Meghana Gadgil, MD, MPH

Associate Clinical Professor
Medicine
+1 415 353-7900

My long-term goal is to prevent cardiometabolic disease in high-risk populations through a three-level approach: 1) clinical investigation of metabolomic processes at the individual level 2) improvements in chronic disease prevention inside the primary care office and 3) lifestyle changes with a focus on practical dietary interventions in the lived environment.

At the individual level:
My clinical research activities center on the metabolic processes connecting dietary intake and incident diabetes which are not yet well-characterized. I believe that further work with "omics" technologies can help to delineate the paths between diet and diabetes and identify targets for intervention.

Inside the PCP's office:
I am developing a program to improve postpartum transitions to primary care for women with gestational diabetes. In this program, we are identifying women with a pregnancy affected by GDM who are at high risk of transition to type 2 diabetes. We are then designing programs within our medical record system to track, improve postpartum follow-up and enroll patients into primary care.

In the lived environment:
A current research award from the Mount Zion Health Fund is supporting work improving the knowledge and uptake of prediabetes resources in the community.

I have completed a pilot intervention study enrolling participants with prediabetes to evaluate the impact evaluation walnut intake on dietary quality, measures of prediabetes and metabolite expression.

I am committed to work in the prevention of diabetes as it disproportionally impacts racial and ethnic minority populations. I also focus on research into the specific risk factors that women face in the development of diabetes, particularly those in the postpartum period. I feel strongly that each population should have appropriate and equitable guidance for a personalized care plan for the prevention of diabetes.

My future goals are to extend and individualize current knowledge about beneficial dietary and lifestyle interventions to prevent cardiometabolic disease, and to use digital tools and metabolomics to monitor responsiveness to these programs.

Publications: 

Dietary Patterns in the Mediators of Atherosclerosis in South Asians Living in America (MASALA) Study: Comparisons Across Methodologies.

Current developments in nutrition

Jeannette M Beasley, Bridget Murphy Hussain, Meghana Gadgil, Sameera Talegawkar, Shilpa Bhupathiraju, Nadia Islam, Niyati Parekh, Alka Kanaya

Metabolite profiles of plant-based diets and cardiometabolic risk in the Mediators of Atherosclerosis in South Asians Living in America (MASALA) Study.

The Journal of nutrition

Sawicki CM, Ren Y, Kanaya AM, Kandula N, Gadgil M, Liang L, Haslam DE, Bhupathiraju SN

2080-LB: Metabolite Profiles of Liver Fat and BMI in the MultiEthnic Study of Atherosclerosis (MESA) and Mediators of Atherosclerosis in South Asians Living in America (MASALA) studies.

Diabetes

MEGHANA D. GADGIL, BENJAMIN M. STROEBEL, ALKA M. KANAYA, ALEXIS WOOD, XIUQING GUO, JEROME I. ROTTER, PHILIP GREENLAND, DAVID M. HERRINGTON

Longitudinal Associations Between MicroRNAs and Weight in the Diabetes Prevention Program.

bioRxiv : the preprint server for biology

Flowers E, Stroebel B, Gong X, Lewis K, Aouizerat BE, Gadgil M, Kanaya AM, Zhang L

Abstract P114: Micro RNAs Associated With Clinical Classifiers of Gender, Race and Ethnicity in the Diabetes Prevention Program.

Circulation

Benjamin M Stroebel, Li Zhang, Bradley E Aouizerat, Kimberly A Lewis, Kayla D Longoria, Meghana Gadgil, Elena Flowers

Adipose tissue-derived metabolite risk scores and risk for type 2 diabetes in South Asians.

International journal of obesity (2005)

Gadgil MD, Cheng J, Herrington DM, Kandula NR, Kanaya AM

Reflecting on a Year at the Helm of Diabetes Care.

Diabetes care

Kahn SE, Anderson CAM, Buse JB, Selvin E, Angell SY, Aroda VR, Cheng AYY, Danne T, Echouffo-Tcheugui JB, Fitzpatrick SL, Gadgil MD, Gastaldelli A, Gloyn AL, Green JB, Jastreboff AM, Kanaya AM, Kandula NR, Kovesdy CP, Laiteerapong N, Nadeau KJ, Pettus J, Pop-Busui R, Posey JE, Powe CE, Rebholz CM, Rickels MR, Sattar N, Shaw JE, Sims EK, Utzschneider KM, Vella A, Zhang C

Untargeted metabolomic analysis investigating links between unprocessed red meat intake and markers of inflammation.

The American journal of clinical nutrition

Wood AC, Graca G, Gadgil M, Senn MK, Allison MA, Tzoulaki I, Greenland P, Ebbels T, Elliott P, Goodarzi MO, Tracy R, Rotter JI, Herrington D

Concordance between Dash Diet and Hypertension: Results from the Mediators of Atherosclerosis in South Asians Living in America (MASALA) Study.

Nutrients

Hussain BM, Deierlein AL, Kanaya AM, Talegawkar SA, O'Connor JA, Gadgil MD, Lin Y, Parekh N

Associations between Metabolomic Biomarkers of Avocado Intake and Glycemia in the Multi-Ethnic Study of Atherosclerosis.

The Journal of nutrition

Wood AC, Goodarzi MO, Senn MK, Gadgil MD, Graca G, Allison MA, Tzoulaki I, Mi MY, Greenland P, Ebbels T, Elliott P, Tracy RP, Herrington DM, Rotter JI

Association of Physical Activity and Dietary Quality with Weight, Ectopic Fat, and Insulin Resistance in South Asian Men and Women: The MASALA Study.

Journal of Clinical Lipidology

Cynthia Azam Ponir, Parag Anilkumar Chevli, Alka Kanaya, Meghana Gadgil, Luis A Rodriguez, Bharathi Upadhya, Morgana Mongraw-Chaffin

OR02-05-23 Untargeted Metabolomic Analysis Reveals Inverse Associations Between Red Meat Intake and Two Anti-Inflammatory Amino Acids.

Current developments in nutrition

Alexis Wood, Mackenzie Senn, Meghana Gadgil, Goncalo Graca, Matthew Allison, Ioanna Tzoulaki, Philip Greenland, Timothy Ebbels, Paul Elliott, Mark Goodarzi, Russell Tracy, Jerome Rotter, David Herrington

205-LB: Using Metabolomic Biomarkers to Understand Relationships between Avocado Intake and Dysglycemia.

Diabetes

ALEXIS WOOD, MARK O. GOODARZI, MEGHANA D. GADGIL, MATTHEW ALLISON, GONÇALO GRAÇA, MICHAEL Y. MI, PHILIP GREENLAND, DAVID M. HERRINGTON, JEROME I. ROTTER

Metabolomic Profile of the Healthy Eating Index-2015 in the Multiethnic Study of Atherosclerosis.

The Journal of nutrition

Gadgil MD, Wood AC, Karaman I, Graça G, Tzoulaki I, Zhong VW, Greenland P, Kanaya AM, Herrington DM

Abstract MP12: Dash Diet and Its Components is Associated With Visceral Fat Area and Hepatic Attenuation Among South Asian Adults in the Mediators of Atherosclerosis in South Asians Living in America (MASALA) Study (2010-2013).

Circulation

Bridget M Hussain, Andrea L Deierlein, Sameera A Talegawkar, Joyce A O'Connor, Meghana Gadgil, Alka M Kanaya, Namratha Kandula, Yong Lin, Niyati Parekh

"The Times They Are A-Changin'" at Diabetes Care.

Diabetes care

Kahn SE, Anderson CAM, Buse JB, Selvin E, Angell SY, Aroda VR, Castle JR, Cheng AYY, Danne T, Echouffo-Tcheugui JB, Florez JC, Gadgil MD, Gastaldelli A, Green JB, Jastreboff AM, Kanaya AM, Kandula NR, Kovesdy CP, Laiteerapong N, Nadeau KJ, Pop-Busui R, Powe CE, Rebholz CM, Rickels MR, Sattar N, Shaw JE, Sims EK, Utzschneider KM, Vella A, Zhang C

Prepregnancy Protein Source and BCAA Intake Are Associated with Gestational Diabetes Mellitus in the CARDIA Study.

International journal of environmental research and public health

Gadgil MD, Ingram KH, Appiah D, Rudd J, Whitaker KM, Bennett WL, Shikany JM, Jacobs DR, Lewis CE, Gunderson EP

Diet Patterns Are Associated With Circulating Metabolites and Lipid Profiles of South Asians in the United States.

The Journal of nutrition

Gadgil MD, Kanaya AM, Sands C, Chekmeneva E, Lewis MR, Kandula NR, Herrington DM

Diet Patterns Are Associated with Circulating Metabolites and Lipid Profiles of South Asians in the United States.

The Journal of nutrition

Gadgil MD, Kanaya AM, Sands C, Chekmeneva E, Lewis MR, Kandula NR, Herrington DM

Associations of NAFLD with circulating ceramides and impaired glycemia.

Diabetes research and clinical practice

Gadgil MD, Sarkar M, Sands C, Lewis MR, Herrington DM, Kanaya AM

Circulating metabolites and lipids are associated with glycaemic measures in South Asians.

Diabetic medicine : a journal of the British Diabetic Association

Gadgil MD, Kanaya AM, Sands C, Lewis MR, Kandula NR, Herrington DM

Acculturation is Associated with Dietary Patterns in South Asians in America.

Journal of immigrant and minority health

Gadgil MD, Kandula NR, Kanaya AM

Social network characteristics are correlated with dietary patterns among middle aged and older South Asians living in the United States (U.S.).

BMC nutrition

Talegawkar SA, Lancki N, Jin Y, Siddique J, Gadgil M, Kanaya AM, Schneider JA, Van Horn L, De Koning L, Kandula NR

Dietary Quality and Glycemic Control Among Women with Gestational Diabetes Mellitus.

Journal of women's health (2002)

Gadgil MD, Ehrlich SF, Zhu Y, Brown SD, Hedderson MM, Crites Y, Ferrara A

Dietary Patterns among Asian Indians Living in the United States Have Distinct Metabolomic Profiles That Are Associated with Cardiometabolic Risk.

The Journal of nutrition

Bhupathiraju SN, Guasch-Ferré M, Gadgil MD, Newgard CB, Bain JR, Muehlbauer MJ, Ilkayeva OR, Scholtens DM, Hu FB, Kanaya AM, Kandula NR

Type 2 diabetes after gestational diabetes mellitus in South Asian women in the United States.

Diabetes/metabolism research and reviews

Gadgil MD, Oza-Frank R, Kandula NR, Kanaya AM

Psychosocial Factors Associated with Subclinical Atherosclerosis in South Asians: The MASALA Study.

Journal of immigrant and minority health

Shah BM, Shah S, Kandula NR, Gadgil MD, Kanaya AM

Circulating micrornas associated with glycemic impairment and progression in Asian Indians.

Biomarker research

Flowers E, Gadgil M, Aouizerat BE, Kanaya AM

Dietary intakes among South Asian adults differ by length of residence in the USA.

Public health nutrition

Talegawkar SA, Kandula NR, Gadgil MD, Desai D, Kanaya AM

Dietary patterns are associated with metabolic risk factors in South Asians living in the United States.

The Journal of nutrition

Gadgil MD, Anderson CA, Kandula NR, Kanaya AM

Abstract P030: Traditional Cultural Beliefs and Length of Residence in the United States are Associated With Dietary Intakes Among South Asians.

Circulation

Sameera A Talegawkar, Namratha R Kandula, Meghana D Gadgil, Dipika Desai, Alka M Kanaya

Abstract P300: Circulating MicroRNAs Associated with Glycemic Impairment and Progression in Asian Indians.

Circulation

Elena Flowers, Bradley E Aouizerat, Meghana Gadgil, Alka M Kanaya

Do static and dynamic insulin resistance indices perform similarly in predicting pre-diabetes and type 2 diabetes?

Diabetes research and clinical practice

Liu R, Christoffel KK, Brickman WJ, Liu X, Gadgil M, Wang G, Zimmerman D, Chen Q, Wang B, Li Z, Xing H, Xu X, Wang X

Laboratory testing for and diagnosis of nutritional deficiencies in pregnancy before and after bariatric surgery.

Journal of women's health (2002)

Gadgil MD, Chang HY, Richards TM, Gudzune KA, Huizinga MM, Clark JM, Bennett WL

Screening and diagnosis of micronutrient deficiencies before and after bariatric surgery.

Obesity surgery

Gudzune KA, Huizinga MM, Chang HY, Asamoah V, Gadgil M, Clark JM

Caring for Women with Pregnancy after Bariatric Surgery.

Bariatric Surgical Practice and Patient Care

Meghana D. Gadgil, Wendy L. Bennett

Sexual ramifications of medical illness.

Clinical obstetrics and gynecology

Perez K, Gadgil M, Dizon DS

Research Area: 
Clinical Research