Madhani HD

Combinatorial, site-specific requirement for heterochromatic silencing factors in the elimination of nucleosome-free regions.

Genes & development

Garcia JF, Dumesic PA, Hartley PD, El-Samad H, Madhani HD

Equivalent blastocyst rates after freezing murine embryos in Cryo Bio System high security or standard instruments-medicine-veterinarian straws.

Fertility and sterility

Walker DL, Hammitt DG, Dumesic PA, Thornhill AR

Research Area:

Metabolism

Nutrition Obesity Research Center

Phillip Dumesic, MD, PhD

RBM43 controls PGC1a translation and a PGC1a-STING signaling axis

p38α kinase governs muscle strength through PGC1α in mice.

Remodeling p38 signaling in muscle controls locomotor activity via IL-15.

Development of a functional beige fat cell line uncovers independent subclasses of cells expressing UCP1 and the futile creatine cycle.

REPTOR and CREBRF encode key regulators of muscle energy metabolism.

Isolation of extracellular fluids reveals novel secreted bioactive proteins from muscle and fat tissues.

RBM43 links adipose inflammation and energy expenditure through translational regulation of PGC1a.

SnapShot: Regulation and biology of PGC-1a.

Mitochondrial TNAP controls thermogenesis by hydrolysis of phosphocreatine.

Dynamic changes in chromatin accessibility, altered adipogenic gene expression, and total versus de novo fatty acid synthesis in subcutaneous adipose stem cells of normal-weight polycystic ovary syndrome (PCOS) women during adipogenesis: evidence of cellu

ATP Hydrolysis by the SNF2 Domain of Dnmt5 Is Coupled to Both Specific Recognition and Modification of Hemimethylated DNA.

Evolutionary Persistence of DNA Methylation for Millions of Years after Ancient Loss of a De Novo Methyltransferase.

Evolutionary Persistence of DNA Methylation for Millions of Years after Ancient Loss of a De Novo Methyltransferase.

An Evolutionarily Conserved uORF Regulates PGC1α and Oxidative Metabolism in Mice, Flies, and Bluefin Tuna.

Integrated Activity and Genetic Profiling of Secreted Peptidases in Cryptococcus neoformans Reveals an Aspartyl Peptidase Required for Low pH Survival and Virulence.

Noncanoncial signal recognition particle RNAs in a major eukaryotic phylum revealed by purification of SRP from the human pathogen Cryptococcus neoformans.

Product binding enforces the genomic specificity of a yeast polycomb repressive complex.

Recognizing the enemy within: licensing RNA-guided genome defense.

The spliceosome as a transposon sensor.

Stalled spliceosomes are a signal for RNAi-mediated genome defense.

Ers1 links HP1 to RNAi.

Combinatorial, site-specific requirement for heterochromatic silencing factors in the elimination of nucleosome-free regions.

Erk1/2 MAP kinases are required for epidermal G2/M progression.

Selective role for Mek1 but not Mek2 in the induction of epidermal neoplasia.

Mek1/2 gene dosage determines tissue response to oncogenic Ras signaling in the skin.

Mek1/2 MAPK kinases are essential for Mammalian development, homeostasis, and Raf-induced hyperplasia.

Effects of active MEK1 expression in vivo.

Mek1 alters epidermal growth and differentiation.

Equivalent blastocyst rates after freezing murine embryos in Cryo Bio System high security or standard instruments-medicine-veterinarian straws.

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Phillip Dumesic, MD, PhD

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