Frederick Hecht, MD

Recall Faculty
M_MED-CORE-DGIM
[email protected]
Research Area
Clinical Research
+1 415 353-9743

I am trained in Internal Medicine, with additional training in clinical research methods, biostatistics, and behavioral medicine. My research focus for many years was on HIV. I developed one of the largest cohorts in the world of persons followed from primary HIV (within 6 months of infection), the Options Project, in which we have examined clinical, behavioral, cardiovascular, and immunologic research questions. In 2002, I became Director of Research at the UCSF Osher Center for Integrative Medicine. My research is driven by the belief that modern medicine has made impressive advances in treating a range of health conditions, but that further advances for many of the most important health problems of our era, including obesity, diabetes, heart disease, and mental health issues require improved development and implementation of lifestyle and other non-pharmacologic approaches. An important goal of my research program is to rigorously test whether we can improve interventions for chronic health problems such as HIV, diabetes, obesity, and stress, by incorporating mindfulness and/or yoga-based components. A current example is an NIH-funded study to test whether including training in mindful eating practices decreases eating in response to food cravings and enhances adherence to a nutritional plan in type 2 diabetes. I bring a focus on clinical research methodology to the projects I am involved with. I am particularly interested in the use of innovative research methodology to strengthen the rigor of research on nonpharmacolgic health interventions, including factorial trials and Sequential Multiple Assignment Randomized Trials (SMARTs), and assessment of teacher factors in mindfulness programs to improve intervention fidelity .

In my role as Director of the UCSF Osher Center Research Program, I have played a key leadership role in building it into an internationally recognized integrative medicine research center that is distinguished by the application of innovative and rigorous research designs to studying mindfulness-based interventions, yoga, acupuncture, interoceptive awareness, and behavioral interventions. I have served in a variety of leadership roles in HIV medicine and integrative health, including as board chair of the Academic Consortium for Integrative Medicine and Health, which gives me a broad view of the field. I have a strong commitment to mentoring. I have led UCSF’s highly successful Training Research in Integrative Medicine (TRIM) fellowship program since 2006, and have served as a primary or main co-mentor for 12 NIH K awardees. I have served as PI or co-PI/project director for 31 grants, 19 of them from NIH, including leading three Program Project grants.

Publications

Author Correction: Detection of COVID-19 using multimodal data from a wearable device: results from the first TemPredict Study.

Scientific reports

Mason AE, Hecht FM, Davis SK, Natale JL, Hartogensis W, Damaso N, Claypool KT, Dilchert S, Dasgupta S, Purawat S, Viswanath VK, Klein A, Chowdhary A, Fisher SM, Anglo C, Puldon KY, Veasna D, Prather JG, Pandya LS, Fox LM, Busch M, Giordano C, Mercado BK, Song J, Jaimes R, Baum BS, Telfer BA, Philipson CW, Collins PP, Rao AA, Wang EJ, Bandi RH, Choe BJ, Epel ES, Epstein SK, Krasnoff JB, Lee MB, Lee SW, Lopez GM, Mehta A, Melville LD, Moon TS, Mujica-Parodi LR, Noel KM, Orosco MA, Rideout JM, Robishaw JD, Rodriguez RM, Shah KH, Siegal JH, Gupta A, Altintas I, Smarr BL

Detection of COVID-19 using multimodal data from a wearable device: results from the first TemPredict Study.

Scientific reports

Mason AE, Hecht FM, Davis SK, Natale JL, Hartogensis W, Damaso N, Claypool KT, Dilchert S, Dasgupta S, Purawat S, Viswanath VK, Klein A, Chowdhary A, Fisher SM, Anglo C, Puldon KY, Veasna D, Prather JG, Pandya LS, Fox LM, Busch M, Giordano C, Mercado BK, Song J, Jaimes R, Baum BS, Telfer BA, Philipson CW, Collins PP, Rao AA, Wang EJ, Bandi RH, Choe BJ, Epel ES, Epstein SK, Krasnoff JB, Lee MB, Lee SW, Lopez GM, Mehta A, Melville LD, Moon TS, Mujica-Parodi LR, Noel KM, Orosco MA, Rideout JM, Robishaw JD, Rodriguez RM, Shah KH, Siegal JH, Gupta A, Altintas I, Smarr BL

TCF-1 regulates HIV-specific CD8+ T cell expansion capacity.

JCI insight

Rutishauser RL, Deguit CDT, Hiatt J, Blaeschke F, Roth TL, Wang L, Raymond KA, Starke CE, Mudd JC, Chen W, Smullin C, Matus-Nicodemos R, Hoh R, Krone M, Hecht FM, Pilcher CD, Martin JN, Koup RA, Douek DC, Brenchley JM, Sékaly RP, Pillai SK, Marson A, Deeks SG, McCune JM, Hunt PW

The Control of HIV After Antiretroviral Medication Pause (CHAMP) Study: Posttreatment Controllers Identified From 14 Clinical Studies.

The Journal of infectious diseases

Namazi G, Fajnzylber JM, Aga E, Bosch RJ, Acosta EP, Sharaf R, Hartogensis W, Jacobson JM, Connick E, Volberding P, Skiest D, Margolis D, Sneller MC, Little SJ, Gianella S, Smith DM, Kuritzkes DR, Gulick RM, Mellors JW, Mehraj V, Gandhi RT, Mitsuyasu R, Schooley RT, Henry K, Tebas P, Deeks SG, Chun TW, Collier AC, Routy JP, Hecht FM, Walker BD, Li JZ

Epigenetic mechanisms, T-cell activation, and CCR5 genetics interact to regulate T-cell expression of CCR5, the major HIV-1 coreceptor.

Proceedings of the National Academy of Sciences of the United States of America

Gornalusse GG, Mummidi S, Gaitan AA, Jimenez F, Ramsuran V, Picton A, Rogers K, Manoharan MS, Avadhanam N, Murthy KK, Martinez H, Molano Murillo A, Chykarenko ZA, Hutt R, Daskalakis D, Shostakovich-Koretskaya L, Abdool Karim S, Martin JN, Deeks SG, Hecht F, Sinclair E, Clark RA, Okulicz J, Valentine FT, Martinson N, Tiemessen CT, Ndung'u T, Hunt PW, He W, Ahuja SK

The calm mouse: an animal model of stress reduction.

Molecular medicine (Cambridge, Mass.)

Gurfein BT, Stamm AW, Bacchetti P, Dallman MF, Nadkarni NA, Milush JM, Touma C, Palme R, Di Borgo CP, Fromentin G, Lown-Hecht R, Konsman JP, Acree M, Premenko-Lanier M, Darcel N, Hecht FM, Nixon DF

The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.

Science (New York, N.Y.)

International HIV Controllers Study, Pereyra F, Jia X, McLaren PJ, Telenti A, de Bakker PI, Walker BD, Ripke S, Brumme CJ, Pulit SL, Carrington M, Kadie CM, Carlson JM, Heckerman D, Graham RR, Plenge RM, Deeks SG, Gianniny L, Crawford G, Sullivan J, Gonzalez E, Davies L, Camargo A, Moore JM, Beattie N, Gupta S, Crenshaw A, Burtt NP, Guiducci C, Gupta N, Gao X, Qi Y, Yuki Y, Piechocka-Trocha A, Cutrell E, Rosenberg R, Moss KL, Lemay P, O'Leary J, Schaefer T, Verma P, Toth I, Block B, Baker B, Rothchild A, Lian J, Proudfoot J, Alvino DM, Vine S, Addo MM, Allen TM, Altfeld M, Henn MR, Le Gall S, Streeck H, Haas DW, Kuritzkes DR, Robbins GK, Shafer RW, Gulick RM, Shikuma CM, Haubrich R, Riddler S, Sax PE, Daar ES, Ribaudo HJ, Agan B, Agarwal S, Ahern RL, Allen BL, Altidor S, Altschuler EL, Ambardar S, Anastos K, Anderson B, Anderson V, Andrady U, Antoniskis D, Bangsberg D, Barbaro D, Barrie W, Bartczak J, Barton S, Basden P, Basgoz N, Bazner S, Bellos NC, Benson AM, Berger J, Bernard NF, Bernard AM, Birch C, Bodner SJ, Bolan RK, Boudreaux ET, Bradley M, Braun JF, Brndjar JE, Brown SJ, Brown K, Brown ST, Burack J, Bush LM, Cafaro V, Campbell O, Campbell J, Carlson RH, Carmichael JK, Casey KK, Cavacuiti C, Celestin G, Chambers ST, Chez N, Chirch LM, Cimoch PJ, Cohen D, Cohn LE, Conway B, Cooper DA, Cornelson B, Cox DT, Cristofano MV, Cuchural G, Czartoski JL, Dahman JM, Daly JS, Davis BT, Davis K, Davod SM, DeJesus E, Dietz CA, Dunham E, Dunn ME, Ellerin TB, Eron JJ, Fangman JJ, Farel CE, Ferlazzo H, Fidler S, Fleenor-Ford A, Frankel R, Freedberg KA, French NK, Fuchs JD, Fuller JD, Gaberman J, Gallant JE, Gandhi RT, Garcia E, Garmon D, Gathe JC, Gaultier CR, Gebre W, Gilman FD, Gilson I, Goepfert PA, Gottlieb MS, Goulston C, Groger RK, Gurley TD, Haber S, Hardwicke R, Hardy WD, Harrigan PR, Hawkins TN, Heath S, Hecht FM, Henry WK, Hladek M, Hoffman RP, Horton JM, Hsu RK, Huhn GD, Hunt P, Hupert MJ, Illeman ML, Jaeger H, Jellinger RM, John M, Johnson JA, Johnson KL, Johnson H, Johnson K, Joly J, Jordan WC, Kauffman CA, Khanlou H, Killian RK, Kim AY, Kim DD, Kinder CA, Kirchner JT, Kogelman L, Kojic EM, Korthuis PT, Kurisu W, Kwon DS, LaMar M, Lampiris H, Lanzafame M, Lederman MM, Lee DM, Lee JM, Lee MJ, Lee ET, Lemoine J, Levy JA, Llibre JM, Liguori MA, Little SJ, Liu AY, Lopez AJ, Loutfy MR, Loy D, Mohammed DY, Man A, Mansour MK, Marconi VC, Markowitz M, Marques R, Martin JN, Martin HL, Mayer KH, McElrath MJ, McGhee TA, McGovern BH, McGowan K, McIntyre D, Mcleod GX, Menezes P, Mesa G, Metroka CE, Meyer-Olson D, Miller AO, Montgomery K, Mounzer KC, Nagami EH, Nagin I, Nahass RG, Nelson MO, Nielsen C, Norene DL, O'Connor DH, Ojikutu BO, Okulicz J, Oladehin OO, Oldfield EC, Olender SA, Ostrowski M, Owen WF, Pae E, Parsonnet J, Pavlatos AM, Perlmutter AM, Pierce MN, Pincus JM, Pisani L, Price LJ, Proia L, Prokesch RC, Pujet HC, Ramgopal M, Rathod A, Rausch M, Ravishankar J, Rhame FS, Richards CS, Richman DD, Rodes B, Rodriguez M, Rose RC, Rosenberg ES, Rosenthal D, Ross PE, Rubin DS, Rumbaugh E, Saenz L, Salvaggio MR, Sanchez WC, Sanjana VM, Santiago S, Schmidt W, Schuitemaker H, Sestak PM, Shalit P, Shay W, Shirvani VN, Silebi VI, Sizemore JM, Skolnik PR, Sokol-Anderson M, Sosman JM, Stabile P, Stapleton JT, Starrett S, Stein F, Stellbrink HJ, Sterman FL, Stone VE, Stone DR, Tambussi G, Taplitz RA, Tedaldi EM, Telenti A, Theisen W, Torres R, Tosiello L, Tremblay C, Tribble MA, Trinh PD, Tsao A, Ueda P, Vaccaro A, Valadas E, Vanig TJ, Vecino I, Vega VM, Veikley W, Wade BH, Walworth C, Wanidworanun C, Ward DJ, Warner DA, Weber RD, Webster D, Weis S, Wheeler DA, White DJ, Wilkins E, Winston A, Wlodaver CG, van't Wout A, Wright DP, Yang OO, Yurdin DL, Zabukovic BW, Zachary KC, Zeeman B, Zhao M