Marisa Medina, PhD | Nutrition Obesity Research Center

Participant-derived cell line transcriptomic analyses and mouse studies reveal a role for ZNF335 in plasma cholesterol statin response.

Genome medicine

Theusch E, Ting FY, Qin Y, Stevens K, Naidoo D, King SM, Yang NV, Orr J, Han BY, Cyster JG, Chen YI, Rotter JI, Krauss RM, Medina MW

Participant-derived cell line transcriptomic analyses and mouse studies reveal a role for ZNF335 in plasma cholesterol statin response.

bioRxiv : the preprint server for biology

Theusch E, Ting FY, Qin Y, Stevens K, Naidoo D, King SM, Yang N, Orr J, Han BY, Cyster JG, Chen YI, Rotter JI, Krauss RM, Medina MW

Development and application of an algorithm for statin-induced myopathy based on electronic health record-derived structured elements.

medRxiv : the preprint server for health sciences

Oni-Orisan A, Lu M, Peng JA, Krauss RM, Iribarren C, Medina MW

Mechanism of the Regulation of Plasma Cholesterol Levels by PI(4,5)P2.

Advances in experimental medicine and biology

Qin Y, Medina MW

Undifferentiated Induced Pluripotent Stem Cells as a Genetic Model for Nonalcoholic Fatty Liver Disease.

Cellular and molecular gastroenterology and hepatology

Muñoz A, Theusch E, Kuang YL, Nalula G, Peaslee C, Dorlhiac G, Landry MP, Streets A, Krauss RM, Iribarren C, Mattis AN, Medina MW

Modest effect of statins on fasting glucose in a longitudinal electronic health record based cohort.

Cardiovascular diabetology

Haldar T, Oni-Orisan A, Hoffmann TJ, Schaefer C, Iribarren C, Krauss RM, Medina MW, Risch N

A gene-diet interaction controlling relative intake of dietary carbohydrates and fats.

Molecular metabolism

Nelson NG, Wu L, Maier MT, Lam D, Cheang R, Alba D, Huang A, Neumann DA, Hill T, Vagena E, Barsh GS, Medina MW, Krauss RM, Koliwad SK, Xu AW

Doxycycline Significantly Enhances Induction of Induced Pluripotent Stem Cells to Endoderm by Enhancing Survival Through Protein Kinase B Phosphorylation.

Hepatology (Baltimore, Md.)

Peaslee C, Esteva-Font C, Su T, Munoz-Howell A, Duwaerts CC, Liu Z, Rao S, Liu K, Medina M, Sneddon JB, Maher JJ, Mattis AN

Effect of SLCO1B1 T521C on Statin-Related Myotoxicity With Use of Lovastatin and Atorvastatin.

Clinical pharmacology and therapeutics

Lu B, Sun L, Seraydarian M, Hoffmann TJ, Medina MW, Risch N, Iribarren C, Krauss RM, Oni-Orisan A

A unified framework identifies new links between plasma lipids and diseases from electronic medical records across large-scale cohorts.

Nature genetics

Veturi Y, Lucas A, Bradford Y, Hui D, Dudek S, Theusch E, Verma A, Miller JE, Kullo I, Hakonarson H, Sleiman P, Schaid D, Stein CM, Edwards DRV, Feng Q, Wei WQ, Medina MW, Krauss RM, Hoffmann TJ, Risch N, Voight BF, Rader DJ, Ritchie MD

Genetic variants modulate gene expression statin response in human lymphoblastoid cell lines.

BMC genomics

Theusch E, Chen YI, Rotter JI, Krauss RM, Medina MW

Phosphatidylinositol-(4,5)-Bisphosphate Regulates Plasma Cholesterol Through LDL (Low-Density Lipoprotein) Receptor Lysosomal Degradation.

Arteriosclerosis, thrombosis, and vascular biology

Qin Y, Ting F, Kim MJ, Strelnikov J, Harmon J, Gao F, Dose A, Teng BB, Alipour MA, Yao Z, Crooke R, Krauss RM, Medina MW

The impact of adjusting for baseline in pharmacogenomic genome-wide association studies of quantitative change.

NPJ genomic medicine

Oni-Orisan A, Haldar T, Ranatunga DK, Medina MW, Schaefer C, Krauss RM, Iribarren C, Risch N, Hoffmann TJ

GeneFishing to reconstruct context specific portraits of biological processes.

Proceedings of the National Academy of Sciences of the United States of America

Liu K, Theusch E, Zhou Y, Ashuach T, Dose AC, Bickel PJ, Medina MW, Huang H

Evaluation of commonly used ectoderm markers in iPSC trilineage differentiation.

Stem cell research

Kuang YL, Munoz A, Nalula G, Santostefano KE, Sanghez V, Sanchez G, Terada N, Mattis AN, Iacovino M, Iribarren C, Krauss RM, Medina MW

Characterization of Statin Low-Density Lipoprotein Cholesterol Dose-Response Using Electronic Health Records in a Large Population-Based Cohort.

Circulation. Genomic and precision medicine

Oni-Orisan A, Hoffmann TJ, Ranatunga D, Medina MW, Jorgenson E, Schaefer C, Krauss RM, Iribarren C, Risch N

ZNF542P is a pseudogene associated with LDL response to simvastatin treatment.

Scientific reports

Kim K, Theusch E, Kuang YL, Dose A, Mitchel K, Cubitt C, Chen YI, Krauss RM, Medina MW

A large electronic-health-record-based genome-wide study of serum lipids.

Nature genetics

Hoffmann TJ, Theusch E, Haldar T, Ranatunga DK, Jorgenson E, Medina MW, Kvale MN, Kwok PY, Schaefer C, Krauss RM, Iribarren C, Risch N

Generalized correlation measure using count statistics for gene expression data with ordered samples.

Bioinformatics (Oxford, England)

Wang YXR, Liu K, Theusch E, Rotter JI, Medina MW, Waterman MS, Huang H, Stegle O

Human genetic variation in VAC14 regulates Salmonella invasion and typhoid fever through modulation of cholesterol.

Proceedings of the National Academy of Sciences of the United States of America

Alvarez MI, Glover LC, Luo P, Wang L, Theusch E, Oehlers SH, Walton EM, Tram TTB, Kuang YL, Rotter JI, McClean CM, Chinh NT, Medina MW, Tobin DM, Dunstan SJ, Ko DC

SUGP1 is a novel regulator of cholesterol metabolism.

Human molecular genetics

Kim MJ, Yu CY, Theusch E, Naidoo D, Stevens K, Kuang YL, Schuetz E, Chaudhry AS, Medina MW

RP1-13D10.2 Is a Novel Modulator of Statin-Induced Changes in Cholesterol.

Circulation. Cardiovascular genetics

Mitchel K, Theusch E, Cubitt C, Dosé AC, Stevens K, Naidoo D, Medina MW

Individual and Combined Associations of Genetic Variants in CYP3A4, CYP3A5, and SLCO1B1 With Simvastatin and Simvastatin Acid Plasma Concentrations.

Journal of cardiovascular pharmacology

Luzum JA, Theusch E, Taylor KD, Wang A, Sadee W, Binkley PF, Krauss RM, Medina MW, Kitzmiller JP

GATM polymorphism associated with the risk for statin-induced myopathy does not replicate in case-control analysis of 715 dyslipidemic individuals.

Cell metabolism

Luzum JA, Kitzmiller JP, Isackson PJ, Ma C, Medina MW, Dauki AM, Mikulik EB, Ochs-Balcom HM, Vladutiu GD

Ancestry and other genetic associations with plasma PCSK9 response to simvastatin.

Pharmacogenetics and genomics

Theusch E, Medina MW, Rotter JI, Krauss RM

CYP3A422 and CYP3A53 are associated with increased levels of plasma simvastatin concentrations in the cholesterol and pharmacogenetics study cohort.

Pharmacogenetics and genomics

Kitzmiller JP, Luzum JA, Baldassarre D, Krauss RM, Medina MW

Prediction of LDL cholesterol response to statin using transcriptomic and genetic variation.

Genome biology

Kim K, Bolotin E, Theusch E, Huang H, Medina MW, Krauss RM

Transmembrane protein 55B is a novel regulator of cellular cholesterol metabolism.

Arteriosclerosis, thrombosis, and vascular biology

Medina MW, Bauzon F, Naidoo D, Theusch E, Stevens K, Schilde J, Schubert C, Mangravite LM, Rudel LL, Temel RE, Runz H, Krauss RM

Genome-wide association and pharmacological profiling of 29 anticancer agents using lymphoblastoid cell lines.

Pharmacogenomics

Brown CC, Havener TM, Medina MW, Jack JR, Krauss RM, McLeod HL, Motsinger-Reif AA

Statin-induced changes in gene expression in EBV-transformed and native B-cells.

Human molecular genetics

Bolotin E, Armendariz A, Kim K, Heo SJ, Boffelli D, Tantisira K, Rotter JI, Krauss RM, Medina MW

HNRNPA1 regulates HMGCR alternative splicing and modulates cellular cholesterol metabolism.

Human molecular genetics

Yu CY, Theusch E, Lo K, Mangravite LM, Naidoo D, Kutilova M, Medina MW

A statin-dependent QTL for GATM expression is associated with statin-induced myopathy.

Nature

Mangravite LM, Engelhardt BE, Medina MW, Smith JD, Brown CD, Chasman DI, Mecham BH, Howie B, Shim H, Naidoo D, Feng Q, Rieder MJ, Chen YD, Rotter JI, Ridker PM, Hopewell JC, Parish S, Armitage J, Collins R, Wilke RA, Nickerson DA, Stephens M, Krauss RM

Alternative splicing in the regulation of cholesterol homeostasis.

Current opinion in lipidology

Medina MW, Krauss RM

A common polymorphism in the LDL receptor gene has multiple effects on LDL receptor function.

Human molecular genetics

Gao F, Ihn HE, Medina MW, Krauss RM

ATHENA: a tool for meta-dimensional analysis applied to genotypes and gene expression data to predict HDL cholesterol levels.

Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing

Holzinger ER, Dudek SM, Frase AT, Krauss RM, Medina MW, Ritchie MD

Multivariate methods and software for association mapping in dose-response genome-wide association studies.

BioData mining

Brown CC, Havener TM, Medina MW, Krauss RM, McLeod HL, Motsinger-Reif AA

RHOA is a modulator of the cholesterol-lowering effects of statin.

PLoS genetics

Medina MW, Theusch E, Naidoo D, Bauzon F, Stevens K, Mangravite LM, Kuang YL, Krauss RM

A genome-wide association analysis of temozolomide response using lymphoblastoid cell lines shows a clinically relevant association with MGMT.

Pharmacogenetics and genomics

Brown CC, Havener TM, Medina MW, Auman JT, Mangravite LM, Krauss RM, McLeod HL, Motsinger-Reif AA

Alternative splicing of 3-hydroxy-3-methylglutaryl coenzyme A reductase is associated with plasma low-density lipoprotein cholesterol response to simvastatin.

Circulation

Medina MW, Gao F, Ruan W, Rotter JI, Krauss RM

Variation in the 3-hydroxyl-3-methylglutaryl coenzyme a reductase gene is associated with racial differences in low-density lipoprotein cholesterol response to simvastatin treatment.

Circulation

Krauss RM, Mangravite LM, Smith JD, Medina MW, Wang D, Guo X, Rieder MJ, Simon JA, Hulley SB, Waters D, Saad M, Williams PT, Taylor KD, Yang H, Nickerson DA, Rotter JI

Publications