Allison Xu, Director
NORC members wishing to benefit from NORC support accessing these services please contact this Allison Xu: [email protected]
Services Supported by the NORC Mouse Metabolism and Imaging
Provide technical support for UCSF investigators to conduct metabolic studies using a 16-chambered Comprehensive Lab Animal Monitoring System (CLAMS), a Rodent Incubator, an EchoMRI, and Dual energy X-ray absorptiometry, which together allow measurement of food intake, water intake, motor activities, core temperature, and body composition in live mice. The use of these instruments allows longitudinal measurements of key metabolic parameters in the same cohort of animals at different ages and under different feeding conditions, and will enable the accumulation of data over several months of time. We are very excited to offer access to a last generation Seahorse Bioscience XFe24 Extracellular Flux Analyzer, a platform for metabolic assays, simultaneously measuring the two major energy producing pathways of the cell – mitochondrial respiration and glycolysis - in a 24-well microplate, in real-time.
Numerous studies have shown that the microbiome has a profound effect on metabolism. The Gnotobiotics Core provides germ-free mice, fully supported gnotobiotic experiments, and germ-free re-derivation of transgenic mouse strains.Here are some of the services offered: http://gnotobiotics.ucsf.edu/services-offered
CENTER MEMBERS ARE REMINDED TO ACKNOWLEDGE THE UCSF NORC GRANT CONTRIBUTION IN THEIR PUBLICATION (P30DK098722)