Martin Valdearcos Contreras, PhD

Assistant Adjunct Professor
Diabetes Center
+1 415 476-9847

My research interest focuses on the emerging field of neuro-immune interactions underlying obesity, and in particular how immunological and metabolic responses affect homeostasis and disease pathogenesis. I have a particular interest in understanding how CNS myeloid cells sense metabolic factors and interact with hypothalamic neurons to control energy and glucose homeostasis.


Microglial Inflammatory Signaling Orchestrates the Hypothalamic Immune Response to Dietary Excess and Mediates Obesity Susceptibility.

Cell metabolism

Valdearcos M, Douglass JD, Robblee MM, Dorfman MD, Stifler DR, Bennett ML, Gerritse I, Fasnacht R, Barres BA, Thaler JP, Koliwad SK

Acute Lesioning and Rapid Repair of Hypothalamic Neurons outside the Blood-Brain Barrier.

Cell reports

Yulyaningsih E, Rudenko IA, Valdearcos M, Dahlén E, Vagena E, Chan A, Alvarez-Buylla A, Vaisse C, Koliwad SK, Xu AW

Microglia mediate postoperative hippocampal inflammation and cognitive decline in mice.

JCI insight

Feng X, Valdearcos M, Uchida Y, Lutrin D, Maze M, Koliwad SK

Critical role for cytosolic group IVA phospholipase A2 in early adipocyte differentiation and obesity.

Biochimica et biophysica acta

Peña L, Meana C, Astudillo AM, Lordén G, Valdearcos M, Sato H, Murakami M, Balsinde J, Balboa MA

Saturated Fatty Acids Engage an IRE1α-Dependent Pathway to Activate the NLRP3 Inflammasome in Myeloid Cells.

Cell reports

Robblee MM, Kim CC, Porter Abate J, Valdearcos M, Sandlund KL, Shenoy MK, Volmer R, Iwawaki T, Koliwad SK

Leptin potentiates astrogenesis in the developing hypothalamus.

Molecular metabolism

Rottkamp DM, Rudenko IA, Maier MT, Roshanbin S, Yulyaningsih E, Perez L, Valdearcos M, Chua S, Koliwad SK, Xu AW

Hypothalamic inflammation in the control of metabolic function.

Annual review of physiology

Valdearcos M, Xu AW, Koliwad SK

Microglia dictate the impact of saturated fat consumption on hypothalamic inflammation and neuronal function.

Cell reports

Valdearcos M, Robblee MM, Benjamin DI, Nomura DK, Xu AW, Koliwad SK

Lipin-1 integrates lipid synthesis with proinflammatory responses during TLR activation in macrophages.

Journal of immunology (Baltimore, Md. : 1950)

Meana C, Peña L, Lordén G, Esquinas E, Guijas C, Valdearcos M, Balsinde J, Balboa MA

Lipin-2 reduces proinflammatory signaling induced by saturated fatty acids in macrophages.

The Journal of biological chemistry

Valdearcos M, Esquinas E, Meana C, Peña L, Gil-de-Gómez L, Balsinde J, Balboa MA

Subcellular localization and role of lipin-1 in human macrophages.

Journal of immunology (Baltimore, Md. : 1950)

Valdearcos M, Esquinas E, Meana C, Gil-de-Gómez L, Guijas C, Balsinde J, Balboa MA

Requirement of JNK-mediated phosphorylation for translocation of group IVA phospholipase A2 to phagosomes in human macrophages.

Journal of immunology (Baltimore, Md. : 1950)

Casas J, Meana C, Esquinas E, Valdearcos M, Pindado J, Balsinde J, Balboa MA

Research Area: 
Central Regulation