Phillip Dumesic, MD, PhD

Assistant Prof in Residence
M_Diabetes Center
Research Area

We study how genes determine cellular decisions in energy metabolism, how organisms coordinate such decisions to maintain energy balance, and how new therapies might modulate these processes to treat diseases such as obesity, diabetes, sarcopenia, and cachexia. We apply genetics, biochemistry, and physiology—all driven by individual curiosity and diverse ways of thought.

Publications

Cardiac adaptation to endurance exercise training requires suppression of GDF15 via PGC-1a.

Nature cardiovascular research

Khetarpal SA, Li H, Vitale T, Rhee J, Challa S, Castro C, Pabel S, Sun Y, Liu J, Bogoslavski D, Vargas-Castillo A, Smythers AL, Blackmore KA, Grauvogel L, Mittenbühler MJ, Khandekar MJ, Curtin C, Narvaez-Paliza JM, Wang C, Houstis NE, Sprenger HG, Jurgens SJ, Biddinger KJ, Kuznetsov A, Freeman R, Ellinor PT, Nahrendorf M, Paulo JA, Gygi SP, Dumesic PA, Asnani A, Aragam KG, Puigserver P, Roh JD, Spiegelman BM, Rosenzweig A

Remodeling p38 signaling in muscle controls locomotor activity via IL-15.

Science advances

Folgueira C, Herrera-Melle L, López JA, Galvan-Alvarez V, Martin-Rincon M, Cuartero MI, García-Culebras A, Dumesic PA, Rodríguez E, Leiva-Vega L, León M, Porteiro B, Iglesias C, Torres JL, Hernández-Cosido L, Bonacasa C, Marcos M, Moro MÁ, Vázquez J, Calbet JAL, Spiegelman BM, Mora A, Sabio G

Ers1 links HP1 to RNAi.

Proceedings of the National Academy of Sciences of the United States of America

Rougemaille M, Braun S, Coyle S, Dumesic PA, Garcia JF, Isaac RS, Libri D, Narlikar GJ, Madhani HD