Markus Delling, PhD

Asst Professor
+1 415 476-2308

Testing the ion-current model for flagellar length sensing and IFT regulation.


Ishikawa H, Moore J, Diener DR, Delling M, Marshall WF

Conversion of anterograde into retrograde trains is an intrinsic property of intraflagellar transport.

Current biology : CB

Nievergelt AP, Zykov I, Diener D, Chhatre A, Buchholz TO, Delling M, Diez S, Jug F, ?tep?nek L, Pigino G


British journal of pharmacology

Alexander SP, Mathie A, Peters JA, Veale EL, Striessnig J, Kelly E, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Southan C, Davies JA, Aldrich RW, Attali B, Baggetta AM, Becirovic E, Biel M, Bill RM, Catterall WA, Conner AC, Davies P, Delling M, Virgilio FD, Falzoni S, Fenske S, George C, Goldstein SAN, Grissmer S, Ha K, Hammelmann V, Hanukoglu I, Jarvis M, Jensen AA, Kaczmarek LK, Kellenberger S, Kennedy C, King B, Kitchen P, Lynch JW, Perez-Reyes E, Plant LD, Rash L, Ren D, Salman MM, Sivilotti LG, Smart TG, Snutch TP, Tian J, Trimmer JS, Van den Eynde C, Vriens J, Wei AD, Winn BT, Wulff H, Xu H, Yue L, Zhang X, Zhu M

The heteromeric PC-1/PC-2 polycystin complex is activated by the PC-1 N-terminus.


Ha K, Nobuhara M, Wang Q, Walker RV, Qian F, Schartner C, Cao E, Delling M

Cellular aspect ratio and cell division mechanics underlie the patterning of cell progeny in diverse mammalian epithelia.


McKinley KL, Stuurman N, Royer LA, Schartner C, Castillo-Azofeifa D, Delling M, Klein OD, Vale RD

MCOLN1 is a ROS sensor in lysosomes that regulates autophagy.

Nature communications

Zhang X, Cheng X, Yu L, Yang J, Calvo R, Patnaik S, Hu X, Gao Q, Yang M, Lawas M, Delling M, Marugan J, Ferrer M, Xu H

Primary cilia are not calcium-responsive mechanosensors.


Delling M, Indzhykulian AA, Liu X, Li Y, Xie T, Corey DP, Clapham DE

Ion channels and calcium signaling in motile cilia.


Doerner JF, Delling M, Clapham DE

Direct Recording and Molecular Identification of the Calcium Channel of Primary Cilia.

Biophysical Journal

Paul G. DeCaen, Markus Delling, David E. Clapham

Primary cilia are specialized calcium signalling organelles.


Delling M, DeCaen PG, Doerner JF, Febvay S, Clapham DE

Molecular dynamics of ion transport through the open conformation of a bacterial voltage-gated sodium channel.

Proceedings of the National Academy of Sciences of the United States of America

Ulmschneider MB, Bagnéris C, McCusker EC, Decaen PG, Delling M, Clapham DE, Ulmschneider JP, Wallace BA

Cleavage of TRPM7 releases the kinase domain from the ion channel and regulates its participation in Fas-induced apoptosis.

Developmental cell

Desai BN, Krapivinsky G, Navarro B, Krapivinsky L, Carter BC, Febvay S, Delling M, Penumaka A, Ramsey IS, Manasian Y, Clapham DE

Transient receptor potential cation channel, subfamily C, member 5 (TRPC5) is a cold-transducer in the peripheral nervous system.

Proceedings of the National Academy of Sciences of the United States of America

Zimmermann K, Lennerz JK, Hein A, Link AS, Kaczmarek JS, Delling M, Uysal S, Pfeifer JD, Riccio A, Clapham DE

PI(3,5)P2 Controls Membrane Trafficking by Direct Activation of Mucolipin Ca2+ Release Channels in the Endolysosome.

Biophysical Journal

Xiang Wang, Xianping Dong, Dongbiao Shen, Taylor Dawson, Xinran Li, Qi Zhang, Xiping Cheng, Yanling Zhang, Lois S. Weisman, Markus Delling, Haoxing Xu

PI(3,5)P(2) controls membrane trafficking by direct activation of mucolipin Ca(2+) release channels in the endolysosome.

Nature communications

Dong XP, Shen D, Wang X, Dawson T, Li X, Zhang Q, Cheng X, Zhang Y, Weisman LS, Delling M, Xu H

Activating mutations of the TRPML1 channel revealed by proline-scanning mutagenesis.

The Journal of biological chemistry

Dong XP, Wang X, Shen D, Chen S, Liu M, Wang Y, Mills E, Cheng X, Delling M, Xu H

Activation Mutations of the TRPML1 Channel Revealed by Proline Scanning Mutagenesis.

Biophysical Journal

Xiang Wang, Xianping Dong, Su Chen, Dongbiao Shen, Meiling Liu, Eric Mills, Xiping Cheng, Markus Delling, Haoxing Xu

The Type IV Mucolipidosis-Associated Protein TRPML1 is an Endolysosomal Iron Release Channel.

Biophysical Journal

Xian-Ping Dong, Xiping Cheng, Eric Mills, Markus Delling, Fudi Wang, Tino Kurz, Haoxing Xu

The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel.


Dong XP, Cheng X, Mills E, Delling M, Wang F, Kurz T, Xu H

Fibroblast growth factor-regulated palmitoylation of the neural cell adhesion molecule determines neuronal morphogenesis.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Ponimaskin E, Dityateva G, Ruonala MO, Fukata M, Fukata Y, Kobe F, Wouters FS, Delling M, Bredt DS, Schachner M, Dityatev A

Activating mutation in a mucolipin transient receptor potential channel leads to melanocyte loss in varitint-waddler mice.

Proceedings of the National Academy of Sciences of the United States of America

Xu H, Delling M, Li L, Dong X, Clapham DE

An introduction to TRP channels.

Annual review of physiology

Ramsey IS, Delling M, Clapham DE

The Role of Lipid Rafts in Signal Transduction and Synaptic Plasticity of Neural Cells.

Membrane Microdomain Signaling

Markus Delling, Melitta Schachner

Polysialylated neural cell adhesion molecule promotes remodeling and formation of hippocampal synapses.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Dityatev A, Dityateva G, Sytnyk V, Delling M, Toni N, Nikonenko I, Muller D, Schachner M

Rapid and efficient electroporation-based gene transfer into primary dissociated neurons.

Journal of neuroscience methods

Dityateva G, Hammond M, Thiel C, Ruonala MO, Delling M, Siebenkotten G, Nix M, Dityatev A

The neural cell adhesion molecule regulates cell-surface delivery of G-protein-activated inwardly rectifying potassium channels via lipid rafts.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Delling M, Wischmeyer E, Dityatev A, Sytnyk V, Veh RW, Karschin A, Schachner M

Cosignaling of NCAM via lipid rafts and the FGF receptor is required for neuritogenesis.

The Journal of cell biology

Niethammer P, Delling M, Sytnyk V, Dityatev A, Fukami K, Schachner M

Anxiety and increased 5-HT1A receptor response in NCAM null mutant mice.

Journal of neurobiology

Stork O, Welzl H, Wotjak CT, Hoyer D, Delling M, Cremer H, Schachner M

Research Area: 
Central Regulation